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The map label for this gene is menA [H]

Identifier: 227814018

GI number: 227814018

Start: 1303741

End: 1304652

Strand: Direct

Name: menA [H]

Synonym: BAMEG_1425

Alternate gene names: 227814018

Gene position: 1303741-1304652 (Clockwise)

Preceding gene: 227814017

Following gene: 227814020

Centisome position: 24.93

GC content: 38.05

Gene sequence:

>912_bases
ATGGGGACAGAAAAAGAAATTAGTTCCGCTAAATTAATATGGAAGATGACGCGCCCGCATACGTTAACGGCGACGTTTTC
TCCTGTAATTTTAGGAACGGTGGCATCACTTTATGTTGCCAAAATTGATTGGCTTTTATTTATTGCGATGATGGTTGCAT
GTTTAGCATTGCAAATTGCAACGAACTTATTTAATGAGTACTATGATTTCAAACGTGGATTAGATACCGCTGATTCTGTT
GGCATCGGTGGCGGAATTGTCCGTCATGGATTGAAACCAAAAAATGTGTTAACAGTTGCGCTTTTATTGTATGTAGTAGC
AGCAATTATTGGAGTTTATATTTGTATGAATAGTAGCTGGTGGTTAGTCGTCATCGGTTTAATTGGAATGGCGGTTGGCT
ATTTATATACAGGTGGTCCATTACCAATTGCGTACACTCCGTTTGGAGAATTAGTTTCTGGATTGTTAATGGGGACATGT
TTTGTACTCATTGCTTTCTTTATTCAAACGAATACGATAACGACTGAAAGTGTATTGATTTCCATTCCAATTGGAATTTT
AGTCGGTGCAATCAACATGTCAAATAACATCCGGGATATCGAAGAAGATATTAAAGGTGGAAGAAAGACGTTAGTAATCC
TTCTCGGGAGAGAGAAAGCAGTGGTCACACTTGCTATAGCCTTTTTCATTGCTTATTTATGGATCGCGGTAATTGTATGG
ATGGGTTATATAAGCCCTTGGGCATTAGTGATGTTCCTAGGTTTGAGAAAGCCAATTTCTGCAATTCAAAGTTTCCAAAA
AGGAGCAAAAGATCCCGGATATATGCGCATCGCAATGAAATCAACAGCGATGACAAATACGATTTTCGGCTTCTTATTAT
CAGCAGGATTACTAATTAGTTACTTGTTTTAA

Upstream 100 bases:

>100_bases
TACCAGTTCATTTTTTGATATAATAGATGCGTGGCAGGATATAGATAGAAAGATACTGCTAGTAATTTATACTTAAAATG
TAGGGAGATCGAACTGAGTT

Downstream 100 bases:

>100_bases
ATAAAAATATGATGAAATAAATTAGCCCCAATTTCTCAATTTTAATATGGAGAGATTGGGGTTTTTATTTTGACTATGTT
TAACGTTAAGAGTCGAAATG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIATNLFNEYYDFKRGLDTADSV
GIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTC
FVLIAFFIQTNTITTESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVW
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF

Sequences:

>Translated_303_residues
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIATNLFNEYYDFKRGLDTADSV
GIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTC
FVLIAFFIQTNTITTESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVW
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF
>Mature_302_residues
GTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIATNLFNEYYDFKRGLDTADSVG
IGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSWWLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTCF
VLIAFFIQTNTITTESVLISIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVWM
GYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLISYLF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=232, Percent_Identity=30.6034482758621, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1790365, Length=298, Percent_Identity=25.8389261744966, Blast_Score=88, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17737429, Length=290, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33043; Mature: 32912

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIA
CCCCHHHHHHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLFNEYYDFKRGLDTADSVGIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSW
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
WLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTCFVLIAFFIQTNTITTESVLI
HHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHE
SIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVW
EECHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YLF
HCC
>Mature Secondary Structure 
GTEKEISSAKLIWKMTRPHTLTATFSPVILGTVASLYVAKIDWLLFIAMMVACLALQIA
CCCHHHHHHHHHEEECCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLFNEYYDFKRGLDTADSVGIGGGIVRHGLKPKNVLTVALLLYVVAAIIGVYICMNSSW
HHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
WLVVIGLIGMAVGYLYTGGPLPIAYTPFGELVSGLLMGTCFVLIAFFIQTNTITTESVLI
HHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHE
SIPIGILVGAINMSNNIRDIEEDIKGGRKTLVILLGREKAVVTLAIAFFIAYLWIAVIVW
EECHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
MGYISPWALVMFLGLRKPISAIQSFQKGAKDPGYMRIAMKSTAMTNTIFGFLLSAGLLIS
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YLF
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]