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The map label for this gene is thsA [H]

Identifier: 227827624

GI number: 227827624

Start: 1283155

End: 1284837

Strand: Direct

Name: thsA [H]

Synonym: M1425_1352

Alternate gene names: 227827624

Gene position: 1283155-1284837 (Clockwise)

Preceding gene: 227827622

Following gene: 227827626

Centisome position: 49.19

GC content: 38.98

Gene sequence:

>1683_bases
ATGGCATCTCCAGTCTTATTGCTTAAAGAGGGAACGAGTAGAACTACTGGTAGAGATGCGTTAAGGAACAATATACTTGC
TGCAAAGACGCTAGCCGAAATGTTAAGGAGTAGTTTAGGTCCCAAAGGTCTTGATAAAATGTTAATTGATAGTTTCGGTG
ACGTAACCATAACTAATGATGGTGCTACAATAGTAAAGGATATGGAGATACAGCATCCAGCAGCAAAGCTATTAGTAGAA
GCAGCTAAAGCACAAGATGCTGAAGTAGGTGATGGTACTACAAGCGCTGTAGTATTAGCTGGTGCTCTATTGGAGAAAGC
TGAAAGTTTATTGGATCAAAATATACATCCAACAATAATCATTGAGGGGTATAAGAAGGCATATACCAAGGCCTTGGAGT
TACTTCCACAGTTAGGAACTAGGATCGATATAAGGGATTTGAATTCTTCAGTTGCTAGGGATACTCTAAGAAAAATAGCA
TTTACTACACTAGCAAGTAAGTTTATTGCAGAAGGTGCTGAATTAAATAAAATAATTGACATGGTAATAGACGCAATAGT
TAATGTTGCAGAACCTCTACCTAATGGTGGTTATAATGTGAGTTTAGACTTAATAAAGATAGATAAGAAGAAAGGTGGAA
GTATAGAGGATAGCGTCTTAGTTAAAGGACTAGTATTAGATAAGGAGGTTGTGCACCCTGGAATGCCTAGAAGAGTCACT
AAAGCCAAGATAGCTGTTTTGGATGCAGCATTAGAGGTAGAAAAGCCTGAAATCTCAGCTAAGATAAGTATAACATCACC
AGAGCAAATCAAGGCTTTCTTAGATGAGGAATCCAAATATCTTAAGGACATGGTTGATAAACTAGCGTCAATAGGTGCTA
ACGTTGTAATATGCCAGAAAGGTATTGATGATATCGCACAGCACTTCTTAGCTAAGAAAGGTATATTGGCTGTAAGAAGG
GTTAAGAGGAGCGATATAGAGAAATTAGAGAAGGCATTAGGCGCGAGAATAATAAGCAGTATTAAAGACGCTACTCCCGA
TGATTTAGGATACGCTGAATTAGTTGAGGAAAGGAGAGTTGGAAATGACAAAATGGTATTTATAGAAGGTGCTAAGAACT
TGAAAGCCGTAAATATCTTGTTAAGAGGTTCAAATGATATGGCATTAGATGAGGCTGAGAGGAGTATAAATGACGCATTG
CATGCTCTGAGGAACATATTATTAGAGCCAGTAATATTGCCAGGTGGTGGTGCTATCGAGTTAGAATTAGCGATGAAATT
AAGAGAGTATGCTAGAAGTGTAGGAGGTAAGGAGCAATTAGCTATAGAAGCATTTGCAGATGCATTAGAGGAGATACCTA
TGATTTTAGCTGAAACTGCAGGGCTGGAGGCTATATCTGCACTAATGGACTTAAGAGCTAGACACGCTAAGGGATTAACC
AATACTGGTGTAGATGTAATAGGTGGGAAGATCGTAGACGATGTATATGCCTTAAACATCATTGAGCCTATAAGAGTAAA
GGCTCAAGTGTTAAAGAGCGCAACAGAGGCAGCTACAGCAATATTAAAGATTGATGACCTAATAGCTGCAGCTCCATTAA
AGAGCGAGAAGAAAGGTGGAGAAGGAAGTAAAGAAGAAAGTGGTGGAGAAGGAGGAGCTGGTACTCCATCTTTAGGAGAC
TAA

Upstream 100 bases:

>100_bases
TGGATTTTCTATTAATTTAAAAAATTGCTTCACGGTTTGCTTGAGAGAAAAATTTTTATATAAGCGATACTAATGTTCTC
ACGGAACGGTGTTGTGAGGT

Downstream 100 bases:

>100_bases
ATATTTTTTATTAACTGAAACTTTAACGTTAGACTCTTCAGTGTTTTCTGTATATCCGTTTATTTCTTCCAACATTTTAT
CTGCTACTTTTTTTATGTCT

Product: thermosome

Products: NA

Alternate protein names: Chaperonin subunit alpha; Ring complex subunit alpha; Thermophilic factor 55 alpha; TF55-alpha; Thermophilic factor 56; Thermosome subunit 1 [H]

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MASPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVE
AAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYTKALELLPQLGTRIDIRDLNSSVARDTLRKIA
FTTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDDIAQHFLAKKGILAVRR
VKRSDIEKLEKALGARIISSIKDATPDDLGYAELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDAL
HALRNILLEPVILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPMILAETAGLEAISALMDLRARHAKGLT
NTGVDVIGGKIVDDVYALNIIEPIRVKAQVLKSATEAATAILKIDDLIAAAPLKSEKKGGEGSKEESGGEGGAGTPSLGD

Sequences:

>Translated_560_residues
MASPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVE
AAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYTKALELLPQLGTRIDIRDLNSSVARDTLRKIA
FTTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDDIAQHFLAKKGILAVRR
VKRSDIEKLEKALGARIISSIKDATPDDLGYAELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDAL
HALRNILLEPVILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPMILAETAGLEAISALMDLRARHAKGLT
NTGVDVIGGKIVDDVYALNIIEPIRVKAQVLKSATEAATAILKIDDLIAAAPLKSEKKGGEGSKEESGGEGGAGTPSLGD
>Mature_559_residues
ASPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITNDGATIVKDMEIQHPAAKLLVEA
AKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTIIIEGYKKAYTKALELLPQLGTRIDIRDLNSSVARDTLRKIAF
TTLASKFIAEGAELNKIIDMVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVTK
AKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQKGIDDIAQHFLAKKGILAVRRV
KRSDIEKLEKALGARIISSIKDATPDDLGYAELVEERRVGNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALH
ALRNILLEPVILPGGGAIELELAMKLREYARSVGGKEQLAIEAFADALEEIPMILAETAGLEAISALMDLRARHAKGLTN
TGVDVIGGKIVDDVYALNIIEPIRVKAQVLKSATEAATAILKIDDLIAAAPLKSEKKGGEGSKEESGGEGGAGTPSLGD

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, stimulates protein folding and has ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI24307939, Length=531, Percent_Identity=41.4312617702448, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI63162572, Length=550, Percent_Identity=37.6363636363636, Blast_Score=381, Evalue=1e-105,
Organism=Homo sapiens, GI38455427, Length=513, Percent_Identity=42.6900584795322, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI57863257, Length=542, Percent_Identity=39.4833948339483, Blast_Score=358, Evalue=5e-99,
Organism=Homo sapiens, GI5453607, Length=531, Percent_Identity=36.9114877589454, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI58761484, Length=550, Percent_Identity=34.5454545454545, Blast_Score=322, Evalue=5e-88,
Organism=Homo sapiens, GI58331173, Length=516, Percent_Identity=36.8217054263566, Blast_Score=309, Evalue=5e-84,
Organism=Homo sapiens, GI4502643, Length=524, Percent_Identity=36.4503816793893, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI261399877, Length=488, Percent_Identity=35.8606557377049, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI5453603, Length=535, Percent_Identity=34.9532710280374, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI302058290, Length=509, Percent_Identity=34.3811394891945, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI261399875, Length=443, Percent_Identity=33.6343115124154, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI48762932, Length=531, Percent_Identity=33.8983050847458, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI302058292, Length=516, Percent_Identity=32.7519379844961, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI58331171, Length=524, Percent_Identity=32.4427480916031, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI57863259, Length=391, Percent_Identity=35.8056265984655, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI58331185, Length=315, Percent_Identity=35.2380952380952, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI7657253, Length=517, Percent_Identity=26.1121856866538, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI25914754, Length=447, Percent_Identity=24.1610738255034, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI9055272, Length=447, Percent_Identity=24.1610738255034, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1790586, Length=127, Percent_Identity=36.2204724409449, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25144674, Length=531, Percent_Identity=42.3728813559322, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17532603, Length=520, Percent_Identity=41.7307692307692, Blast_Score=370, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17532601, Length=532, Percent_Identity=39.6616541353383, Blast_Score=354, Evalue=6e-98,
Organism=Caenorhabditis elegans, GI25148561, Length=562, Percent_Identity=33.9857651245552, Blast_Score=341, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI17564182, Length=531, Percent_Identity=34.8399246704331, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI25147750, Length=536, Percent_Identity=36.9402985074627, Blast_Score=308, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI25144678, Length=526, Percent_Identity=35.171102661597, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI32566944, Length=453, Percent_Identity=34.2163355408389, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI25144680, Length=403, Percent_Identity=36.4764267990074, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI71998178, Length=559, Percent_Identity=30.4114490161002, Blast_Score=232, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI71981457, Length=328, Percent_Identity=41.4634146341463, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17555558, Length=578, Percent_Identity=24.2214532871972, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=537, Percent_Identity=36.8715083798883, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322524, Length=539, Percent_Identity=38.2189239332096, Blast_Score=351, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6320418, Length=543, Percent_Identity=37.2007366482505, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6320058, Length=513, Percent_Identity=37.6218323586745, Blast_Score=330, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6322350, Length=555, Percent_Identity=34.954954954955, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6322049, Length=517, Percent_Identity=34.0425531914894, Blast_Score=266, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6320393, Length=529, Percent_Identity=32.1361058601134, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6322452, Length=541, Percent_Identity=30.6839186691312, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17647245, Length=543, Percent_Identity=40.5156537753223, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24583944, Length=518, Percent_Identity=40.9266409266409, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652903, Length=522, Percent_Identity=40.6130268199234, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24647512, Length=547, Percent_Identity=36.9287020109689, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24647510, Length=547, Percent_Identity=36.9287020109689, Blast_Score=351, Evalue=8e-97,
Organism=Drosophila melanogaster, GI24649027, Length=565, Percent_Identity=37.8761061946903, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24649029, Length=565, Percent_Identity=37.8761061946903, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24645179, Length=542, Percent_Identity=37.4538745387454, Blast_Score=341, Evalue=8e-94,
Organism=Drosophila melanogaster, GI28571140, Length=538, Percent_Identity=35.3159851301115, Blast_Score=285, Evalue=8e-77,
Organism=Drosophila melanogaster, GI18858175, Length=538, Percent_Identity=35.3159851301115, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI18859933, Length=520, Percent_Identity=34.8076923076923, Blast_Score=275, Evalue=9e-74,
Organism=Drosophila melanogaster, GI19921848, Length=550, Percent_Identity=33.8181818181818, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI20130093, Length=332, Percent_Identity=26.5060240963855, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552711, Length=332, Percent_Identity=26.5060240963855, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 59734; Mature: 59603

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND
CCCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECC
GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTII
CCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IEGYKKAYTKALELLPQLGTRIDIRDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIID
EECHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
HHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQK
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPDDLGYAELVEERRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIE
CCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEE
LELAMKLREYARSVGGKEQLAIEAFADALEEIPMILAETAGLEAISALMDLRARHAKGLT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
NTGVDVIGGKIVDDVYALNIIEPIRVKAQVLKSATEAATAILKIDDLIAAAPLKSEKKGG
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EGSKEESGGEGGAGTPSLGD
CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASPVLLLKEGTSRTTGRDALRNNILAAKTLAEMLRSSLGPKGLDKMLIDSFGDVTITND
CCCEEEEECCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECC
GATIVKDMEIQHPAAKLLVEAAKAQDAEVGDGTTSAVVLAGALLEKAESLLDQNIHPTII
CCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
IEGYKKAYTKALELLPQLGTRIDIRDLNSSVARDTLRKIAFTTLASKFIAEGAELNKIID
EECHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
MVIDAIVNVAEPLPNGGYNVSLDLIKIDKKKGGSIEDSVLVKGLVLDKEVVHPGMPRRVT
HHHHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHH
KAKIAVLDAALEVEKPEISAKISITSPEQIKAFLDEESKYLKDMVDKLASIGANVVICQK
HHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GIDDIAQHFLAKKGILAVRRVKRSDIEKLEKALGARIISSIKDATPDDLGYAELVEERRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GNDKMVFIEGAKNLKAVNILLRGSNDMALDEAERSINDALHALRNILLEPVILPGGGAIE
CCCCEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCEEE
LELAMKLREYARSVGGKEQLAIEAFADALEEIPMILAETAGLEAISALMDLRARHAKGLT
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
NTGVDVIGGKIVDDVYALNIIEPIRVKAQVLKSATEAATAILKIDDLIAAAPLKSEKKGG
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EGSKEESGGEGGAGTPSLGD
CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7473746 [H]