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The map label for this gene is npr [H]

Identifier: 227814621

GI number: 227814621

Start: 1849105

End: 1849833

Strand: Reverse

Name: npr [H]

Synonym: BAMEG_2031

Alternate gene names: 227814621

Gene position: 1849833-1849105 (Counterclockwise)

Preceding gene: 227814622

Following gene: 227814620

Centisome position: 35.37

GC content: 31.69

Gene sequence:

>729_bases
TTGACTGCTCATGTAGATAAAAAGGGTATTATTAAAAGTGTTTCAGGGGAAAGCGCACAAAATTTAGAAAAAGAAGATTT
AAAGAATCCTATTAATTTATCAAAAGAAGAAGCAAAACAATATATTTATAAAAAGTACGGAAATGATATTAAATTTATTT
CTGAGCCAGAAGTTAAGGAAGTTATTTTTGTTGATGAAAATAATGGACAGGCTAGCAATGCATATCAAGTTACATTTGCG
GCTGCCACACCAAACTATGTATCTGGAACTTATTTAGTGGATGCCCATAATGGTGTTATGTTGAAAAATACGTTACAAGA
ATCCGATTTAAAAGTAAGTGAAGAGCAAGTTGAATCTTTAAAGGAGAATAAAAAAAGCAATTCCATATCATTAACTGGAA
CAGGAAAAGATGATTTAGGGATAACTCGCATATTTGGTATTTCTGAACAGAGTAACGGAAAATATGCGCTTGCTGATTAT
ACAAGAGGGCAAGGAATTGAAACGTACGATGTAAATTATAGAGATATTAATTTTGAAGAAAGATATTATCCTGGTATATT
AGCAACTAGCACTTCAACAACCTTTGATGATCCAAAGGCGGTCAGTGCTCATTTCTTAGCAACAAAGGTATATGATTTTT
ATAAAGACAAATATAAGCGTAATAGTTTTGATAATAAGGGAAAAAATAGTATCAGTTGTACATGCATGGCATTCAGGAGA
AACAGATGA

Upstream 100 bases:

>100_bases
GGTAGATTACAAGGTCCTTCAAAAACGTGGTTCATATGATGGGACTACACTTGTGCGTTTGTAACAAATATATGAAGGAA
AAGAAGTATATGGACACCAA

Downstream 100 bases:

>100_bases
CCCTAAAAATTGGGGGAATGCATTTAGTGCTAATATTAACAATGTGAGTATGCTTATATATGGTGATCCAATGGTTAGAG
CGTTTGACATAGCGGGCCAT

Product: thermolysin metallopeptidase, catalytic domain protein

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKEVIFVDENNGQASNAYQVTFA
AATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENKKSNSISLTGTGKDDLGITRIFGISEQSNGKYALADY
TRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRR
NR

Sequences:

>Translated_242_residues
MTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKEVIFVDENNGQASNAYQVTFA
AATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENKKSNSISLTGTGKDDLGITRIFGISEQSNGKYALADY
TRGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRR
NR
>Mature_241_residues
TAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKEVIFVDENNGQASNAYQVTFAA
ATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESLKENKKSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYT
RGQGIETYDVNYRDINFEERYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRRN
R

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 27243; Mature: 27111

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKE
CCCCCCCCCCEECCCCCCHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEE
VIFVDENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESL
EEEEECCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHH
KENKKSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEE
HHCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEECCEEECCCCC
RYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRR
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
NR
CC
>Mature Secondary Structure 
TAHVDKKGIIKSVSGESAQNLEKEDLKNPINLSKEEAKQYIYKKYGNDIKFISEPEVKE
CCCCCCCCCEECCCCCCHHCCCHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCEE
VIFVDENNGQASNAYQVTFAAATPNYVSGTYLVDAHNGVMLKNTLQESDLKVSEEQVESL
EEEEECCCCCCCCEEEEEEEECCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHH
KENKKSNSISLTGTGKDDLGITRIFGISEQSNGKYALADYTRGQGIETYDVNYRDINFEE
HHCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCCCCCEEEECCEEECCCCC
RYYPGILATSTSTTFDDPKAVSAHFLATKVYDFYKDKYKRNSFDNKGKNSISCTCMAFRR
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
NR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2290427; 2127074 [H]