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The map label for this gene is sucD [H]

Identifier: 227082210

GI number: 227082210

Start: 2180222

End: 2181094

Strand: Reverse

Name: sucD [H]

Synonym: VCM66_2008

Alternate gene names: 227082210

Gene position: 2181094-2180222 (Counterclockwise)

Preceding gene: 227082211

Following gene: 227082207

Centisome position: 75.4

GC content: 48.57

Gene sequence:

>873_bases
ATGTCGATTCTTATCAATAAAGACACTAAAGTCATTTGTCAGGGTTTCACCGGTGGTCAAGGTACTTTCCACTCTGAACA
GGCGATTGCTTATGGCACACAAATGGTTGGTGGTGTATCGCCAGGTAAAGGCGGTACCACGCATCTAGGTCTACCGGTAT
TTAATACCGTTCGTGAAGCCGTTGAAGTGACTGGCGCAACCGCAACTGTTATCTACGTACCAGCACCATTTTGTAAAGAT
GCGATTCTGGAAGCGATCGATGCTGGCATCAAGCTTATTGTGACCATCACTGAAGGCATTCCTACCACTGACATGATTGA
TGTCAAAGTGAAACTGGAACAGACTGGCGTTCGTATGATTGGCCCTAACTGCCCAGGTGTGATTACACCGGATGAGTGTA
AGATTGGCATCATGCCAGGACACATTCACAAGAAAGGTAAAGTGGGTATCGTTTCTCGCTCTGGTACTTTGACTTATGAA
GCGGTTAAACAAACCACAGACGAAGGTTTCGGCCAGTCTACCTGTGTGGGCATCGGTGGCGACCCAATTCCGGGGTCAAA
CTTCATCGACATCCTGAAGATGTTCCAAGAAGATCCAGCGACTGAAGCGATTGTGATGATCGGTGAAATCGGCGGTACCG
CGGAAGAAGAAGCAGCTGCTTTCATCAAAGCCAACGTCACAAAACCTGTCGTTTCTTATATCGCAGGTGTAACGGCTCCT
CCGGGCAAACGCATGGGTCATGCTGGTGCGATCATCTCTGGTGGTAAAGGTACCGCTGAAGAGAAATTTGCAGCACTTGA
GTCTGCGGGCGTGAAGACAGTAAAAAGTCTTGCCGATATTGGCAAAGCGCTGCGTGAAGTGACTGGCTGGTAA

Upstream 100 bases:

>100_bases
TTGGACGTAAAGTACTGGCAGAATCAGGTCTAGATATTATTGCAGCTGTATCTTTGACAGACGCAGCGCAAAAAGTAGTT
GCCGCGGCGGAGGGCAAATA

Downstream 100 bases:

>100_bases
TCTACCGCGATTACTTACTCAGATAATAAGAAACCCCGAACACAGCTTCGGGGTTTCTTTTTACTAAATGCCATTTCTTT
TTACTAAAAGCTAATCTGAT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSILINKDTKVICQGFTGGQGTFHSEQAIAYGTQMVGGVSPGKGGTTHLGLPVFNTVREAVEVTGATATVIYVPAPFCKD
AILEAIDAGIKLIVTITEGIPTTDMIDVKVKLEQTGVRMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKMFQEDPATEAIVMIGEIGGTAEEEAAAFIKANVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEEKFAALESAGVKTVKSLADIGKALREVTGW

Sequences:

>Translated_290_residues
MSILINKDTKVICQGFTGGQGTFHSEQAIAYGTQMVGGVSPGKGGTTHLGLPVFNTVREAVEVTGATATVIYVPAPFCKD
AILEAIDAGIKLIVTITEGIPTTDMIDVKVKLEQTGVRMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKMFQEDPATEAIVMIGEIGGTAEEEAAAFIKANVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEEKFAALESAGVKTVKSLADIGKALREVTGW
>Mature_289_residues
SILINKDTKVICQGFTGGQGTFHSEQAIAYGTQMVGGVSPGKGGTTHLGLPVFNTVREAVEVTGATATVIYVPAPFCKDA
ILEAIDAGIKLIVTITEGIPTTDMIDVKVKLEQTGVRMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEA
VKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKMFQEDPATEAIVMIGEIGGTAEEEAAAFIKANVTKPVVSYIAGVTAPP
GKRMGHAGAIISGGKGTAEEKFAALESAGVKTVKSLADIGKALREVTGW

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=68.3098591549296, Blast_Score=331, Evalue=4e-91,
Organism=Homo sapiens, GI38569423, Length=260, Percent_Identity=33.4615384615385, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI38569421, Length=260, Percent_Identity=33.4615384615385, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786949, Length=287, Percent_Identity=87.1080139372822, Blast_Score=504, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=64.2361111111111, Blast_Score=349, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=63.448275862069, Blast_Score=342, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17557344, Length=256, Percent_Identity=30.46875, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17551266, Length=256, Percent_Identity=29.6875, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=53.0612244897959, Blast_Score=285, Evalue=7e-78,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=61.0344827586207, Blast_Score=345, Evalue=2e-95,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=62.5, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI281363475, Length=259, Percent_Identity=28.957528957529, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363473, Length=259, Percent_Identity=28.957528957529, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281363477, Length=259, Percent_Identity=28.957528957529, Blast_Score=102, Evalue=2e-22,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29941; Mature: 29810

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILINKDTKVICQGFTGGQGTFHSEQAIAYGTQMVGGVSPGKGGTTHLGLPVFNTVREA
CEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
VEVTGATATVIYVPAPFCKDAILEAIDAGIKLIVTITEGIPTTDMIDVKVKLEQTGVRMI
HHHCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEEEEEECCEEEE
GPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKMFQEDPATEAIVMIGEIGGTAEEEAAAFIKANVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEEKFAALESAGVKTVKSLADIGKALREVTGW
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SILINKDTKVICQGFTGGQGTFHSEQAIAYGTQMVGGVSPGKGGTTHLGLPVFNTVREA
EEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
VEVTGATATVIYVPAPFCKDAILEAIDAGIKLIVTITEGIPTTDMIDVKVKLEQTGVRMI
HHHCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEEEEEEECCEEEE
GPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKMFQEDPATEAIVMIGEIGGTAEEEAAAFIKANVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEEKFAALESAGVKTVKSLADIGKALREVTGW
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]