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The map label for this gene is deoA [H]

Identifier: 227082473

GI number: 227082473

Start: 2442653

End: 2444080

Strand: Reverse

Name: deoA [H]

Synonym: VCM66_2272

Alternate gene names: 227082473

Gene position: 2444080-2442653 (Counterclockwise)

Preceding gene: 227082474

Following gene: 227082472

Centisome position: 84.5

GC content: 52.59

Gene sequence:

>1428_bases
TTGTGTCTGAGAGCAGCGCGAGGCTTCGCGCTGCTTAACCTCTTTACACTACGCAGTTTCTTTGGGAACTGGGAGGCAGC
TATGTCTTTATCTCAAGCAAAGTATTTACCTCAAGAAATTATCCGCAGAAAGCGTGATGGTGAAGTTCTCACCAACGATG
AAATCAACTTCTTCATTCAAGGTGTGGCGAATAACACCGTCTCTGAAGGGCAAATTGCCGCGTTTGCGATGGCGATTTTT
TTCCGTGAAATGACTATGCCTGAGCGTATTGCACTGACGTGCGCGATGCGCGATTCCGGTATGGTGATTGATTGGAGCCA
CATGAATTTTGATGGTCCGATTGTGGATAAACACTCCACGGGCGGCGTGGGCGATGTGACCTCACTGATGCTTGGCCCTA
TGGTGGCAGCCTGTGGCGGTTATGTGCCGATGATTTCTGGCCGCGGCCTTGGTCACACTGGGGGGACGCTCGACAAACTT
GAAGCCATCCCCGGCTATAACATTACCCCAACCAATGACGTGTTTGGCAAAGTGACCAAACAAGCCGGCGTGGCGATCAT
CGGCCAAACTGGCGATCTGGCTCCGGCGGATAAGCGTGTGTACGCAACGCGTGATATTACCGCGACAGTGGATAACATCT
CGCTGATCACCGCTTCAATTCTTTCTAAGAAACTGGCGGCTGGCCTTGAATCGCTCGTGATGGATGTGAAAGTTGGCTCT
GGTGCTTTCATGCCAACTTACGAAGCGTCTGAAGAGCTCGCCAAATCGATCGTGGCAGTGGCCAACGGTGCAGGCACCAA
TACCACGGCGATCTTAACTGATATGAACCAAGTGCTGGCGTCTTCAGCGGGTAACGCGGTGGAAGTGCGTGAAGCAGTAC
GCTTCCTCACCGGCGAATACCGTAATCCGCGTCTGCTGGAAGTCACTATGGCGTCGTGTGCGGAAATGCTGGTACTTGGC
AAGTTAGCCAAAGATACCGCGCAAGCGCGTGAGAAACTGCAAGCAGTGCTGGATAACGGCCAAGCCGCCGAGCGTTTTGG
CAAAATGGTCGCAGGCCTCGGTGGCCCAAGCGATTTTGTTGAAAACTACGACAAGTATCTTGCGAAAGCTGAGATTGTTC
GCCCAGTTTACGCTCAGCAATCTGGCGTTATTTCTGCGATGGATACCCGTGCCATCGGCATGGCGGTGGTCGGCATGGGC
GGTGGCCGCCGCGTGGCGACCGATCGTATCGATTACGCTGTCGGTTTTGATCAGTTTATCCGTCTGGGTGAAATCGCCGA
CAGCAACAAACCTTTAGCAATGATTCATGCCCGTAATGAAGAGCAGTGGCAACAAGCTGCCAATGCACTACAAAGTGCGA
TTAAAGTGGGCGGTGATTACCTACCAACACCGGATGTTTACCGTCAAATTCGAGCACAAGACGTGTAA

Upstream 100 bases:

>100_bases
CCGTCACTACCGTTTCGGCGCTTCAAGCCTACTGACTAACCTTCTGAATACATTAGAAGTGACAGACCAAAAGGCAGATC
CTGCCGCTTACTAATATCCA

Downstream 100 bases:

>100_bases
GTTCGGGGGAGTGAGCAATGAAAAGAGCATTTATTTTAGTTTTAGACTCGTTTGGCATTGGCGCAACAGCGGATGCACAA
GCCTTTGGTGATGTCGGTTC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MCLRAARGFALLNLFTLRSFFGNWEAAMSLSQAKYLPQEIIRRKRDGEVLTNDEINFFIQGVANNTVSEGQIAAFAMAIF
FREMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKL
EAIPGYNITPTNDVFGKVTKQAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLESLVMDVKVGS
GAFMPTYEASEELAKSIVAVANGAGTNTTAILTDMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMASCAEMLVLG
KLAKDTAQAREKLQAVLDNGQAAERFGKMVAGLGGPSDFVENYDKYLAKAEIVRPVYAQQSGVISAMDTRAIGMAVVGMG
GGRRVATDRIDYAVGFDQFIRLGEIADSNKPLAMIHARNEEQWQQAANALQSAIKVGGDYLPTPDVYRQIRAQDV

Sequences:

>Translated_475_residues
MCLRAARGFALLNLFTLRSFFGNWEAAMSLSQAKYLPQEIIRRKRDGEVLTNDEINFFIQGVANNTVSEGQIAAFAMAIF
FREMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKL
EAIPGYNITPTNDVFGKVTKQAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLESLVMDVKVGS
GAFMPTYEASEELAKSIVAVANGAGTNTTAILTDMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMASCAEMLVLG
KLAKDTAQAREKLQAVLDNGQAAERFGKMVAGLGGPSDFVENYDKYLAKAEIVRPVYAQQSGVISAMDTRAIGMAVVGMG
GGRRVATDRIDYAVGFDQFIRLGEIADSNKPLAMIHARNEEQWQQAANALQSAIKVGGDYLPTPDVYRQIRAQDV
>Mature_475_residues
MCLRAARGFALLNLFTLRSFFGNWEAAMSLSQAKYLPQEIIRRKRDGEVLTNDEINFFIQGVANNTVSEGQIAAFAMAIF
FREMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKL
EAIPGYNITPTNDVFGKVTKQAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLESLVMDVKVGS
GAFMPTYEASEELAKSIVAVANGAGTNTTAILTDMNQVLASSAGNAVEVREAVRFLTGEYRNPRLLEVTMASCAEMLVLG
KLAKDTAQAREKLQAVLDNGQAAERFGKMVAGLGGPSDFVENYDKYLAKAEIVRPVYAQQSGVISAMDTRAIGMAVVGMG
GGRRVATDRIDYAVGFDQFIRLGEIADSNKPLAMIHARNEEQWQQAANALQSAIKVGGDYLPTPDVYRQIRAQDV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=435, Percent_Identity=38.8505747126437, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4503445, Length=435, Percent_Identity=38.8505747126437, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI166158922, Length=435, Percent_Identity=38.8505747126437, Blast_Score=263, Evalue=3e-70,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=71.0045662100457, Blast_Score=626, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 50902; Mature: 50902

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLRAARGFALLNLFTLRSFFGNWEAAMSLSQAKYLPQEIIRRKRDGEVLTNDEINFFIQ
CCCCHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCCEEEEE
GVANNTVSEGQIAAFAMAIFFREMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHST
ECCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCEEEECCCCCCCCEECCCCC
GGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYNITPTNDVFGKVTK
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
QAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLESLVMDVKVGS
HCCEEEEECCCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
GAFMPTYEASEELAKSIVAVANGAGTNTTAILTDMNQVLASSAGNAVEVREAVRFLTGEY
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
RNPRLLEVTMASCAEMLVLGKLAKDTAQAREKLQAVLDNGQAAERFGKMVAGLGGPSDFV
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
ENYDKYLAKAEIVRPVYAQQSGVISAMDTRAIGMAVVGMGGGRRVATDRIDYAVGFDQFI
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCEEEEECCCCCEEEHHHHHHHHCHHHHH
RLGEIADSNKPLAMIHARNEEQWQQAANALQSAIKVGGDYLPTPDVYRQIRAQDV
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MCLRAARGFALLNLFTLRSFFGNWEAAMSLSQAKYLPQEIIRRKRDGEVLTNDEINFFIQ
CCCCHHCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCCEEEEE
GVANNTVSEGQIAAFAMAIFFREMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHST
ECCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCEEEECCCCCCCCEECCCCC
GGVGDVTSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLEAIPGYNITPTNDVFGKVTK
CCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
QAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLESLVMDVKVGS
HCCEEEEECCCCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
GAFMPTYEASEELAKSIVAVANGAGTNTTAILTDMNQVLASSAGNAVEVREAVRFLTGEY
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
RNPRLLEVTMASCAEMLVLGKLAKDTAQAREKLQAVLDNGQAAERFGKMVAGLGGPSDFV
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
ENYDKYLAKAEIVRPVYAQQSGVISAMDTRAIGMAVVGMGGGRRVATDRIDYAVGFDQFI
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHCEEEEECCCCCEEEHHHHHHHHCHHHHH
RLGEIADSNKPLAMIHARNEEQWQQAANALQSAIKVGGDYLPTPDVYRQIRAQDV
HHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]