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The map label for this gene is pgm [H]

Identifier: 227082221

GI number: 227082221

Start: 2193175

End: 2194821

Strand: Reverse

Name: pgm [H]

Synonym: VCM66_2019

Alternate gene names: 227082221

Gene position: 2194821-2193175 (Counterclockwise)

Preceding gene: 227082222

Following gene: 227082219

Centisome position: 75.88

GC content: 48.82

Gene sequence:

>1647_bases
ATGGCTATGCACCCTCGTGCTGGACAAAAGGCGCGACAAGAGGATCTCCATAATATCCCTGCGCTAGTTGCAAATTACTA
CCTACTCCAGCCTGAAGCTGGCAATACGGCGCATAAAGTTGAATTTGGTACGTCGGGACACCGAGGTACGGCCGATAAAA
CTACCTTTAATGAGCATCATATTCTTGCGATTGCGCAAGCGGTAGCGGATGTGCGCCATGAACATGGTGTGACTGGCCCA
ATCTTTATTGGCAAAGATACTCATGCGCTGTCTGAACCTGCATTCAGTAGTGTTCTGGAAGTGTTGATTGCCAATGGCAT
TGAAGTGATTGTGCAAGAAAACAACGGTTACACACCAACGCCGGGCATTTCACACGCTATTTTAACGTACAACCTGAAGC
ATGCAGATAAAGCGGACGGCATTGTGATTACCCCTTCGCACAACCCGCCACAAGATGGTGGCATCAAATACAACCCACCA
CACGGTGGCCCGGCGGAAGGGGAGTTAACCCAAGCGATTGAAGATCGTGCCAATGCTTACATCAGTCAGCAGCTTGCTGG
TGTAAAACGCATGCCGATTGCGTTGGCTAAACAATCCGAGTTGCTCAAGCAAGTCGATTTGGTTAAGCCTTACGTTGATG
ATCTGGTCAATGTGGTTGATATGGCGGCAATCCAAAAGGCCAAGCTCAAAATTGGGGTCGATCCTCTGGGTGGCAGTGGC
ATTGATTACTGGCGTCAAATTGGCAACGCTTACCAACTCGATTTAACGCTGGTCAGCGAAGCCATTGATCCAAGCTTCCA
ATTCATGTCATTAGATAAAGATGGCGTGATCCGTATGGATTGCTCTTCTCCATATGCCATGGCGGGTTTGCTGGCCCTGA
AAGATGAATACGACTTGGCTTTTGGTAACGATCCTGACTACGACCGTCACGGCATTGTGACCCCTAAAGGCTTGATGAAT
CCGAATCACTTCCTCGCGGTGTGCATTGATTATCTGTACCGTCATCGTCAAGGTTGGGCGGGCCATGTTGCCGTCGGTAA
AACGCTGGTTTCCAGTGCGATGATTGATAAAGTGGTTGCCGATCTTGGCCGCGAACTGTGTGAAGTTCCAGTAGGCTTCA
AATGGTTTGTTGATGGACTCTACTCTGGTCGCTTTGGTTTTGGCGGTGAAGAGAGTGCGGGGGCTTCTTTCCTGCGTCAA
GATGGCACGCCTTGGTCTACCGACAAAGATGGGATCATTTTGTGCTTACTGGCAGCGGAAATTACCGCTGTGACCGGCAA
AAATCCGCAACAGTATTATGATGAATTGGCAGCTAAACACGGTGATTTTTATTACAGCCGTATTCAAGCCGTGGCGAATG
GTCCACAGAAGAATGTGCTAAAGAAACTGTCTCCTGAAATGGTGTCGGCTCAAACGCTAGCGGGAGATGCAATTACGGCT
CGCTTGACTCATGCTCCGGGTAATGGCGCAGCCATTGGCGGCCTCAAAGTGACTACGGATTATGGTTGGTTTGCGGCTCG
TCCATCTGGCACAGAAGATATCTATAAGATTTATTGTGAGAGCTTCAAAGGGGCTGAGCACTTAAAACAAATTGAATCTG
AAGCGCAGCAGATCGTAAACCAAGTGTTTAAAGACGCGGGTTTATAA

Upstream 100 bases:

>100_bases
GATTACAGCCCAAAATTCTGATTCAAGCCTCATAATGCGTAGTGCTACACCGCTATTATGAGGTTTTATTTTATGTGAAA
TTTAAAGAAAGGATGTCACT

Downstream 100 bases:

>100_bases
TGTGATGAAATGAATCAGGGGCGATGAGATCGCCCCTTTTTTATGTCTCTTAACGCTGTGGCCACTGGTTTGGCACAATA
AACCAGAATTTCCCAGATTC

Product: phosphoglucomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAMHPRAGQKARQEDLHNIPALVANYYLLQPEAGNTAHKVEFGTSGHRGTADKTTFNEHHILAIAQAVADVRHEHGVTGP
IFIGKDTHALSEPAFSSVLEVLIANGIEVIVQENNGYTPTPGISHAILTYNLKHADKADGIVITPSHNPPQDGGIKYNPP
HGGPAEGELTQAIEDRANAYISQQLAGVKRMPIALAKQSELLKQVDLVKPYVDDLVNVVDMAAIQKAKLKIGVDPLGGSG
IDYWRQIGNAYQLDLTLVSEAIDPSFQFMSLDKDGVIRMDCSSPYAMAGLLALKDEYDLAFGNDPDYDRHGIVTPKGLMN
PNHFLAVCIDYLYRHRQGWAGHVAVGKTLVSSAMIDKVVADLGRELCEVPVGFKWFVDGLYSGRFGFGGEESAGASFLRQ
DGTPWSTDKDGIILCLLAAEITAVTGKNPQQYYDELAAKHGDFYYSRIQAVANGPQKNVLKKLSPEMVSAQTLAGDAITA
RLTHAPGNGAAIGGLKVTTDYGWFAARPSGTEDIYKIYCESFKGAEHLKQIESEAQQIVNQVFKDAGL

Sequences:

>Translated_548_residues
MAMHPRAGQKARQEDLHNIPALVANYYLLQPEAGNTAHKVEFGTSGHRGTADKTTFNEHHILAIAQAVADVRHEHGVTGP
IFIGKDTHALSEPAFSSVLEVLIANGIEVIVQENNGYTPTPGISHAILTYNLKHADKADGIVITPSHNPPQDGGIKYNPP
HGGPAEGELTQAIEDRANAYISQQLAGVKRMPIALAKQSELLKQVDLVKPYVDDLVNVVDMAAIQKAKLKIGVDPLGGSG
IDYWRQIGNAYQLDLTLVSEAIDPSFQFMSLDKDGVIRMDCSSPYAMAGLLALKDEYDLAFGNDPDYDRHGIVTPKGLMN
PNHFLAVCIDYLYRHRQGWAGHVAVGKTLVSSAMIDKVVADLGRELCEVPVGFKWFVDGLYSGRFGFGGEESAGASFLRQ
DGTPWSTDKDGIILCLLAAEITAVTGKNPQQYYDELAAKHGDFYYSRIQAVANGPQKNVLKKLSPEMVSAQTLAGDAITA
RLTHAPGNGAAIGGLKVTTDYGWFAARPSGTEDIYKIYCESFKGAEHLKQIESEAQQIVNQVFKDAGL
>Mature_547_residues
AMHPRAGQKARQEDLHNIPALVANYYLLQPEAGNTAHKVEFGTSGHRGTADKTTFNEHHILAIAQAVADVRHEHGVTGPI
FIGKDTHALSEPAFSSVLEVLIANGIEVIVQENNGYTPTPGISHAILTYNLKHADKADGIVITPSHNPPQDGGIKYNPPH
GGPAEGELTQAIEDRANAYISQQLAGVKRMPIALAKQSELLKQVDLVKPYVDDLVNVVDMAAIQKAKLKIGVDPLGGSGI
DYWRQIGNAYQLDLTLVSEAIDPSFQFMSLDKDGVIRMDCSSPYAMAGLLALKDEYDLAFGNDPDYDRHGIVTPKGLMNP
NHFLAVCIDYLYRHRQGWAGHVAVGKTLVSSAMIDKVVADLGRELCEVPVGFKWFVDGLYSGRFGFGGEESAGASFLRQD
GTPWSTDKDGIILCLLAAEITAVTGKNPQQYYDELAAKHGDFYYSRIQAVANGPQKNVLKKLSPEMVSAQTLAGDAITAR
LTHAPGNGAAIGGLKVTTDYGWFAARPSGTEDIYKIYCESFKGAEHLKQIESEAQQIVNQVFKDAGL

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG0033

COG function: function code G; Phosphoglucomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI133922562, Length=408, Percent_Identity=27.2058823529412, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI290463102, Length=441, Percent_Identity=24.9433106575964, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI21361621, Length=436, Percent_Identity=24.5412844036697, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786904, Length=546, Percent_Identity=70.1465201465201, Blast_Score=791, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17535441, Length=436, Percent_Identity=26.3761467889908, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323752, Length=443, Percent_Identity=26.86230248307, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322722, Length=442, Percent_Identity=27.6018099547511, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17864244, Length=431, Percent_Identity=25.754060324826, Blast_Score=102, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005852 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 59346; Mature: 59215

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMHPRAGQKARQEDLHNIPALVANYYLLQPEAGNTAHKVEFGTSGHRGTADKTTFNEHH
CCCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHH
ILAIAQAVADVRHEHGVTGPIFIGKDTHALSEPAFSSVLEVLIANGIEVIVQENNGYTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCC
PGISHAILTYNLKHADKADGIVITPSHNPPQDGGIKYNPPHGGPAEGELTQAIEDRANAY
CCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
ISQQLAGVKRMPIALAKQSELLKQVDLVKPYVDDLVNVVDMAAIQKAKLKIGVDPLGGSG
HHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
IDYWRQIGNAYQLDLTLVSEAIDPSFQFMSLDKDGVIRMDCSSPYAMAGLLALKDEYDLA
HHHHHHCCCEEEEEHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCEE
FGNDPDYDRHGIVTPKGLMNPNHFLAVCIDYLYRHRQGWAGHVAVGKTLVSSAMIDKVVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
DLGRELCEVPVGFKWFVDGLYSGRFGFGGEESAGASFLRQDGTPWSTDKDGIILCLLAAE
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEHH
ITAVTGKNPQQYYDELAAKHGDFYYSRIQAVANGPQKNVLKKLSPEMVSAQTLAGDAITA
HHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCEEE
RLTHAPGNGAAIGGLKVTTDYGWFAARPSGTEDIYKIYCESFKGAEHLKQIESEAQQIVN
EEEECCCCCCEECCEEEEECCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QVFKDAGL
HHHHHCCC
>Mature Secondary Structure 
AMHPRAGQKARQEDLHNIPALVANYYLLQPEAGNTAHKVEFGTSGHRGTADKTTFNEHH
CCCCCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCHH
ILAIAQAVADVRHEHGVTGPIFIGKDTHALSEPAFSSVLEVLIANGIEVIVQENNGYTPT
HHHHHHHHHHHHHHCCCCCCEEECCCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCC
PGISHAILTYNLKHADKADGIVITPSHNPPQDGGIKYNPPHGGPAEGELTQAIEDRANAY
CCCCEEEEEEEECCCCCCCCEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHH
ISQQLAGVKRMPIALAKQSELLKQVDLVKPYVDDLVNVVDMAAIQKAKLKIGVDPLGGSG
HHHHHHCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCC
IDYWRQIGNAYQLDLTLVSEAIDPSFQFMSLDKDGVIRMDCSSPYAMAGLLALKDEYDLA
HHHHHHCCCEEEEEHHHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHHHCCCCCCEE
FGNDPDYDRHGIVTPKGLMNPNHFLAVCIDYLYRHRQGWAGHVAVGKTLVSSAMIDKVVA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
DLGRELCEVPVGFKWFVDGLYSGRFGFGGEESAGASFLRQDGTPWSTDKDGIILCLLAAE
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEHH
ITAVTGKNPQQYYDELAAKHGDFYYSRIQAVANGPQKNVLKKLSPEMVSAQTLAGDAITA
HHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCEEE
RLTHAPGNGAAIGGLKVTTDYGWFAARPSGTEDIYKIYCESFKGAEHLKQIESEAQQIVN
EEEECCCCCCEECCEEEEECCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
QVFKDAGL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8083177; 8905232; 9278503; 8011018 [H]