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The map label for this gene is 227826454

Identifier: 227826454

GI number: 227826454

Start: 36991

End: 37662

Strand: Direct

Name: 227826454

Synonym: M1425_0043

Alternate gene names: NA

Gene position: 36991-37662 (Clockwise)

Preceding gene: 227826450

Following gene: 227826457

Centisome position: 1.42

GC content: 31.7

Gene sequence:

>672_bases
ATGTTAAAATATTCTATGCATTTAAATATTGTCTTACTGGAAGCTAGTCTAGAACTAGTTCCAAAAGAAATAGTTAACCA
TCCAGCTGTTATTAAGAACGCTAAAAGAAGGAATAAAAAACCTGAAGAGACTTTACTAGACATTTCCTTACACTATCATG
CAATGAAAAGTTTAGAAAATAGCCATAAAAGAGGCAGACCTGATATTTTACACCAAGCCTTACTTGTAATTCTAAACGAT
CCAGTAATTAAAGGTGACCTATTTATACATACCATACAATCTAAGATAATTAAGGTAAATCCCAATATGAGGCCACCTAA
AAATTATTTGAGATTTATGGGTTTAATGGAGCAACTATTGAAATATGGAAGAATCCCTATTAATGGCGATGAGAGTCTAA
TGGAAGTTACAAATCTTACACTAGAGGAAATTGCAGCTAGATATAATTTAATATTACTATCAGAAAAGGGGGAAAAAATA
AATCCAGAAGAACTCTGTAAGTTAGATGAAAAATGGATTTTGGGAATAGGAACTTTTCCTCATGGAGACTTTTCTGAAAA
AATTTTGAGTTTAGCTAAGAAAATTTATTCTATAAGCGAATTTCAGCTAGAAACACAACAAGTTTTGTGCCGAATCTTCT
CTGCTTGTAACTCTATTTTAGGTTGGCCTTAG

Upstream 100 bases:

>100_bases
AATCTCCCTTCCTTGCAGTAATGTAAGCTAGCTCAATAAGCTCAATAATTCTCTTCTTAATCTTGTTTTTTATTCTCACG
ATAACTACTAAACCCCCTTT

Downstream 100 bases:

>100_bases
CTTTGATAGTAACTATTCCACCTGGTACCACATCTACATCTTGTATTGACAAATCATATGCCTCTGCGATTTTTGAGAAT
ATCTTTCCTGCACATAAGGT

Product: ribosome biogenesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MLKYSMHLNIVLLEASLELVPKEIVNHPAVIKNAKRRNKKPEETLLDISLHYHAMKSLENSHKRGRPDILHQALLVILND
PVIKGDLFIHTIQSKIIKVNPNMRPPKNYLRFMGLMEQLLKYGRIPINGDESLMEVTNLTLEEIAARYNLILLSEKGEKI
NPEELCKLDEKWILGIGTFPHGDFSEKILSLAKKIYSISEFQLETQQVLCRIFSACNSILGWP

Sequences:

>Translated_223_residues
MLKYSMHLNIVLLEASLELVPKEIVNHPAVIKNAKRRNKKPEETLLDISLHYHAMKSLENSHKRGRPDILHQALLVILND
PVIKGDLFIHTIQSKIIKVNPNMRPPKNYLRFMGLMEQLLKYGRIPINGDESLMEVTNLTLEEIAARYNLILLSEKGEKI
NPEELCKLDEKWILGIGTFPHGDFSEKILSLAKKIYSISEFQLETQQVLCRIFSACNSILGWP
>Mature_223_residues
MLKYSMHLNIVLLEASLELVPKEIVNHPAVIKNAKRRNKKPEETLLDISLHYHAMKSLENSHKRGRPDILHQALLVILND
PVIKGDLFIHTIQSKIIKVNPNMRPPKNYLRFMGLMEQLLKYGRIPINGDESLMEVTNLTLEEIAARYNLILLSEKGEKI
NPEELCKLDEKWILGIGTFPHGDFSEKILSLAKKIYSISEFQLETQQVLCRIFSACNSILGWP

Specific function: Involved in ribosomal biogenesis. It seems to play a role a methylation reaction in pre-rRNA processing [H]

COG id: COG1756

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NEP1 family [H]

Homologues:

Organism=Homo sapiens, GI194328699, Length=178, Percent_Identity=27.5280898876405, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323215, Length=96, Percent_Identity=37.5, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24639698, Length=195, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005304 [H]

Pfam domain/function: PF03587 EMG1 [H]

EC number: NA

Molecular weight: Translated: 25603; Mature: 25603

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYSMHLNIVLLEASLELVPKEIVNHPAVIKNAKRRNKKPEETLLDISLHYHAMKSLEN
CEEEEEEEEEEEEECHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SHKRGRPDILHQALLVILNDPVIKGDLFIHTIQSKIIKVNPNMRPPKNYLRFMGLMEQLL
HHCCCCHHHHHHHHHHHHCCCCEECHHHHEEHHHCEEEECCCCCCHHHHHHHHHHHHHHH
KYGRIPINGDESLMEVTNLTLEEIAARYNLILLSEKGEKINPEELCKLDEKWILGIGTFP
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHCCCCCEEEEECCCC
HGDFSEKILSLAKKIYSISEFQLETQQVLCRIFSACNSILGWP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKYSMHLNIVLLEASLELVPKEIVNHPAVIKNAKRRNKKPEETLLDISLHYHAMKSLEN
CEEEEEEEEEEEEECHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SHKRGRPDILHQALLVILNDPVIKGDLFIHTIQSKIIKVNPNMRPPKNYLRFMGLMEQLL
HHCCCCHHHHHHHHHHHHCCCCEECHHHHEEHHHCEEEECCCCCCHHHHHHHHHHHHHHH
KYGRIPINGDESLMEVTNLTLEEIAARYNLILLSEKGEKINPEELCKLDEKWILGIGTFP
HHCCCCCCCCHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHCCCCCEEEEECCCC
HGDFSEKILSLAKKIYSISEFQLETQQVLCRIFSACNSILGWP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]