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The map label for this gene is argH1 [H]

Identifier: 227813624

GI number: 227813624

Start: 924989

End: 926218

Strand: Direct

Name: argH1 [H]

Synonym: BAMEG_1028

Alternate gene names: 227813624

Gene position: 924989-926218 (Clockwise)

Preceding gene: 227813623

Following gene: 227813625

Centisome position: 17.69

GC content: 35.37

Gene sequence:

>1230_bases
GTGGAACATTTAATTTCTCAAGAAGCGAAAAGCGATTTTGTAAGTAATATGCATATTGGTAGAAGTAGAAATGATATGGG
TGTTACGATGTATCGCATGAGTTTAAGGCGATATGTGCTACGATTAATGGAACATCATTTGTTATTGCAAGAAAGTATAT
TGCAACTTGCTGCTGATCATAAGGAAACGATTATGCCAGCTTATACACATACACAACCAGCTCAGCCAACAACATTTGGT
CATTATACGTTAGCGATTTATGATACGATGCAGAGAGATTTAGAACGCATGAAAAAAACGTACAAACTTTTAAATCAGTC
CCCAATGGGAGCCGCTGCGCTTTCTACAACAAGTTTCCCAATTAAACGAGAGCGAGTTGCCGATTTACTTGGATTTACTA
ATGTAATTGAGAACTCATATGATGCTGTCGCTGGAGCGGATTATTTATTAGAGGTTAGCTCGTTACTTATGATAATGATG
ACGAATACGAGTAGATGGATTCATGATTTTTTACTATTAGCGACGAAAGAATATGATGGTATTGCAGTTGCAAGGCCGTA
TGTACAAATTAGTAGTATTATGCCACAAAAGCGAAATCCAGTTTCGATTGAACACGCCCGTGCAATTACGAGTAGTGCTC
CAGGGGAAGCATTTACAGTATTTCAAATGATTCATAATACACCATTTGGTGAGATTGTCGATACGGAAGATGACTTGCAG
CCGTATTTATATAAAGGAATTGAAAAGGCTATTCGTGTATTTTGCATTTTGAATGCAGTCATTCGAACGATGAAAGTAGA
AGAGGATACCTTAAAAAGACGTTCATATAAACATGCAATTACGATTACAGATTTCGCAGATGTTTTAACGAAAAACTATG
GCATCCCATTTCGGCATGCTCATCATGCGGCAAGTGTTATTGCGAATATGTCGTTGGAACAGAAAAAGGAGCTACATGAA
TTATGTTTCAAAGATGTAAATATATACTTACAAGAAAAATTTAAAATACAATTATTAGAAAAAGAGTGGGAAGAAATTAT
ATCGCCAGAAGCTTTTATACAAAAAAGAAATGTATATGGTGGACCGAGTAAAAAAGAAATGGAGCGCATGATTAACAATC
GAAAAGAGTTATTTCGAAAAGAAGAAGAGGTATTTGAAGAGGAAAAACAGAGGATTTTACAAGCTGAAAATGATTTGAAT
ATGTTAGCTTCGAATATTATTGAATCGTAA

Upstream 100 bases:

>100_bases
GAAGAAGCTAAATTTAATATTACACGCATTAAAAAAGGTTGAGGAAATTCCAGAAGAGCAATTGCTCTATACAGAGCAGC
ATGAAGATCTCTTTTTTTTA

Downstream 100 bases:

>100_bases
AAGAGGGATTTAATGAATTAATCGCCAATACTTAATAAAACTATAAATAGAGAGAAGAGATTGTCGATGATTCAATTACA
TGTATATGAAGAGGTTGTTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFG
HYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGADYLLEVSSLLMIMM
TNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQ
PYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHE
LCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEEEKQRILQAENDLN
MLASNIIES

Sequences:

>Translated_409_residues
MEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFG
HYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGADYLLEVSSLLMIMM
TNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQ
PYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHE
LCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEEEKQRILQAENDLN
MLASNIIES
>Mature_409_residues
MEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFG
HYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGADYLLEVSSLLMIMM
TNTSRWIHDFLLLATKEYDGIAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQ
PYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHAHHAASVIANMSLEQKKELHE
LCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEEVFEEEKQRILQAENDLN
MLASNIIES

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=313, Percent_Identity=27.4760383386581, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI68303542, Length=313, Percent_Identity=27.4760383386581, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI68303547, Length=313, Percent_Identity=28.1150159744409, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI68303549, Length=313, Percent_Identity=24.9201277955272, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790398, Length=355, Percent_Identity=29.0140845070423, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6321806, Length=377, Percent_Identity=28.6472148541114, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI221473854, Length=360, Percent_Identity=27.2222222222222, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI78706858, Length=360, Percent_Identity=27.2222222222222, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 47331; Mature: 47331

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADH
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KETIMPAYTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFP
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
IKRERVADLLGFTNVIENSYDAVAGADYLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
IAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQ
EEEECHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHH
PYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHH
HHAASVIANMSLEQKKELHELCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
GPSKKEMERMINNRKELFRKEEEVFEEEKQRILQAENDLNMLASNIIES
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADH
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KETIMPAYTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFP
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCC
IKRERVADLLGFTNVIENSYDAVAGADYLLEVSSLLMIMMTNTSRWIHDFLLLATKEYDG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
IAVARPYVQISSIMPQKRNPVSIEHARAITSSAPGEAFTVFQMIHNTPFGEIVDTEDDLQ
EEEECHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHH
PYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADVLTKNYGIPFRHA
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCHHH
HHAASVIANMSLEQKKELHELCFKDVNIYLQEKFKIQLLEKEWEEIISPEAFIQKRNVYG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
GPSKKEMERMINNRKELFRKEEEVFEEEKQRILQAENDLNMLASNIIES
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA