BacMap

Definition	Bacillus anthracis str. CDC 684, complete genome.
Accession	NC_012581
Length	5,230,115

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The map label for this gene is bcrA [H]

Identifier: 227814151

GI number: 227814151

Start: 1427946

End: 1428818

Strand: Direct

Name: bcrA [H]

Synonym: BAMEG_1559

Alternate gene names: 227814151

Gene position: 1427946-1428818 (Clockwise)

Preceding gene: 227814150

Following gene: 227814152

Centisome position: 27.3

GC content: 31.39

Gene sequence:

>873_bases
TTGGAAAACGTAATAGAACTTCAAAATGTCAGTAAATCTTTTAAAGGGTTTCAAATAAACAATTTTTCGATGGAAGTAAA
AAAAGGATTTGTTACGGGTTTTATTGGAGGAAATGGATCAGGTAAATCTACAACAATTAAAATGATTATGAATCTAATAA
ACCCGGATAGTGGAAACGTCTCCTTATTTGGCATGAACTATTCGACTGATGCGAAACGAATTAAAGAAAGAATTGGCTTC
GTTTATGACGATAATGTGTTTTATGATGAACTCACATTAAAGGAAATTACTAAAATTATTGCACCTGCTTATAAAAAATG
GGATTTTAACCAATTTACATATTATAAAGAGCTGTTCGAATTACCATTAAACAAAAAAATGAAAACATTCTCCAAAAGAA
TGAAAATGAAAGCCTCTCTCGCAATTGCCCTTTCACATCATGCTGAACTAATTATTATGGATGAACCTACATCTGGACTT
GATCCTGTATTCAGAAGAGAATTATTGGATGTTCTACAAAATATTATGCAGGATGGAGAGAAAACTATCTTTTTCTCATC
ACATATTACAACGGATTTAGACCGCATTGCCGATTATATTACATTTATTCAAAATGGGAAGCATATTTTCACAAAAGATA
TTTATGCCATTGCAGAGGATTATGTTTTAGTCAAAGGACCACTAGATTTGTTAAAGTTTGATACTGAGCGTGAATTTATT
TCTGTACGTAAGGCAAATACAGGTTTCGAGGGATTGATTGAAAATGCACATTCTATCGAAAATTTATTTGATAAGGATGT
GGTGATTGAAAAACCGAGTTTAGAGGATATTATGTATTTCATGAAAAAGGGGGATTCAAGATGCTTAATTTAA

Upstream 100 bases:

>100_bases
AAGAAAAGTTATGTGAAGCGATTCAAAATGCTAAGCAAATGGATGTTTCTTTAAATGAGCTAAAAGAAATGCTTACAATT
TTATACGAGGAGGAAAACTC

Downstream 100 bases:

>100_bases
TTAAAAAGGATTTGATTTTACAAAAAACTTTCTTGCCTGCTTATCTCTTATTTCTAGTTACCTATTTGTGGGCCGGCATG
GATGTAGCATATGTCATAAT

Product: ABC transporter, ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MENVIELQNVSKSFKGFQINNFSMEVKKGFVTGFIGGNGSGKSTTIKMIMNLINPDSGNVSLFGMNYSTDAKRIKERIGF
VYDDNVFYDELTLKEITKIIAPAYKKWDFNQFTYYKELFELPLNKKMKTFSKRMKMKASLAIALSHHAELIIMDEPTSGL
DPVFRRELLDVLQNIMQDGEKTIFFSSHITTDLDRIADYITFIQNGKHIFTKDIYAIAEDYVLVKGPLDLLKFDTEREFI
SVRKANTGFEGLIENAHSIENLFDKDVVIEKPSLEDIMYFMKKGDSRCLI

Sequences:

>Translated_290_residues
MENVIELQNVSKSFKGFQINNFSMEVKKGFVTGFIGGNGSGKSTTIKMIMNLINPDSGNVSLFGMNYSTDAKRIKERIGF
VYDDNVFYDELTLKEITKIIAPAYKKWDFNQFTYYKELFELPLNKKMKTFSKRMKMKASLAIALSHHAELIIMDEPTSGL
DPVFRRELLDVLQNIMQDGEKTIFFSSHITTDLDRIADYITFIQNGKHIFTKDIYAIAEDYVLVKGPLDLLKFDTEREFI
SVRKANTGFEGLIENAHSIENLFDKDVVIEKPSLEDIMYFMKKGDSRCLI
>Mature_290_residues
MENVIELQNVSKSFKGFQINNFSMEVKKGFVTGFIGGNGSGKSTTIKMIMNLINPDSGNVSLFGMNYSTDAKRIKERIGF
VYDDNVFYDELTLKEITKIIAPAYKKWDFNQFTYYKELFELPLNKKMKTFSKRMKMKASLAIALSHHAELIIMDEPTSGL
DPVFRRELLDVLQNIMQDGEKTIFFSSHITTDLDRIADYITFIQNGKHIFTKDIYAIAEDYVLVKGPLDLLKFDTEREFI
SVRKANTGFEGLIENAHSIENLFDKDVVIEKPSLEDIMYFMKKGDSRCLI

Specific function: Part of the binding-protein-dependent transport system for bacitracin that confer resistance to this antibiotic. Probably responsible for energy coupling to the transport system [H]

COG id: COG1131

COG function: function code V; ABC-type multidrug transport system, ATPase component

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI31657092, Length=227, Percent_Identity=28.1938325991189, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI45446740, Length=241, Percent_Identity=31.1203319502075, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI47078218, Length=241, Percent_Identity=31.1203319502075, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI116734710, Length=244, Percent_Identity=27.8688524590164, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI21536376, Length=212, Percent_Identity=28.3018867924528, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI27881501, Length=211, Percent_Identity=28.436018957346, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI30795238, Length=211, Percent_Identity=28.436018957346, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI105990541, Length=182, Percent_Identity=31.3186813186813, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI153792144, Length=199, Percent_Identity=27.1356783919598, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI27436953, Length=202, Percent_Identity=24.2574257425743, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI27477115, Length=202, Percent_Identity=26.7326732673267, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI6005701, Length=192, Percent_Identity=25, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI27262624, Length=196, Percent_Identity=28.0612244897959, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI27262626, Length=196, Percent_Identity=28.0612244897959, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI9961252, Length=204, Percent_Identity=24.5098039215686, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4505771, Length=204, Percent_Identity=24.5098039215686, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI9961250, Length=204, Percent_Identity=24.5098039215686, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI48994943, Length=227, Percent_Identity=27.3127753303965, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786319, Length=239, Percent_Identity=29.2887029288703, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081782, Length=223, Percent_Identity=28.6995515695067, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788225, Length=223, Percent_Identity=26.457399103139, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787029, Length=242, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789991, Length=236, Percent_Identity=26.271186440678, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788540, Length=190, Percent_Identity=31.5789473684211, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786253, Length=191, Percent_Identity=24.6073298429319, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788761, Length=219, Percent_Identity=26.4840182648402, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788450, Length=214, Percent_Identity=26.6355140186916, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786398, Length=223, Percent_Identity=26.457399103139, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789672, Length=216, Percent_Identity=27.3148148148148, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790190, Length=237, Percent_Identity=26.1603375527426, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788165, Length=193, Percent_Identity=27.979274611399, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789032, Length=231, Percent_Identity=26.4069264069264, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786803, Length=204, Percent_Identity=25, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790544, Length=233, Percent_Identity=22.3175965665236, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790525, Length=298, Percent_Identity=23.1543624161074, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48995001, Length=239, Percent_Identity=23.4309623430962, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790467, Length=239, Percent_Identity=22.5941422594142, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI48994997, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788472, Length=295, Percent_Identity=21.0169491525424, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786872, Length=221, Percent_Identity=28.9592760180996, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081791, Length=215, Percent_Identity=21.8604651162791, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788210, Length=218, Percent_Identity=23.8532110091743, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787792, Length=224, Percent_Identity=24.1071428571429, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789891, Length=211, Percent_Identity=24.6445497630332, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790162, Length=245, Percent_Identity=21.6326530612245, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786703, Length=204, Percent_Identity=25, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=197, Percent_Identity=26.9035532994924, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71983516, Length=197, Percent_Identity=26.9035532994924, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71983510, Length=197, Percent_Identity=26.9035532994924, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17510237, Length=225, Percent_Identity=27.1111111111111, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115533608, Length=213, Percent_Identity=26.2910798122066, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17565586, Length=194, Percent_Identity=28.3505154639175, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI193211015, Length=202, Percent_Identity=25.2475247524752, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI193211017, Length=202, Percent_Identity=25.2475247524752, Blast_Score=64, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71996809, Length=202, Percent_Identity=25.2475247524752, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI221512771, Length=210, Percent_Identity=29.5238095238095, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI281362751, Length=207, Percent_Identity=29.4685990338164, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650853, Length=207, Percent_Identity=29.4685990338164, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650855, Length=207, Percent_Identity=29.4685990338164, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI85725262, Length=196, Percent_Identity=31.1224489795918, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24582014, Length=201, Percent_Identity=28.8557213930348, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24582012, Length=201, Percent_Identity=28.8557213930348, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574150, Length=193, Percent_Identity=31.0880829015544, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI116007328, Length=193, Percent_Identity=31.0880829015544, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24643674, Length=243, Percent_Identity=27.1604938271605, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24666092, Length=227, Percent_Identity=28.6343612334802, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24648314, Length=228, Percent_Identity=25.8771929824561, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573571, Length=259, Percent_Identity=20.0772200772201, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573573, Length=206, Percent_Identity=24.2718446601942, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659289, Length=202, Percent_Identity=24.2574257425743, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363262, Length=199, Percent_Identity=23.6180904522613, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24653245, Length=199, Percent_Identity=23.6180904522613, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581407, Length=203, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 33341; Mature: 33341

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVIELQNVSKSFKGFQINNFSMEVKKGFVTGFIGGNGSGKSTTIKMIMNLINPDSGNV
CCCHHHHHHHHHHHCCEEEECCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCE
SLFGMNYSTDAKRIKERIGFVYDDNVFYDELTLKEITKIIAPAYKKWDFNQFTYYKELFE
EEEEECCCCHHHHHHHHCCEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LPLNKKMKTFSKRMKMKASLAIALSHHAELIIMDEPTSGLDPVFRRELLDVLQNIMQDGE
CCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
KTIFFSSHITTDLDRIADYITFIQNGKHIFTKDIYAIAEDYVLVKGPLDLLKFDTEREFI
EEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCEEEECCHHHHHCCCCHHHH
SVRKANTGFEGLIENAHSIENLFDKDVVIEKPSLEDIMYFMKKGDSRCLI
HHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MENVIELQNVSKSFKGFQINNFSMEVKKGFVTGFIGGNGSGKSTTIKMIMNLINPDSGNV
CCCHHHHHHHHHHHCCEEEECCEEEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCE
SLFGMNYSTDAKRIKERIGFVYDDNVFYDELTLKEITKIIAPAYKKWDFNQFTYYKELFE
EEEEECCCCHHHHHHHHCCEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LPLNKKMKTFSKRMKMKASLAIALSHHAELIIMDEPTSGLDPVFRRELLDVLQNIMQDGE
CCCCHHHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
KTIFFSSHITTDLDRIADYITFIQNGKHIFTKDIYAIAEDYVLVKGPLDLLKFDTEREFI
EEEEEECCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHCCEEEECCHHHHHCCCCHHHH
SVRKANTGFEGLIENAHSIENLFDKDVVIEKPSLEDIMYFMKKGDSRCLI
HHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7476193 [H]