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The map label for this gene is yhxA [H]

Identifier: 227815541

GI number: 227815541

Start: 2688116

End: 2689468

Strand: Reverse

Name: yhxA [H]

Synonym: BAMEG_2954

Alternate gene names: 227815541

Gene position: 2689468-2688116 (Counterclockwise)

Preceding gene: 227815542

Following gene: 227815540

Centisome position: 51.42

GC content: 38.06

Gene sequence:

>1353_bases
ATGATGAAAACGAAACAGACTGATGAATTATTAGCAAAAGATGAGCAATATGTTTGGCACGGAATGCGTCCCTTTAGTCC
AAATAGTACAATGGTAGGGGCAAAAGCAGAAGGGTGCTGGGTTGAAGATATACAAGGGAAAAGATATTTAGATGGCATGA
GTGGTCTTTGGTGTGTGAATAGTGGATATGGAAGAAAAGAGCTCGCAGAGGCGGCATATAAGCAATTACAAACATTATCA
TACTTTCCGATGTCACAATCGCATGAACCCGCTATAAAGCTTGCAGAAAAATTAAATGAGTGGCTTGGAGGGGAGTATGT
TATTTTCTTCTCTAATAGTGGTTCGGAAGCGAACGAAACAGCTTTTAAAATAGCAAGACAATACTATGCTCAAAAAGGTG
AACCACATCGTTATAAATTTATGTCACGTTACCGCGGGTATCATGGGAATACAATGGCAACGATGGCAGCGACGGGACAA
GCACAGCGTAGATATCAATATGAGCCATTTGCTTCAGGATTTTTACATGTGACGCCGCCAGATTGTTATCGTATGCCTGG
AATAGAAAGAGAGAACATTTATGATGTCGAATGTGTAAAAGAAGTAGATCGGGTCATGACATGGGAATTAAGTGAAACGA
TTGCAGCTTTTATTATGGAACCAATTATTACGGGCGGAGGCATTTTAATGCCGCCACAAGACTATATGAAAGCTGTTCAT
GAAACGTGTCAAAAACATGGTGCCTTGCTCATTAGCGATGAAGTAATTTGCGGTTTTGGACGTACAGGAAAGGCATTTGG
ATTTATGAATTATGATGTGAAACCAGATATTATTACAATGGCAAAAGGTATTACGAGTGCGTATTTACCATTATCAGCAA
CAGCTGTGAAAAGAGAAATATATGAAGCATTTAAAGGAAAAGGAGAATATGAATTCTTCCGTCATATTAATACATTTGGT
GGAAATCCTGCGGCTTGTGCATTAGCACTTAAAAACTTAGAAATTATGGAAAATGAAAATTTAATTGAGCGATCTGCACA
AATGGGTTCGCTTTTATTAGAGCAATTAAAAGAAGAAATTGGAGAACATCCACTTGTAGGGGATATTAGAGGAAAAGGTC
TACTAGTTGGAATCGAACTAGTAAATGATAAAGAGACGAAAGAGCCAATTGATAACGACAAAATTGCAAGTGTCGTAAAT
GCTTGTAAAGAAAAAGGTTTAATTATAGGGCGGAACGGTATGACAACAGCAGGATATAATAACATCTTGACTTTAGCACC
ACCGCTTGTTATTTCAAGTGAAGAAATTGCCTTTGTTATTGGAACGTTGAAGACAGCGATGGAACGTATTTAA

Upstream 100 bases:

>100_bases
GTCTTAATTTTGTGGAATGAAAATAGCAGGGAGAAATTTAAATCATCATGGCACCAGCGCAGCTTTTGTGAAAAATAAGT
TGTTATGGAAGGTGGAAGAA

Downstream 100 bases:

>100_bases
TGAATGAAGCGAGCTGTACTATACAGCTCGCTTTTGTTTATGATGTGAAATATGATAAATTTTCAAAGAGAGGGGGGATT
TATTATGAAGAAATATGATT

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLS
YFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQ
AQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAFKGKGEYEFFRHINTFG
GNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVN
ACKEKGLIIGRNGMTTAGYNNILTLAPPLVISSEEIAFVIGTLKTAMERI

Sequences:

>Translated_450_residues
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLS
YFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQ
AQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAFKGKGEYEFFRHINTFG
GNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVN
ACKEKGLIIGRNGMTTAGYNNILTLAPPLVISSEEIAFVIGTLKTAMERI
>Mature_450_residues
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLS
YFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQ
AQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIYEAFKGKGEYEFFRHINTFG
GNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVN
ACKEKGLIIGRNGMTTAGYNNILTLAPPLVISSEEIAFVIGTLKTAMERI

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=32.093023255814, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=31.1659192825112, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=33.3333333333333, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI226442705, Length=424, Percent_Identity=33.4905660377358, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=33.8383838383838, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=27.5462962962963, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=30.8868501529052, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI188536080, Length=429, Percent_Identity=24.009324009324, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI38679950, Length=429, Percent_Identity=24.009324009324, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI38679946, Length=429, Percent_Identity=24.009324009324, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=30.2540415704388, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.5084745762712, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=30.7125307125307, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=30.952380952381, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=31.3199105145414, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788044, Length=429, Percent_Identity=27.7389277389277, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786349, Length=336, Percent_Identity=25.5952380952381, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564660, Length=463, Percent_Identity=31.5334773218143, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=471, Percent_Identity=29.723991507431, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=437, Percent_Identity=28.1464530892449, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=30.9278350515464, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=23.7597911227154, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=459, Percent_Identity=30.2832244008715, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=27.6381909547739, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6324386, Length=472, Percent_Identity=27.1186440677966, Blast_Score=142, Evalue=8e-35,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=31.7865429234339, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=31.3953488372093, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21356575, Length=459, Percent_Identity=30.0653594771242, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI21357415, Length=435, Percent_Identity=28.2758620689655, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366494, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667139, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667143, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 50304; Mature: 50304

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVN
CCCCCCCHHHHHCCCHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHCCCCCEEEEC
SGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANET
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCC
DCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREI
HHHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
YEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEI
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYN
CCCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
NILTLAPPLVISSEEIAFVIGTLKTAMERI
CEEEECCCEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMKTKQTDELLAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVN
CCCCCCCHHHHHCCCHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHCCCCCEEEEC
SGYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANET
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
AFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPP
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCC
DCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVH
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHH
ETCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREI
HHHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
YEAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEI
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYN
CCCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCC
NILTLAPPLVISSEEIAFVIGTLKTAMERI
CEEEECCCEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]