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The map label for this gene is 227082169

Identifier: 227082169

GI number: 227082169

Start: 2136657

End: 2137577

Strand: Reverse

Name: 227082169

Synonym: VCM66_1966

Alternate gene names: NA

Gene position: 2137577-2136657 (Counterclockwise)

Preceding gene: 227082170

Following gene: 227082166

Centisome position: 73.9

GC content: 49.62

Gene sequence:

>921_bases
ATGATCCCACTGATTTACCATCCTATTTATTCACAACTGGATTTGCCTGTGGGGCATCGTTATCCGATCAATAAGTATCG
CCTGCTTTACGAAGAGATTGTGCGTCAAAGAGAGCAAAGTGAAGCATGGCAAGCGAGCTTCGAGTTTCATACCCCCATTG
CGGCCGAGCTTTCACGCATCACGCGATTGCATGACCCAGATTATGTGCAAGCTTTGCTCGAGGGGACGCTATCCGCGGCC
AAGATGCGTCGAATCGGATTTCCTTGGAGCAAACCACTGATTGAGCGTACTTTGTACTCGGTGGGAGGAACCTGCCTCAC
GGTTGAGCAAGCGTTGCAATCAGGGGTGGCAATTCATCTCAGTGGGGGTTATCACCATGCTCACGCCGATTTTGGTAGCG
GTTTCTGTCTGTTCAATGATCTGGCGATAGCCGCGCACTTCGCACTCTCTTTGCCTAGTGTTGATAAAGTTCTGATCATT
GACAGTGATGTACATCATGGTGACGGCACGGCAACCTTGTGCGCGGAACGTGACGAGATCATTACGCTCTCTTTTCACTG
TGATAAGAATTTTCCGGCGCGTAAGCCTGCTTCTAGTATGGATGTCGGATATGCTAACCAGACGGGCGATGAAGAGTTTT
TGTCCACTTTCATCCAAGTGGTGGAAATGGCGGTCAATCTCCATCGACCTGATCTGATCCTCTATGACGCCGGTGTGGAT
ATTCATAACGATGATGAGCTAGGTTATTTATCCATTTCACAGGCCGCTATCGCGCAACGAGATCGTTTTATGTTGGGTTT
GGCAAAGCAGGAGAGCATTCCAATCGCTTGTGTCATAGGCGGTGGGTATCGCGAAGACCATACGGCACTCGTGCCATTGC
ATCTTGAGTTACTGAAAGCGGCGTTAAGCGCAGGGTATTGA

Upstream 100 bases:

>100_bases
CTTTGCCAGCGGTGAGTAAACCTGCCTTTAAGCGCACACGCCGTGCACCAAAGAGTAAAGCCAGAACGTATAAAGCTTAA
TAAACCCAGAGCAGAGCAAA

Downstream 100 bases:

>100_bases
AGCGAAATGATGGCCGTGCGTAAAAGCAAAAAGCCGCTGAATTATCAGCGGCTTTTCTAATGTGGCGGAGAGATAGGGAT
TTGAACCCTAGGATAGCTAT

Product: histone deacetylase/AcuC/AphA family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MIPLIYHPIYSQLDLPVGHRYPINKYRLLYEEIVRQREQSEAWQASFEFHTPIAAELSRITRLHDPDYVQALLEGTLSAA
KMRRIGFPWSKPLIERTLYSVGGTCLTVEQALQSGVAIHLSGGYHHAHADFGSGFCLFNDLAIAAHFALSLPSVDKVLII
DSDVHHGDGTATLCAERDEIITLSFHCDKNFPARKPASSMDVGYANQTGDEEFLSTFIQVVEMAVNLHRPDLILYDAGVD
IHNDDELGYLSISQAAIAQRDRFMLGLAKQESIPIACVIGGGYREDHTALVPLHLELLKAALSAGY

Sequences:

>Translated_306_residues
MIPLIYHPIYSQLDLPVGHRYPINKYRLLYEEIVRQREQSEAWQASFEFHTPIAAELSRITRLHDPDYVQALLEGTLSAA
KMRRIGFPWSKPLIERTLYSVGGTCLTVEQALQSGVAIHLSGGYHHAHADFGSGFCLFNDLAIAAHFALSLPSVDKVLII
DSDVHHGDGTATLCAERDEIITLSFHCDKNFPARKPASSMDVGYANQTGDEEFLSTFIQVVEMAVNLHRPDLILYDAGVD
IHNDDELGYLSISQAAIAQRDRFMLGLAKQESIPIACVIGGGYREDHTALVPLHLELLKAALSAGY
>Mature_306_residues
MIPLIYHPIYSQLDLPVGHRYPINKYRLLYEEIVRQREQSEAWQASFEFHTPIAAELSRITRLHDPDYVQALLEGTLSAA
KMRRIGFPWSKPLIERTLYSVGGTCLTVEQALQSGVAIHLSGGYHHAHADFGSGFCLFNDLAIAAHFALSLPSVDKVLII
DSDVHHGDGTATLCAERDEIITLSFHCDKNFPARKPASSMDVGYANQTGDEEFLSTFIQVVEMAVNLHRPDLILYDAGVD
IHNDDELGYLSISQAAIAQRDRFMLGLAKQESIPIACVIGGGYREDHTALVPLHLELLKAALSAGY

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI217272877, Length=205, Percent_Identity=30.2439024390244, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI209862883, Length=205, Percent_Identity=30.2439024390244, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13128860, Length=260, Percent_Identity=26.9230769230769, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI13128864, Length=206, Percent_Identity=30.0970873786408, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI8923769, Length=260, Percent_Identity=26.1538461538462, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI293336691, Length=230, Percent_Identity=25.6521739130435, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI13128862, Length=255, Percent_Identity=26.2745098039216, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI153085395, Length=176, Percent_Identity=31.25, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI30795204, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI62750347, Length=176, Percent_Identity=30.1136363636364, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI62750349, Length=176, Percent_Identity=30.1136363636364, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI30795202, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI17158039, Length=146, Percent_Identity=30.8219178082192, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI169234807, Length=149, Percent_Identity=32.8859060402685, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI148539870, Length=149, Percent_Identity=32.8859060402685, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI262073092, Length=145, Percent_Identity=31.7241379310345, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193207430, Length=316, Percent_Identity=27.2151898734177, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=176, Percent_Identity=34.0909090909091, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193206283, Length=176, Percent_Identity=34.0909090909091, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540334, Length=175, Percent_Identity=34.2857142857143, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17537347, Length=190, Percent_Identity=29.4736842105263, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561978, Length=266, Percent_Identity=25.5639097744361, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17508561, Length=254, Percent_Identity=27.5590551181102, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534739, Length=205, Percent_Identity=30.7317073170732, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25154022, Length=160, Percent_Identity=32.5, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25154020, Length=160, Percent_Identity=32.5, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321244, Length=297, Percent_Identity=25.2525252525253, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323999, Length=276, Percent_Identity=28.9855072463768, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324307, Length=203, Percent_Identity=28.0788177339901, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649807, Length=247, Percent_Identity=25.9109311740891, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24644244, Length=268, Percent_Identity=27.2388059701493, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24657891, Length=260, Percent_Identity=26.5384615384615, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641720, Length=197, Percent_Identity=30.9644670050761, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281360799, Length=197, Percent_Identity=30.9644670050761, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI281360899, Length=173, Percent_Identity=30.0578034682081, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24642142, Length=173, Percent_Identity=30.0578034682081, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281360801, Length=197, Percent_Identity=30.9644670050761, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24642144, Length=173, Percent_Identity=30.0578034682081, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24642146, Length=173, Percent_Identity=30.0578034682081, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33926; Mature: 33926

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLIYHPIYSQLDLPVGHRYPINKYRLLYEEIVRQREQSEAWQASFEFHTPIAAELSRI
CCCEEECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHH
TRLHDPDYVQALLEGTLSAAKMRRIGFPWSKPLIERTLYSVGGTCLTVEQALQSGVAIHL
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEHHHHHHCCEEEEE
SGGYHHAHADFGSGFCLFNDLAIAAHFALSLPSVDKVLIIDSDVHHGDGTATLCAERDEI
ECCEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCE
ITLSFHCDKNFPARKPASSMDVGYANQTGDEEFLSTFIQVVEMAVNLHRPDLILYDAGVD
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
IHNDDELGYLSISQAAIAQRDRFMLGLAKQESIPIACVIGGGYREDHTALVPLHLELLKA
CCCCCCCCEEEEHHHHHHHHHHHEEEECCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHH
ALSAGY
HHHCCC
>Mature Secondary Structure
MIPLIYHPIYSQLDLPVGHRYPINKYRLLYEEIVRQREQSEAWQASFEFHTPIAAELSRI
CCCEEECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHH
TRLHDPDYVQALLEGTLSAAKMRRIGFPWSKPLIERTLYSVGGTCLTVEQALQSGVAIHL
HHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEHHHHHHCCEEEEE
SGGYHHAHADFGSGFCLFNDLAIAAHFALSLPSVDKVLIIDSDVHHGDGTATLCAERDEI
ECCEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCE
ITLSFHCDKNFPARKPASSMDVGYANQTGDEEFLSTFIQVVEMAVNLHRPDLILYDAGVD
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
IHNDDELGYLSISQAAIAQRDRFMLGLAKQESIPIACVIGGGYREDHTALVPLHLELLKA
CCCCCCCCEEEEHHHHHHHHHHHEEEECCCCCCCEEEEECCCCCCCCEEEEHHHHHHHHH
ALSAGY
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7678591 [H]