Click here to switch to the map view.

The map label for this gene is acr3 [H]

Identifier: 227814008

GI number: 227814008

Start: 1294259

End: 1295299

Strand: Direct

Name: acr3 [H]

Synonym: BAMEG_1415

Alternate gene names: 227814008

Gene position: 1294259-1295299 (Clockwise)

Preceding gene: 227814007

Following gene: 227814009

Centisome position: 24.75

GC content: 36.22

Gene sequence:

>1041_bases
ATGAAACGCTTATCTTTTCTAGACCGATATTTAACACTATGGATTTTTCTAGCGATGGCTGTTGGGATTGGTTTAGGGTT
TGTATTCCCTAGTGTAGTAGACGGACTGAATACATTACAAGTTGGAACGACGTCTATTCCGCTTGCTGTTGGTTTAATTG
TAATGATGTATCCACCATTAGCGAAAGTTCGCTATGAGGAAATGGGCCGAGTATTTAAAGATGTTAAAGTGTTAGTTTTA
TCTTTAGTACAAAACTGGATTATTGGTCCGGTACTTATGTTTGTTTTAGCAATTATTTTTCTTCCTGATAAACCAGAATA
CATGGTCGGTCTCATTATGATTGGATTAGCACGTTGCATTGCAATGGTCATTGTTTGGAACGATCTTGCCGATGGAGATA
AAGAGTATGCGGCAGGTTTAGTCGCTTTTAATTCGGTATTCCAAATGCTCTTTTTCTCGGTTTATGCATACGTATTTGTA
ACAGTCATTCCAGAATGGTTAGGGATTGAAGGGGCTATTGTCGATATTACAATGATAGAAGTAGCAAAATCAGTATTTAT
CTATTTAGGAATTCCTTTTATAGCAGGTATGTTGACACGCTTTGTACTCGTGAAGTTAAAAGGAAGACAGTGGTATGAAA
AGGTGTTTATACCTAAGATTAGTCCACTTACATTGATTGCATTGCTATTTACGATCATCATTATGTTTTCTTTAAAAGGA
GAGATGATTGTTAGTGTACCACTAGATGTAGTAAGAATAGCAATTCCATTACTCATTTATTTTATTGTAATGTTTTTTGT
TTCTTTCTTTATGGGAAGAAAGATTGGTGCAAACTATCCGGTGACTACAACATTAGCATTTACAGCAGGTAGTAATAACT
TTGAGTTAGCAATTGCTGTAGCAGTTGGTGTGTTTGGTATTCATTCCGGTGCGGCATTCGCAGCTGTTATCGGACCGTTA
GTGGAAGTACCTGTCATGATTGCACTTGTAAACGTCGCTTTTTGGTTTAAGCGTAAATATTTTAATGATCAACTAGTATA
A

Upstream 100 bases:

>100_bases
AGCACATAGTGATGTTCACAAAATTGAAGAGTCATCATGTTGCACGACTGCAAATGAGGTAGCTAAAAATTCTTGTTGTT
AATAGGAGATGGAAAATAAA

Downstream 100 bases:

>100_bases
TTTAAAAACAAAGGTGGAAAACAACATGGAAAATAAAAAGACAATCTATTTCTTATGTACGGGAAATTCATGCCGAAGCC
AAATGGCAGAAGCATGGGGC

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQLV

Sequences:

>Translated_346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQLV
>Mature_346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQLV

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=328, Percent_Identity=36.890243902439, Blast_Score=180, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38450; Mature: 38450

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCH
AKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEGAIVDITMIE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEHHHH
AVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRKYFNDQLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCH
AKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSVYAYVFVTVIPEWLGIEGAIVDITMIE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTIIIMFSLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKIGANYPVTTTLAFTAGSNNFELAIAV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEHHHH
AVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRKYFNDQLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]