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The map label for this gene is lhr [C]

Identifier: 227826660

GI number: 227826660

Start: 215595

End: 217742

Strand: Direct

Name: lhr [C]

Synonym: M1425_0251

Alternate gene names: 227826660

Gene position: 215595-217742 (Clockwise)

Preceding gene: 227826657

Following gene: 227826670

Centisome position: 8.26

GC content: 36.55

Gene sequence:

>2148_bases
ATGAGTTTAGAATTAGAGTGGATGTCAATAGACGACCTAAAATTACCTAGTAACGTTATTGATATAATAAAAAATAGGGG
TATAAAAAAACTTAACCCACCTCAAACTGAAGCGGTAAAAAAAGGTCTATTAGATGGAAATAGACTACTATTGACTTCGC
CTACTGGTTCTGGGAAGACACTAATAGCAGAGATGGGAATAATTTCATTTCTTCTAAAAAACGGAGGAAAAGCAATATAT
GTGACCCCACTTAGGGCTCTTACGAATGAAAAGTATTTAACTTTTAAGGATTGGGAATCAATAGGTTTTAAAGTGGCTAT
GACTTCAGGTGATTATGATACAGATGATGCTTGGTTGAAGAATTATGATATTATAATCACCACTTATGAAAAGTTAGATT
CCCTATGGCGTCATAGACCAGATTGGCTTAATGAGGCTAATTATTTCGTATTGGACGAACTACATTACCTTAACGATCCT
GAAAGAGGGCCAGTAGTTGAGAGCGTCACAATAAGGGCTAAAAGGAGAAATCTATTGGCATTGAGTGCTACAATAAGTAA
CTATAAGCAAATAGCTAAATGGTTAGGAGCAGAACCAGTGGCAACGAATTGGAGACCAGTTCCCCTCATGGAGGGTGTTA
TGTATCCAGAGAGAAAAAAGAAGGAATATACTATACTTTTCAGAGATAATACTACCAAGAAGGTTCATGGAGATGACGCC
ATAATAGCTTATACTCTAGATAGTCTAACCAAAAATGGACAAGTTTTAGTTTTTAGGAATTCCAGGAAAATGGCAGAAAG
TACAGCATTAAAGATTGCAAATTACATGAATTTTGTAAGTTTAGATGAGAAAGCAATATCTGAGATTTTAAATCAATTGG
ATGATATCGAGGAAGGTGGAAGTGATGAAAAAGAGTTACTAAAATCTCTTATAAGTAAGGGAGTTGCATATCATCACGCT
GGACTATCAAAGGCGTTAAGGGATATAATAGAGGAGAGTTTCCGGAAAAGAAAAATAAAGGTGATCGTAGCAACTCCAAC
CTTGGCAGCTGGCGTAAATTTACCTGCTAGAACAGTAATAATAGGAGATATTTATCGATTCAATAGGAAGATAGTTGGAT
ATTACGATGAAATTCCAGTTATGGAATATAAGCAAATGAGCGGAAGAGCTGGTAGACCTGGTTTTGATCAGATTGGCGAG
TCAATAATTGTGGTAAGGGATAAGGAAGACGTAGATCGAGTATTTAAGAAATATATACTATCTGATGTTGAGCCCATTGA
ATCTAAACTGGGTAGTGAAAGGGCATTTTACACGTTCTTACTCGGCATACTTTCTGCTGAAGGTAGTCTGAGTGAAAAAC
AGCTGGAAGGCTTTGCATATGAATCTCTGCTTGCAAAGTCACTAGTTGACGTTTATTTTGATAGGGCCATAAGGTGGCTA
TCAGAGCATTCTTTTATCAGAGAGGAAAATAATACGTTTACTTTAACTAATTTTGGAAAGAGGGTTGCTGATCTATATAT
AAATCCATTTACTGCTGACATCATAAGAAAGGGGCTTGAGGGACATAAGGCTTCGTGTGAAATAGCTTACCTCCATTTAC
TAGCGTTTACTCCAGATGGACCATTAGTATCAGTTGGAAGGAATGAGGAAGAAGAGCTAATTGAATTGCTGGAAGACCTA
GAGTGTGAGCTGTTAGTAGAGGAACCTTATGAGGAAGACGAATATTCCCTTTACTTAAATGCGTTAAAAGTGGCGTTGAT
AATGAAGGATTGGATAGATGAAGTTGATGAAGATACCATATTGGGTAAATATAACATAGGTTCTGGAGATTTGAGAAATA
TCGTTGAAACTATGGACTGGTTAACCTATAGTGCTTACCATTTATCTAAAGAGTTAAGGTTAGATAATCACAGCGATAAA
CTTAGGATCTTGAACTTAAGAGTGACTGATGGTGTAAAGGAAGAGCTATTAGAATTAGTTCAAATAGGTGGTGTAGGTAG
GAAGAGAGCTAGATTATTGTACAATAACGGAATTAAAGGACTAGGTGATGTTGTAATGAATCCAGATAGAGTTAGGAACT
TGTTAGGCCAAAAGCTAGGTGAGAGAGTTGTCCAAGAGGCTGCAAGATTACTTAATAGATTTCATTAA

Upstream 100 bases:

>100_bases
TATAACTCTATCTACTACAATGAAAAATTTTCAACGTATTTCTTTACGGAAAATAGGGTGATAGTGCTTAAAAACCTTCT
GCGAGAAGTAAAATAAGTTT

Downstream 100 bases:

>100_bases
TTTGCCAAACGGAGAAATATTCATTGTAAGGGATGAGTGTAATACATTAAAAAGGCTTAAGCTAATCCTTTTAGCCTTGG
GTCAAGAGGTACAACTTAAC

Product: DEAD/DEAH box helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MSLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIY
VTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDP
ERGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTKKVHGDDA
IIAYTLDSLTKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGGSDEKELLKSLISKGVAYHHA
GLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGE
SIIVVRDKEDVDRVFKKYILSDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWL
SEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDGPLVSVGRNEEEELIELLEDL
ECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDNHSDK
LRILNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH

Sequences:

>Translated_715_residues
MSLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIY
VTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDP
ERGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTKKVHGDDA
IIAYTLDSLTKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGGSDEKELLKSLISKGVAYHHA
GLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGE
SIIVVRDKEDVDRVFKKYILSDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWL
SEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDGPLVSVGRNEEEELIELLEDL
ECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDNHSDK
LRILNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH
>Mature_714_residues
SLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKTLIAEMGIISFLLKNGGKAIYV
TPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLKNYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDPE
RGPVVESVTIRAKRRNLLALSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTKKVHGDDAI
IAYTLDSLTKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGGSDEKELLKSLISKGVAYHHAG
LSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVIIGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGES
IIVVRDKEDVDRVFKKYILSDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWLS
EHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDGPLVSVGRNEEEELIELLEDLE
CELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTILGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDNHSDKL
RILNLRVTDGVKEELLELVQIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH

Specific function: Unknown

COG id: COG1204

COG function: function code R; Superfamily II helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI139394648, Length=767, Percent_Identity=26.0756192959583, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI76880486, Length=466, Percent_Identity=30.68669527897, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI40217847, Length=430, Percent_Identity=31.8604651162791, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI169218225, Length=430, Percent_Identity=31.8604651162791, Blast_Score=174, Evalue=4e-43,
Organism=Homo sapiens, GI110556640, Length=770, Percent_Identity=26.6233766233766, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI130484567, Length=409, Percent_Identity=29.3398533007335, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI193211480, Length=468, Percent_Identity=28.4188034188034, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI67782311, Length=445, Percent_Identity=26.7415730337079, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI222831595, Length=96, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17537519, Length=454, Percent_Identity=32.5991189427313, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17537127, Length=440, Percent_Identity=30.2272727272727, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI86563272, Length=434, Percent_Identity=29.7235023041475, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17542826, Length=485, Percent_Identity=28.4536082474227, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71995032, Length=440, Percent_Identity=31.3636363636364, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71995036, Length=118, Percent_Identity=43.2203389830509, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI133930973, Length=207, Percent_Identity=33.3333333333333, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17552356, Length=193, Percent_Identity=33.6787564766839, Blast_Score=83, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321020, Length=613, Percent_Identity=27.8955954323002, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321710, Length=461, Percent_Identity=31.4533622559653, Blast_Score=170, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6322411, Length=495, Percent_Identity=28.2828282828283, Blast_Score=151, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI9755332, Length=503, Percent_Identity=28.4294234592445, Blast_Score=136, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6323430, Length=216, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17933644, Length=766, Percent_Identity=25.3263707571802, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24647182, Length=436, Percent_Identity=32.7981651376147, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI28574898, Length=645, Percent_Identity=26.8217054263566, Blast_Score=167, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24660651, Length=770, Percent_Identity=25.4545454545455, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17864608, Length=475, Percent_Identity=29.0526315789474, Blast_Score=142, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17933658, Length=430, Percent_Identity=27.4418604651163, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022965
- InterPro:   IPR003583
- InterPro:   IPR014014 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: 3.6.1.-

Molecular weight: Translated: 81365; Mature: 81234

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKT
CCEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCC
LIAEMGIISFLLKNGGKAIYVTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLK
HHHHHHHHHHHHHCCCCEEEEECHHHHCCCCEEEEECHHHCCEEEEEECCCCCCCCHHHC
NYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDPERGPVVESVTIRAKRRNLLA
CCCEEEEEHHHHHHHHCCCCCHHCCCCEEEEECHHHCCCCCCCCCCHHEEEEEHHCCEEE
LSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTKKVHGDDA
EHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCEECCCCE
IIAYTLDSLTKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGG
EEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
SDEKELLKSLISKGVAYHHAGLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHCCCCCCEEEE
IGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGESIIVVRDKEDVDRVFKKYIL
EEHHHHHCCCEEEEECCCCCHHHHHHCCCCCCCCHHHCCCEEEEEECHHHHHHHHHHHHH
SDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWL
CCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDG
HHHHHHCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEEECCCC
PLVSVGRNEEEELIELLEDLECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTI
CEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
LGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDNHSDKLRILNLRVTDGVKEELLELV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHH
QIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH
HHCCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLELEWMSIDDLKLPSNVIDIIKNRGIKKLNPPQTEAVKKGLLDGNRLLLTSPTGSGKT
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCC
LIAEMGIISFLLKNGGKAIYVTPLRALTNEKYLTFKDWESIGFKVAMTSGDYDTDDAWLK
HHHHHHHHHHHHHCCCCEEEEECHHHHCCCCEEEEECHHHCCEEEEEECCCCCCCCHHHC
NYDIIITTYEKLDSLWRHRPDWLNEANYFVLDELHYLNDPERGPVVESVTIRAKRRNLLA
CCCEEEEEHHHHHHHHCCCCCHHCCCCEEEEECHHHCCCCCCCCCCHHEEEEEHHCCEEE
LSATISNYKQIAKWLGAEPVATNWRPVPLMEGVMYPERKKKEYTILFRDNTTKKVHGDDA
EHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCEEEEEEECCCCCEECCCCE
IIAYTLDSLTKNGQVLVFRNSRKMAESTALKIANYMNFVSLDEKAISEILNQLDDIEEGG
EEEEEEHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
SDEKELLKSLISKGVAYHHAGLSKALRDIIEESFRKRKIKVIVATPTLAAGVNLPARTVI
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHCCCCCCEEEE
IGDIYRFNRKIVGYYDEIPVMEYKQMSGRAGRPGFDQIGESIIVVRDKEDVDRVFKKYIL
EEHHHHHCCCEEEEECCCCCHHHHHHCCCCCCCCHHHCCCEEEEEECHHHHHHHHHHHHH
SDVEPIESKLGSERAFYTFLLGILSAEGSLSEKQLEGFAYESLLAKSLVDVYFDRAIRWL
CCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SEHSFIREENNTFTLTNFGKRVADLYINPFTADIIRKGLEGHKASCEIAYLHLLAFTPDG
HHHHHHCCCCCEEEEEHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEEEECCCC
PLVSVGRNEEEELIELLEDLECELLVEEPYEEDEYSLYLNALKVALIMKDWIDEVDEDTI
CEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCE
LGKYNIGSGDLRNIVETMDWLTYSAYHLSKELRLDNHSDKLRILNLRVTDGVKEELLELV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHH
QIGGVGRKRARLLYNNGIKGLGDVVMNPDRVRNLLGQKLGERVVQEAARLLNRFH
HHCCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]