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The map label for this gene is lldP2 [H]

Identifier: 227817987

GI number: 227817987

Start: 4956023

End: 4957573

Strand: Reverse

Name: lldP2 [H]

Synonym: BAMEG_5513

Alternate gene names: 227817987

Gene position: 4957573-4956023 (Counterclockwise)

Preceding gene: 227817989

Following gene: 227817986

Centisome position: 94.79

GC content: 39.14

Gene sequence:

>1551_bases
ATGAAGGGGTATGTGGCAGGATTTATTACAGTTGTACTGACAATTTTAGTGGCGTTATTCGCTTATAAGATGCCGTTCAC
GATGGCGATGGCAGCGACCGGATATGGTTTCTTATACGGATTATGGCCAATTGCTTGGATTATCATTATGTCGGTATTTT
TATATAAAATTTCTGTGAAAACAGGTCAATTCGATGTGATTCGTGCATCTGTATTATCCATTACGAATGACCATCGTTTA
CTCGTTATTTTAATCGGTTTTTCATTCGGAGCATTTTTAGAAGGAGCAGCAGGATTTGGTGCACCAGTAGCGATTACGGC
AGCACTTCTTGCAGGTCTTGGGTTAAATCCTTTATATGCAGCGGGTCTTTGTTTAATTGCAAATACAGCACCAGTCGCTT
TTGGAGCGATGGGAATTCCAATTACAGTTGCTGGACAAGTAACAGGTATTGATCCACATAAAATTGGACAAATGGCTGGA
CATCAATTACCGTTCTTATCATTATTTGTTCCGTTCTTTATCGTATTTTTAATGGATGGGTTAAAAGGGGTAAGACAAAC
ATGGCCTGCTTTACTTGTAGCGGGTAGTTCGTTTGCCATTACGCAGTTCATTACGGCGACATTCTTAGGGCCAGAACTTC
CGGATATTACGTCAGCACTTGTAAGTTTAGTTAGTTTAGCGCTGTTCTTAAAAGTATGGCAACCGAAAGAAATCTATCAA
TCAGGGCAAGCAAATAGTGAAGCAGCTGCGACAACAGCGGCATCGATGCCGAAATTAACGATAGGAAAAGTTGTAAAGGC
ATGGTCTCCATTTATCGTGTTAACAGTTATGGTAGTCATTTGGAGTCAAAGTTTCTTTAAAGCATTATTTGCTCCAGGAG
GCGCGTTAGAAAGTCTTGTATTTAAGTTTGAAATTCCGGGCTTGCACAATTTAGTAATGAAAGCAGAGCCGATTGTAAAT
AAACCGACGCCTTACGAGGCAATTTTGAAGTTCGATGTATTATCAGCAACTGGAACAGCAATTTTAATTGCTTGTCTCAT
TTCCATGCTGATTTTGAAAATGAGTGTAAAAGATGCAGCAGTAACATTTAAAGAAACTTTAAGCGAATTGAAAATGCCAA
TTCTATCTATTGGATTTGTATTAGGATTTGCATTTATCGCAAACTATTCTGGACTATCTTCTACACTAGCATTAGCGTTA
GCAGGAACTGGCGGGCTATTCCCGTTCTTCTCACCATTCTTAGGCTGGATTGGTGTATTCTTAACAGGGTCTGATACGTC
AGCAAATGCATTATTCTCAAATTTACAAGCGATTACAGCACAACAAGTCGGTGTATCTGAAGTACTTCTCGTTGCAGCAA
ATACAACGGGCGGTGTAACAGGAAAAATGATTTCTCCGCAATCGATTGCGATTGCTTGTGCAGCAGTTGGACTTGCTGGA
AAAGAATCAGATTTATTCCGCTTTACAGTAAAGCATAGTTTATTTTTCGTAATTATTGTTGGTATTATGACGTATGTACA
GGCTTATTATTTAACTTGGATGATTCCATAA

Upstream 100 bases:

>100_bases
TGGACACAAGTTTATGATCCGTTCGGAAACATTTGGATTTCGGCAGCGGTCGCACTTATTCCGATTATCTTTTTTTTTCT
TAGCTTTAGCAGTTTTCCGC

Downstream 100 bases:

>100_bases
AGAGCAAAAGAAATAAACTTTTCATTTTTCAGATTATCGTGTATGATGAGAAAGTATTGAAAATTAAATCAGTGATAAAC
TAGGGGTGCCTAACGTATGC

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MKGYVAGFITVVLTILVALFAYKMPFTMAMAATGYGFLYGLWPIAWIIIMSVFLYKISVKTGQFDVIRASVLSITNDHRL
LVILIGFSFGAFLEGAAGFGAPVAITAALLAGLGLNPLYAAGLCLIANTAPVAFGAMGIPITVAGQVTGIDPHKIGQMAG
HQLPFLSLFVPFFIVFLMDGLKGVRQTWPALLVAGSSFAITQFITATFLGPELPDITSALVSLVSLALFLKVWQPKEIYQ
SGQANSEAAATTAASMPKLTIGKVVKAWSPFIVLTVMVVIWSQSFFKALFAPGGALESLVFKFEIPGLHNLVMKAEPIVN
KPTPYEAILKFDVLSATGTAILIACLISMLILKMSVKDAAVTFKETLSELKMPILSIGFVLGFAFIANYSGLSSTLALAL
AGTGGLFPFFSPFLGWIGVFLTGSDTSANALFSNLQAITAQQVGVSEVLLVAANTTGGVTGKMISPQSIAIACAAVGLAG
KESDLFRFTVKHSLFFVIIVGIMTYVQAYYLTWMIP

Sequences:

>Translated_516_residues
MKGYVAGFITVVLTILVALFAYKMPFTMAMAATGYGFLYGLWPIAWIIIMSVFLYKISVKTGQFDVIRASVLSITNDHRL
LVILIGFSFGAFLEGAAGFGAPVAITAALLAGLGLNPLYAAGLCLIANTAPVAFGAMGIPITVAGQVTGIDPHKIGQMAG
HQLPFLSLFVPFFIVFLMDGLKGVRQTWPALLVAGSSFAITQFITATFLGPELPDITSALVSLVSLALFLKVWQPKEIYQ
SGQANSEAAATTAASMPKLTIGKVVKAWSPFIVLTVMVVIWSQSFFKALFAPGGALESLVFKFEIPGLHNLVMKAEPIVN
KPTPYEAILKFDVLSATGTAILIACLISMLILKMSVKDAAVTFKETLSELKMPILSIGFVLGFAFIANYSGLSSTLALAL
AGTGGLFPFFSPFLGWIGVFLTGSDTSANALFSNLQAITAQQVGVSEVLLVAANTTGGVTGKMISPQSIAIACAAVGLAG
KESDLFRFTVKHSLFFVIIVGIMTYVQAYYLTWMIP
>Mature_516_residues
MKGYVAGFITVVLTILVALFAYKMPFTMAMAATGYGFLYGLWPIAWIIIMSVFLYKISVKTGQFDVIRASVLSITNDHRL
LVILIGFSFGAFLEGAAGFGAPVAITAALLAGLGLNPLYAAGLCLIANTAPVAFGAMGIPITVAGQVTGIDPHKIGQMAG
HQLPFLSLFVPFFIVFLMDGLKGVRQTWPALLVAGSSFAITQFITATFLGPELPDITSALVSLVSLALFLKVWQPKEIYQ
SGQANSEAAATTAASMPKLTIGKVVKAWSPFIVLTVMVVIWSQSFFKALFAPGGALESLVFKFEIPGLHNLVMKAEPIVN
KPTPYEAILKFDVLSATGTAILIACLISMLILKMSVKDAAVTFKETLSELKMPILSIGFVLGFAFIANYSGLSSTLALAL
AGTGGLFPFFSPFLGWIGVFLTGSDTSANALFSNLQAITAQQVGVSEVLLVAANTTGGVTGKMISPQSIAIACAAVGLAG
KESDLFRFTVKHSLFFVIIVGIMTYVQAYYLTWMIP

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=522, Percent_Identity=66.6666666666667, Blast_Score=683, Evalue=0.0,
Organism=Escherichia coli, GI1790031, Length=516, Percent_Identity=65.8914728682171, Blast_Score=644, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 54718; Mature: 54718

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGYVAGFITVVLTILVALFAYKMPFTMAMAATGYGFLYGLWPIAWIIIMSVFLYKISVK
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
TGQFDVIRASVLSITNDHRLLVILIGFSFGAFLEGAAGFGAPVAITAALLAGLGLNPLYA
CCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHH
AGLCLIANTAPVAFGAMGIPITVAGQVTGIDPHKIGQMAGHQLPFLSLFVPFFIVFLMDG
CCHHHEECCCCHHHCCCCCCEEEECEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LKGVRQTWPALLVAGSSFAITQFITATFLGPELPDITSALVSLVSLALFLKVWQPKEIYQ
HHHHHHHCHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
SGQANSEAAATTAASMPKLTIGKVVKAWSPFIVLTVMVVIWSQSFFKALFAPGGALESLV
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHE
FKFEIPGLHNLVMKAEPIVNKPTPYEAILKFDVLSATGTAILIACLISMLILKMSVKDAA
EEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
VTFKETLSELKMPILSIGFVLGFAFIANYSGLSSTLALALAGTGGLFPFFSPFLGWIGVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHEE
LTGSDTSANALFSNLQAITAQQVGVSEVLLVAANTTGGVTGKMISPQSIAIACAAVGLAG
EECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCC
KESDLFRFTVKHSLFFVIIVGIMTYVQAYYLTWMIP
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKGYVAGFITVVLTILVALFAYKMPFTMAMAATGYGFLYGLWPIAWIIIMSVFLYKISVK
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
TGQFDVIRASVLSITNDHRLLVILIGFSFGAFLEGAAGFGAPVAITAALLAGLGLNPLYA
CCCHHHHHHHHHHCCCCCEEEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHH
AGLCLIANTAPVAFGAMGIPITVAGQVTGIDPHKIGQMAGHQLPFLSLFVPFFIVFLMDG
CCHHHEECCCCHHHCCCCCCEEEECEEECCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LKGVRQTWPALLVAGSSFAITQFITATFLGPELPDITSALVSLVSLALFLKVWQPKEIYQ
HHHHHHHCHHHEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
SGQANSEAAATTAASMPKLTIGKVVKAWSPFIVLTVMVVIWSQSFFKALFAPGGALESLV
CCCCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHE
FKFEIPGLHNLVMKAEPIVNKPTPYEAILKFDVLSATGTAILIACLISMLILKMSVKDAA
EEEECCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
VTFKETLSELKMPILSIGFVLGFAFIANYSGLSSTLALALAGTGGLFPFFSPFLGWIGVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHEE
LTGSDTSANALFSNLQAITAQQVGVSEVLLVAANTTGGVTGKMISPQSIAIACAAVGLAG
EECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCC
KESDLFRFTVKHSLFFVIIVGIMTYVQAYYLTWMIP
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]