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The map label for this gene is wecC [H]

Identifier: 227816622

GI number: 227816622

Start: 3738456

End: 3739076

Strand: Reverse

Name: wecC [H]

Synonym: BAMEG_4100

Alternate gene names: 227816622

Gene position: 3739076-3738456 (Counterclockwise)

Preceding gene: 227816623

Following gene: 227816621

Centisome position: 71.49

GC content: 35.43

Gene sequence:

>621_bases
ATGTGTAAGCTATTTGAAAACATTCAGCGCCTAGTTAATATTTCGTTAGTCAATGAGCTAAACACACTATGTGAAAGTTT
AGGAATTGATTTTTATGAGGCGCTTGAAGCGGCATCTACAAAACCATTTGGATTTACTCCATATTGGCCAGGTCCAGGGA
TAGGAGGACACTGTATTCCAGTAGACCCTTTATATTTTCAATGGAGAATAAAAAAGAATGGTGCAATGAGTCAATTGATT
GAAGCAGCGCATGTAATTAATGAAGAAATGCCAGAGAAAATGGTCCAGAAAGTAAAAGGTGTGGTGCAACCACCTGCAAC
GGTTTTAATTGTAGGGATTGCATATAAGAAAGATGTAAATGACTTAAGAGAATCACCAGCGTTGCCAATTATTGAATTGT
TAATAAAAGAAGGATACGAGATAGAATATCACGATCCATATATTTCTTCGGCAAAATTTGGAGATAAGGTGTACCAATCT
GTTTCTTTAAATGAACAAGCCGTTAACCAAGCGAGTTGTATTTTAATTTTAACGGATCATTCTAATATTGATTGGAAGCT
TTTTAAAGGAATAAAGCGAGTAGTAGATACACGTGGAATTGTAAAGAAGGTGAGTAAATGA

Upstream 100 bases:

>100_bases
TATTAGTGGACAAACAGAAAAGTGTAAACAAAAAGTACAGGCTTTGTATAGCACTATTTTTGATGTAGTTGTTCCAGTTA
GTTCTCCGAAGGTAGCGGAG

Downstream 100 bases:

>100_bases
GTAAGAAATGTTTAATTACAGGCGGAGCAGGATTTATTGGATCCCATTTAGCTGAAGAGTTGGTGGGAAGAGGTTATAAT
GTCACGATTGTTGATAACTT

Product: putative UDP-N-acetyl-D-mannosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MCKLFENIQRLVNISLVNELNTLCESLGIDFYEALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLI
EAAHVINEEMPEKMVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQS
VSLNEQAVNQASCILILTDHSNIDWKLFKGIKRVVDTRGIVKKVSK

Sequences:

>Translated_206_residues
MCKLFENIQRLVNISLVNELNTLCESLGIDFYEALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLI
EAAHVINEEMPEKMVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQS
VSLNEQAVNQASCILILTDHSNIDWKLFKGIKRVVDTRGIVKKVSK
>Mature_206_residues
MCKLFENIQRLVNISLVNELNTLCESLGIDFYEALEAASTKPFGFTPYWPGPGIGGHCIPVDPLYFQWRIKKNGAMSQLI
EAAHVINEEMPEKMVQKVKGVVQPPATVLIVGIAYKKDVNDLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQS
VSLNEQAVNQASCILILTDHSNIDWKLFKGIKRVVDTRGIVKKVSK

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=215, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 23121; Mature: 23121

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKLFENIQRLVNISLVNELNTLCESLGIDFYEALEAASTKPFGFTPYWPGPGIGGHCIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
VDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVGIAYKKDVN
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHH
DLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDH
HHHHCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEECC
SNIDWKLFKGIKRVVDTRGIVKKVSK
CCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MCKLFENIQRLVNISLVNELNTLCESLGIDFYEALEAASTKPFGFTPYWPGPGIGGHCIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEE
VDPLYFQWRIKKNGAMSQLIEAAHVINEEMPEKMVQKVKGVVQPPATVLIVGIAYKKDVN
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHH
DLRESPALPIIELLIKEGYEIEYHDPYISSAKFGDKVYQSVSLNEQAVNQASCILILTDH
HHHHCCCCHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEECC
SNIDWKLFKGIKRVVDTRGIVKKVSK
CCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]