Click here to switch to the map view.

The map label for this gene is hisC2

Identifier: 227814239

GI number: 227814239

Start: 1512758

End: 1513858

Strand: Direct

Name: hisC2

Synonym: BAMEG_1647

Alternate gene names: 227814239

Gene position: 1512758-1513858 (Clockwise)

Preceding gene: 227814238

Following gene: 227814240

Centisome position: 28.92

GC content: 37.6

Gene sequence:

>1101_bases
ATGCAAGTAAAAGATCAACTATCATCATTACAACCATATAAACCAGGTAAATCACCTGAACAAATGAAAGAAGTGTACGG
AGATCATTCGTTTGTTAAATTAGCATCGAATGAAAATCCATTCGGCTGTTCGCCACGAGTTTTAGATGAGTTGCAAAAAT
CGTGGTTGGATCATGCTTTATACCCTGACGGAGGTGCTACAACGCTCCGTCAAACAATTGCAAATAAGTTACATGTGAAA
ATGGAACAAGTACTTTGCGGTAGTGGTTTAGATGAAGTCATTCAAATGATAAGCAGAGCAGTACTTAAAGCAGGAGATAA
CATCGTAACGGCTGGGGCAACATTCCCGCAGTATCGTCATCATGCAATTATAGAAGGTTGCGAAGTGAAGGAAGTTGCGT
TAAATAACGGTGTATACGACTTAGACGAAATTTCTTCAGTAGTAGATAACGATACAAAAATTGTATGGATTTGTAACCCG
AACAATCCAACAGGCACATATGTGAATGACCGAAAATTAACTCAATTCATTGAAGGTATTAGTGAAAATACGTTAATTGT
CATTGATGAAGCGTACTATGAATACGTAACAGCAAAAGATTTCCCAGAGACATTACCGCTTTTAGAAAAACATAAAAATA
TTCTTGTGCTTAGAACATTTTCTAAAGCGTACGGATTAGCTTCTTTCCGCGTTGGATATGCGGTTGGACATGAAGAATTA
ATCGAAAAATTAAATGTCGTTCGTTTGCCATTTAACGTATCTTCATTAGCGCAAAAAGCAGCGACGATTGCTTTTGGTGA
TGACGAGTTTATTGAAGAAATAGTTCGTGTGAATACAGAAGGTTTACGACAATACGAAAGTTTCTGTAAGGAAAATGAAA
TTCCATTTTATCAGTCACAAACAAATTTCATCTTCTTGCCAGTAGAAAATGGTGGAGAGATTTATGAAGCATGCGCACAC
GCAGGGTTTATTATTCGTCCGTTCCCGAATGGTGTCCGCATCACAGTCGGAACAAGGGAGCAAAATGAAGGAGTGATTTC
AGTGTTACAACAACACTTTGAAAATAAAAAAAGAAAGTCTCGAGATGAGGCAAATGCGTAA

Upstream 100 bases:

>100_bases
AGTCGAACAATTCGGAAAAGATCGTATGGAGTTAATTCAACAAAACATTACGCAACATAATAAATACGCAAAAGAATTTT
AATAAAAAGGTGGTTTTAAC

Downstream 100 bases:

>100_bases
AAAGGTAGTTTTAATTGGAACGGGTTTAATCGGAGGTTCTCTCGCATTAGCAATTAAGAAGGACCACGATGTAACGATAA
CAGGTTATGATATATTTCAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVK
MEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA

Sequences:

>Translated_366_residues
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVK
MEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA
>Mature_366_residues
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHALYPDGGATTLRQTIANKLHVK
MEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRHHAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNP
NNPTGTYVNDRKLTQFIEGISENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQTNFIFLPVENGGEIYEACAH
AGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKSRDEANA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=348, Percent_Identity=30.1724137931034, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1788627, Length=229, Percent_Identity=27.0742358078603, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322075, Length=392, Percent_Identity=27.0408163265306, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_BACAN (Q81P62)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_845290.1
- RefSeq:   YP_029004.1
- RefSeq:   YP_052629.1
- ProteinModelPortal:   Q81P62
- SMR:   Q81P62
- EnsemblBacteria:   EBBACT00000010820
- EnsemblBacteria:   EBBACT00000018514
- EnsemblBacteria:   EBBACT00000022072
- GeneID:   1088520
- GeneID:   2821170
- GeneID:   2852549
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_2955
- KEGG:   bar:GBAA_2955
- KEGG:   bat:BAS2746
- TIGR:   BA_2955
- TIGR:   GBAA_2955
- GeneTree:   EBGT00050000000787
- HOGENOM:   HBG646350
- OMA:   ENTLIVI
- ProtClustDB:   PRK01533
- BioCyc:   BANT260799:BAS2746-MONOMER
- BioCyc:   BANT261594:GBAA2955-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41112; Mature: 41112

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHAL
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIANKLHVKMEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
HAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCCHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
CCCEEEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECC
TNFIFLPVENGGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEEECCCCHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEANA
CCCCCC
>Mature Secondary Structure
MQVKDQLSSLQPYKPGKSPEQMKEVYGDHSFVKLASNENPFGCSPRVLDELQKSWLDHAL
CCCHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCC
YPDGGATTLRQTIANKLHVKMEQVLCGSGLDEVIQMISRAVLKAGDNIVTAGATFPQYRH
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCCHHHH
HAIIEGCEVKEVALNNGVYDLDEISSVVDNDTKIVWICNPNNPTGTYVNDRKLTQFIEGI
HHHHCCCCCHHHHHCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHCC
SENTLIVIDEAYYEYVTAKDFPETLPLLEKHKNILVLRTFSKAYGLASFRVGYAVGHEEL
CCCEEEEEEHHHHHHHHHCCCHHHHHHHHHCCCEEEEEECHHHHCCHHHHHHHHCCHHHH
IEKLNVVRLPFNVSSLAQKAATIAFGDDEFIEEIVRVNTEGLRQYESFCKENEIPFYQSQ
HHHHCEEECCCCHHHHHHHHHEEEECCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEECC
TNFIFLPVENGGEIYEACAHAGFIIRPFPNGVRITVGTREQNEGVISVLQQHFENKKRKS
CCEEEEEECCCCHHHHHHHHCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
RDEANA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629