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The map label for this gene is clpP1

Identifier: 227814400

GI number: 227814400

Start: 1646107

End: 1646688

Strand: Direct

Name: clpP1

Synonym: BAMEG_1808

Alternate gene names: 227814400

Gene position: 1646107-1646688 (Clockwise)

Preceding gene: 227814399

Following gene: 227814402

Centisome position: 31.47

GC content: 35.05

Gene sequence:

>582_bases
ATGAATGCAATTCCATATGTTGTAGAACAAACGAAATTAGGAGAACGTTCCTATGATATATACTCAAGGTTATTAAAAGA
CCGTATTGTTATTATCGGTTCAGAAATAAATGATCAAGTAGCGAGTAGTGTAGTAGCTCAATTATTATTTTTAGAAGCAG
AAGATGCAGAGAAAGATATATTTTTATACATTAATAGCCCAGGCGGATCAACGACAGCAGGTTTTGCTATATTAGATACG
ATGAATTTAATTAAACCAGACGTGCAAACGCTATGCATGGGCTTTGCAGCATCATTTGGTGCATTGTTATTATTATCAGG
TGCAAAAGGAAAACGATTTGCACTCCCAAATAGTGAAATTATGATTCATCAGCCACTTGGTGGTGCGCAAGGGCAAGCGA
CGGAAATCGAAATCACAGCAAAAAGAATTTTAAAGTTAAAACATGATATTAATAAAATGATTGCAGAAAAAACAGGGCAA
CCGATTGAAAGAGTAGCACATGATACAGAAAGAGATTATTTTATGACTGCAGAAGAAGCGAAGGCATATGGGATTGTAGA
TGATGTTGTTACGAAAAAATAG

Upstream 100 bases:

>100_bases
GTTACCATCTAAACAGCCAGTCTTATTATTTAATGTGAAACAACCTTCTTCCTACAGTTGTATGCTTTGCGTTGCATAAC
AATTATTGGAGGGATTTAAA

Downstream 100 bases:

>100_bases
CAGAAAGCAGGCTAGAGAGTAAAGTATATTCTCTAGCCTGTTTTATTAATCTTTTATCCATTCATCAACTAACGCTTGAT
TCTTTTTAATCCATTTTCGC

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Sequences:

>Translated_193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK
>Mature_193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=54.5454545454545, Blast_Score=205, Evalue=2e-53,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=60.6217616580311, Blast_Score=255, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=49.2146596858639, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=54.7368421052632, Blast_Score=218, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_BACAN (Q81PL4)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_845137.1
- RefSeq:   YP_019430.1
- RefSeq:   YP_028858.1
- ProteinModelPortal:   Q81PL4
- SMR:   Q81PL4
- MEROPS:   S14.001
- EnsemblBacteria:   EBBACT00000008369
- EnsemblBacteria:   EBBACT00000015150
- EnsemblBacteria:   EBBACT00000020004
- GeneID:   1086459
- GeneID:   2817074
- GeneID:   2849926
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_2788
- KEGG:   bar:GBAA_2788
- KEGG:   bat:BAS2599
- TIGR:   BA_2788
- TIGR:   GBAA_2788
- GeneTree:   EBGT00050000002046
- HOGENOM:   HBG558421
- OMA:   KHDINKI
- ProtClustDB:   CLSK916804
- BioCyc:   BANT260799:BAS2599-MONOMER
- BioCyc:   BANT261594:GBAA2788-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21179; Mature: 21179

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCE
MIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHH
KAYGIVDDVVTKK
HHHCCHHHHHCCC
>Mature Secondary Structure
MNAIPYVVEQTKLGERSYDIYSRLLKDRIVIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCE
MIHQPLGGAQGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHH
KAYGIVDDVVTKK
HHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629