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The map label for this gene is nupC [H]

Identifier: 227817831

GI number: 227817831

Start: 4803473

End: 4804651

Strand: Reverse

Name: nupC [H]

Synonym: BAMEG_5352

Alternate gene names: 227817831

Gene position: 4804651-4803473 (Counterclockwise)

Preceding gene: 227817832

Following gene: 227817830

Centisome position: 91.87

GC content: 34.94

Gene sequence:

>1179_bases
ATGAAGTTTGTTATGTTTCTTGTAGGATTACTCGTTGTATTTGTACTCGGTTTTCTTATAAGTGCCGATCGAAAGAAGAT
TAAGTATAAACCAATCGCAATTATGCTTGTTATTCAGTTAGCGTTATCTTATTTCTTATTAAATACGCAAGTTGGTTATA
TTTTAGTAAAAGGAATTTCAGATGGATTTGGCGCGCTTCTTGGATATGCAGAAGCTGGAATCGTTTTCGTATTTGGTGGC
CTTGTTAATAAAGGAGAGGTTTCATTCTTCTTAACAGCGTTATTACCAATCGTATTCTTTGCCGTTTTAATCGGAATTCT
GCAACACTTTAAAATTTTACCGATATTTATTCGTGCTATTGGTACTTTGTTAAGTAAAGTAAATGGTCTAGGAAAACTAG
AATCATATAACGCAGTAGCAGCTGCTATTGTTGGGCAAGCGGAAGTATTTATTACAGTAAAAGATCAATTAAGTAAAATC
CCAAAACATCGTTTATATACATTATGTGCATCTTCCATGTCGACAGTATCGATGTCAATCGTCGGTTCTTACATGAAAAT
GATCGAACCAAAATATGTAGTAACAGCACTTGTATTAAATTTATTTAGTGGTTTCATTATTATTCATATTATTAACCCGT
ACGATATTACAGAAGAAGATACACTGAAATTAGAAAATAAGAAAAAACAGTCATTCTTTGAAATGTTAAGTGAATATATT
ATGCTTGGTTTCACAATCGCGATTACAGTAGCAGCGATGTTACTTGGTTTCGTAGCGTTAATTACAGCAATCAATAGCTT
GTTTGATTCCATGTTCGGTATTACATTCCAAGCGATTTTAGGATATATTTTCTCCCCATTAGCATTCGTAATGGGTATCC
CGCAAGCAGAGATGGTAACAGCGGGACAAATTATGGCAACGAAATTAGTATCAAACGAATTTGTTGCGATGCTTGATCTT
GGAAAAGTAGCTGGTGATTTATCAGCTCGTACAGTTGGTATCCTTTCTGTATTCCTTGTATCATTTGCGAACTTCTCATC
AATCGGAATTATCGCAGGTGCAACGAAAGGTATCGATGAGAACCAATCAAATGTAGTATCATCATTCGGTCTACGCCTTG
TGTACGGTGCGACATTAGTAAGTATTCTATCAGCGATTATCGTTGGTGTTATGTTATAG

Upstream 100 bases:

>100_bases
ATTGAAGGTTTTGAAGGAGAAATGGAAAGTTCGGATTATTTCTCGTTTTGAGTGGTCAGACGTTCAACGTTAATGAAGAG
TTAAATGGAGGATTTTATTA

Downstream 100 bases:

>100_bases
AAAAAGATGGCCCTAGCTCATAGCTAGGGCTATTTTTTATGGTAAATTTGCATGAAAAAACCAATTAATTAGGAATATAT
TAACATATAAAAATCTTTTA

Product: nucleoside transporter, NupC family

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKFVMFLVGLLVVFVLGFLISADRKKIKYKPIAIMLVIQLALSYFLLNTQVGYILVKGISDGFGALLGYAEAGIVFVFGG
LVNKGEVSFFLTALLPIVFFAVLIGILQHFKILPIFIRAIGTLLSKVNGLGKLESYNAVAAAIVGQAEVFITVKDQLSKI
PKHRLYTLCASSMSTVSMSIVGSYMKMIEPKYVVTALVLNLFSGFIIIHIINPYDITEEDTLKLENKKKQSFFEMLSEYI
MLGFTIAITVAAMLLGFVALITAINSLFDSMFGITFQAILGYIFSPLAFVMGIPQAEMVTAGQIMATKLVSNEFVAMLDL
GKVAGDLSARTVGILSVFLVSFANFSSIGIIAGATKGIDENQSNVVSSFGLRLVYGATLVSILSAIIVGVML

Sequences:

>Translated_392_residues
MKFVMFLVGLLVVFVLGFLISADRKKIKYKPIAIMLVIQLALSYFLLNTQVGYILVKGISDGFGALLGYAEAGIVFVFGG
LVNKGEVSFFLTALLPIVFFAVLIGILQHFKILPIFIRAIGTLLSKVNGLGKLESYNAVAAAIVGQAEVFITVKDQLSKI
PKHRLYTLCASSMSTVSMSIVGSYMKMIEPKYVVTALVLNLFSGFIIIHIINPYDITEEDTLKLENKKKQSFFEMLSEYI
MLGFTIAITVAAMLLGFVALITAINSLFDSMFGITFQAILGYIFSPLAFVMGIPQAEMVTAGQIMATKLVSNEFVAMLDL
GKVAGDLSARTVGILSVFLVSFANFSSIGIIAGATKGIDENQSNVVSSFGLRLVYGATLVSILSAIIVGVML
>Mature_392_residues
MKFVMFLVGLLVVFVLGFLISADRKKIKYKPIAIMLVIQLALSYFLLNTQVGYILVKGISDGFGALLGYAEAGIVFVFGG
LVNKGEVSFFLTALLPIVFFAVLIGILQHFKILPIFIRAIGTLLSKVNGLGKLESYNAVAAAIVGQAEVFITVKDQLSKI
PKHRLYTLCASSMSTVSMSIVGSYMKMIEPKYVVTALVLNLFSGFIIIHIINPYDITEEDTLKLENKKKQSFFEMLSEYI
MLGFTIAITVAAMLLGFVALITAINSLFDSMFGITFQAILGYIFSPLAFVMGIPQAEMVTAGQIMATKLVSNEFVAMLDL
GKVAGDLSARTVGILSVFLVSFANFSSIGIIAGATKGIDENQSNVVSSFGLRLVYGATLVSILSAIIVGVML

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=410, Percent_Identity=26.3414634146341, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI42542381, Length=410, Percent_Identity=25.1219512195122, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI227116277, Length=409, Percent_Identity=22.7383863080685, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1788737, Length=398, Percent_Identity=58.7939698492462, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1788485, Length=410, Percent_Identity=29.7560975609756, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1788488, Length=412, Percent_Identity=30.3398058252427, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17560276, Length=395, Percent_Identity=24.8101265822785, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71991794, Length=394, Percent_Identity=23.3502538071066, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45552519, Length=403, Percent_Identity=26.302729528536, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI45552517, Length=403, Percent_Identity=26.302729528536, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19921868, Length=403, Percent_Identity=26.302729528536, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI281360430, Length=401, Percent_Identity=24.9376558603491, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42343; Mature: 42343

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVMFLVGLLVVFVLGFLISADRKKIKYKPIAIMLVIQLALSYFLLNTQVGYILVKGIS
CHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
DGFGALLGYAEAGIVFVFGGLVNKGEVSFFLTALLPIVFFAVLIGILQHFKILPIFIRAI
CHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLLSKVNGLGKLESYNAVAAAIVGQAEVFITVKDQLSKIPKHRLYTLCASSMSTVSMSI
HHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHHH
VGSYMKMIEPKYVVTALVLNLFSGFIIIHIINPYDITEEDTLKLENKKKQSFFEMLSEYI
HHHHHHHHCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MLGFTIAITVAAMLLGFVALITAINSLFDSMFGITFQAILGYIFSPLAFVMGIPQAEMVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AGQIMATKLVSNEFVAMLDLGKVAGDLSARTVGILSVFLVSFANFSSIGIIAGATKGIDE
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
NQSNVVSSFGLRLVYGATLVSILSAIIVGVML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKFVMFLVGLLVVFVLGFLISADRKKIKYKPIAIMLVIQLALSYFLLNTQVGYILVKGIS
CHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
DGFGALLGYAEAGIVFVFGGLVNKGEVSFFLTALLPIVFFAVLIGILQHFKILPIFIRAI
CHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTLLSKVNGLGKLESYNAVAAAIVGQAEVFITVKDQLSKIPKHRLYTLCASSMSTVSMSI
HHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHHH
VGSYMKMIEPKYVVTALVLNLFSGFIIIHIINPYDITEEDTLKLENKKKQSFFEMLSEYI
HHHHHHHHCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MLGFTIAITVAAMLLGFVALITAINSLFDSMFGITFQAILGYIFSPLAFVMGIPQAEMVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AGQIMATKLVSNEFVAMLDLGKVAGDLSARTVGILSVFLVSFANFSSIGIIAGATKGIDE
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCC
NQSNVVSSFGLRLVYGATLVSILSAIIVGVML
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]