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The map label for this gene is lpxK

Identifier: 227082007

GI number: 227082007

Start: 1957888

End: 1958898

Strand: Reverse

Name: lpxK

Synonym: VCM66_1801

Alternate gene names: 227082007

Gene position: 1958898-1957888 (Counterclockwise)

Preceding gene: 227082008

Following gene: 227082006

Centisome position: 67.72

GC content: 51.34

Gene sequence:

>1011_bases
GTGGTGATAGAAAAGATCTGGTTTCACCGCCATCCATTGGGTTATTTGTTATGGCCACTGTTGTGGCCATTCAGCGTACT
ATTTGGTGTCATCAGCCGCTCACGGCGTAAAGCATATCAAACGGGCGACAAACCCTCCTATCGTGCACCCTTACCCGTGG
TCGTGGTGGGTAACATTACAGCCGGTGGTAATGGCAAAACCCCTGTTGTGGTTTGGCTGGTGGAAACGCTGCAAAACCTT
GGCTATCGTCCGGGGGTCGTTTCACGTGGTTATGGCGCTAAAGCGCCCAGCTATCCGCTCGTGGTGAATGAGCAAACGCC
AGCTCAGCATTGCGGTGATGAGCCGAAACTCATTTTTCAGCGTACCAAAGCGCCTGTAGCGGTCGATCCTGTACGCAGCC
AAGCGGTAAAAGCGCTGCTTGAGCACGGGGTCAATGTCATCGTTACGGATGATGGCTTGCAGCACTATGCGCTGCAGCGC
GATATTGAAATTGCAGTAGTGGACGGCGTTCGCCGTTTCGGTAACCAGGAATTGATCCCTTTAGGTCCTCTGCGTGAACC
TGTCAGCCGACTCGATGAAGTCGATTTCATTATCACTAATGGTGGCGTGGCAAAGGCCAATGAAATCGCAATGCGTCTGC
AACCGACGGATGCGGTGAATCTTAAGACGGGTGAACGCTGTGCAGTGAGTAAGCTCACTCGCTTGTGCGCCATGGCTGGG
ATTGGCCATCCTTCCCGATTTTTTAATACTTTGCGTGAACTCAATGCCGATTTAGTTCATTGCCAAGGTTTTGCCGATCA
TCAAGCCTTTGATGCTGCTCAGTTAAATCAACTGGCGCAGCAAGGCGCTCATCTGATCATGACAGAAAAAGATGCCGTAA
AATGCGCTGAGTTTGCCCAGCCAAATTGGTGGTATCTGCCCGTTTCGGCTCAGTTTGCTCCAGAAGCGGAGCAGCGTATT
GTGGACAAAATTAAAGAGGTAATGGAACCGTATGGATCACCGTCTGCTTGA

Upstream 100 bases:

>100_bases
TGGTTGATGAAGGTGAAATCATTGAGCGTGGTCGCCATGCTGATCTGTTGGCGCAAGATGGCGCATACGCTCAGCTGCAT
CGCATCCAGTTTGGTGAATA

Downstream 100 bases:

>100_bases
AATCGTCGCTTGCCCAGTATGTAAAGGTAAGCTGACTTACGATAAAGATCGCCAAGAGCTGATTTGTAAGCTGGATCGTC
TGGCTTATCCCATTAAAGAA

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNITAGGNGKTPVVVWLVETLQNL
GYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQRTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQR
DIEIAVVDGVRRFGNQELIPLGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGAHLIMTEKDAVKCAEFAQPNWWYLPVSAQFAPEAEQRI
VDKIKEVMEPYGSPSA

Sequences:

>Translated_336_residues
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNITAGGNGKTPVVVWLVETLQNL
GYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQRTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQR
DIEIAVVDGVRRFGNQELIPLGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGAHLIMTEKDAVKCAEFAQPNWWYLPVSAQFAPEAEQRI
VDKIKEVMEPYGSPSA
>Mature_336_residues
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNITAGGNGKTPVVVWLVETLQNL
GYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQRTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQR
DIEIAVVDGVRRFGNQELIPLGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGAHLIMTEKDAVKCAEFAQPNWWYLPVSAQFAPEAEQRI
VDKIKEVMEPYGSPSA

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=56, Blast_Score=358, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_VIBCH (Q9KQX0)

Other databases:

- EMBL:   AE003852
- PIR:   C82146
- RefSeq:   NP_231511.1
- GeneID:   2613631
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC1877
- TIGR:   VC_1877
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- ProtClustDB:   PRK00652
- BRENDA:   2.7.1.130
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37128; Mature: 37128

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNIT
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
AGGNGKTPVVVWLVETLQNLGYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQ
ECCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCCCHHHHH
RTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQRDIEIAVVDGVRRFGNQELIP
HCCCCEEECHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCEEEEEHHHHHHCCCCCCC
LGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
CCCHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGAHLIMTEKDAVKCAEFAQ
CCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCC
PNWWYLPVSAQFAPEAEQRIVDKIKEVMEPYGSPSA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVIEKIWFHRHPLGYLLWPLLWPFSVLFGVISRSRRKAYQTGDKPSYRAPLPVVVVGNIT
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEE
AGGNGKTPVVVWLVETLQNLGYRPGVVSRGYGAKAPSYPLVVNEQTPAQHCGDEPKLIFQ
ECCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHCCCCCHHHHH
RTKAPVAVDPVRSQAVKALLEHGVNVIVTDDGLQHYALQRDIEIAVVDGVRRFGNQELIP
HCCCCEEECHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCEEEEEHHHHHHCCCCCCC
LGPLREPVSRLDEVDFIITNGGVAKANEIAMRLQPTDAVNLKTGERCAVSKLTRLCAMAG
CCCHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHC
IGHPSRFFNTLRELNADLVHCQGFADHQAFDAAQLNQLAQQGAHLIMTEKDAVKCAEFAQ
CCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHCC
PNWWYLPVSAQFAPEAEQRIVDKIKEVMEPYGSPSA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301