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The map label for this gene is tlpA [H]

Identifier: 227081997

GI number: 227081997

Start: 1946807

End: 1948687

Strand: Reverse

Name: tlpA [H]

Synonym: VCM66_1791

Alternate gene names: 227081997

Gene position: 1948687-1946807 (Counterclockwise)

Preceding gene: 227082004

Following gene: 227081993

Centisome position: 67.37

GC content: 47.26

Gene sequence:

>1881_bases
ATGGATGTAACGCAACTTTCACAAAAGCAAAAAATCACCTTATTTATCCTTGTACTTTGCTTGGGCTTCATCGGGTTAGC
GGTTTTTACCGCGCAAAGTTTATCTAAGATGAACTCGCAGTATCAACAAAGTGGCGATGTGACCGCGGGCTCTGCGGCTT
TATTTGCGACTCAAGCACAGCTGTTTGAGTTAGCCGCTGAGCGTGAACATCTCTCGTCAAACAAGGTGTCTGAGATTAAA
ACGCGCTTGGCTCAGCTAATGCAGAAAGTGGAAGGGGATAAGCGCTTTCTTGCCGAGAATAACTTTGCTAATGAAGGTAA
CGCTTTACAGCAAGCGGTGCAGGCTTTTAACGACGATATGCAGCCGTGGCTTGAGATTAAAGGCGAGCTTGGTTTTAACG
TCGATGATGGCAAGTTGGCCGAGCTGAAAAAACTGGCGGTGACTATAGAAAAGAAAATTGATGAAACCGGTATGGTAACC
ATCAATTCCGATTTTCAAGCCATGATCAAAGCCCAGCAAAATTACTTACTACAACCGAATGAACAAAATTTGCGCTTATT
TAATCGGGCGTTAGCGGGTTTTGTCAGCATGTCGCAATCCTATGCCATGCTCGATCTGTATAAAGCGGAAATTGAGCAGT
TTAAAACCACTTTTTTGCGAGTCAGTGAGCTGTCGCAGCAAGTCAAAGATATCGAAAAAAACTTACTCAGTAGTGAAGCA
ACAGCGCAAGGTGTGATTGAATCAACCGCGCAGCGTCTAGAAGAGGTGAGTAGTCGTTATCAATCGTTAGCTGAGAAAGC
GGGCGAGCAAACCTTGCTCTCTATTTTAGTCGCTTGCGTGATTCTGGCAGTGTTGACCGTATTGCTGTTTATGATGGTGA
GTTTCTCGCTATCTAAAGCGTTAACACAGATAGGCCGCGTATTAGAAAAGCTCTCTTCTGGCGATCTCTCTCAGCGCTTA
GCTCTGATATCCAATAAAAAAGATGAGTTTAATCAGTTAGCGTTTGCGGTGAACAAGAGTTGTGAAAACCTCGGCGGCCT
AGTGCATGTCGTGCAAGATCGTAGTGTGGCATTGTCAGGGGATGCTGTGGCGCTCAATCAAGCGATTGATAATCTGGTAC
GCGGTCAGTCTGATGTGATGGATCAAACCCAAAGGCTCGCGTCAGCAACCGAAGAGGTCAGTTTAACCACGCAGCAAGTC
TCTCATTCTCTCGAAGTGGTCGCCAATGTGAGTAAAGCCTCGACTTTAGCGGCTGCGGAAGGCAGTAAAGTTATTAGTGC
TGCGATTGGCTCTTTGCGTGAGGTCGGGAGTATTTTGCAGTCAGCCGCCAGCCATATTCAGCAGCTAGAACAAGCTTCCG
CCAAAGTCGACTCAGTGATGGACATCATTAACGGTATCGCAGAGCAAACGAATTTATTGGCACTCAATGCGGCGATTGAA
GCTGCTCGTGCGGGTGAGCAAGGACGCGGATTTGCGGTTGTCGCCGATGAGGTGCGTAGTTTAGCCGTCAGAACGGTGAA
TGCGGTGAGCGAAATTTCCGGCACGATAGAAACTATGAAAAAAGAGAGTGCGGAAGTGATTTTGTTTATGAACCAATCCG
AGCAGACCATGGAAGAGGGGCAAAGCAAAGGCAATCAAGCCATGCAAGCGTTACAGCGAATTACCCAAGGGACGGATGAA
GCCGCATCGCAAACGGAAAGAATTTTTTCGTCGATAAAAGAGCTGTCCGCAACCAGCCAAGCAATGGCCGAAAGCATGAG
CCAAATTTCGAGTGCGATGCAAGCGTTGGAGTCGTATAACACTCAACTGCGTGTGACCAGCCGTGAAGTTGAGACACGCG
CAGAGAGTTTAGAGCATGATTGCCGACGCTTTACGTTGTAG

Upstream 100 bases:

>100_bases
CTAAACTTTTGCTATCCATAAGAAAGAGTATCTGTTGTCAGTGGGCAAGCTGGCGAACTGAACAGTGCAGTGATGCAGTA
TTTAAAAAGGAAGTGAAAAG

Downstream 100 bases:

>100_bases
AGCCTCGATTGTCCACCCTAGAAGAAGGCGTACAGCGCCACGTTACCGGTACCGCTAATCGACTCTTTATCTTCTTTAAA
TTCAGGAGTGTTAGCGGTGA

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MDVTQLSQKQKITLFILVLCLGFIGLAVFTAQSLSKMNSQYQQSGDVTAGSAALFATQAQLFELAAEREHLSSNKVSEIK
TRLAQLMQKVEGDKRFLAENNFANEGNALQQAVQAFNDDMQPWLEIKGELGFNVDDGKLAELKKLAVTIEKKIDETGMVT
INSDFQAMIKAQQNYLLQPNEQNLRLFNRALAGFVSMSQSYAMLDLYKAEIEQFKTTFLRVSELSQQVKDIEKNLLSSEA
TAQGVIESTAQRLEEVSSRYQSLAEKAGEQTLLSILVACVILAVLTVLLFMMVSFSLSKALTQIGRVLEKLSSGDLSQRL
ALISNKKDEFNQLAFAVNKSCENLGGLVHVVQDRSVALSGDAVALNQAIDNLVRGQSDVMDQTQRLASATEEVSLTTQQV
SHSLEVVANVSKASTLAAAEGSKVISAAIGSLREVGSILQSAASHIQQLEQASAKVDSVMDIINGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRSLAVRTVNAVSEISGTIETMKKESAEVILFMNQSEQTMEEGQSKGNQAMQALQRITQGTDE
AASQTERIFSSIKELSATSQAMAESMSQISSAMQALESYNTQLRVTSREVETRAESLEHDCRRFTL

Sequences:

>Translated_626_residues
MDVTQLSQKQKITLFILVLCLGFIGLAVFTAQSLSKMNSQYQQSGDVTAGSAALFATQAQLFELAAEREHLSSNKVSEIK
TRLAQLMQKVEGDKRFLAENNFANEGNALQQAVQAFNDDMQPWLEIKGELGFNVDDGKLAELKKLAVTIEKKIDETGMVT
INSDFQAMIKAQQNYLLQPNEQNLRLFNRALAGFVSMSQSYAMLDLYKAEIEQFKTTFLRVSELSQQVKDIEKNLLSSEA
TAQGVIESTAQRLEEVSSRYQSLAEKAGEQTLLSILVACVILAVLTVLLFMMVSFSLSKALTQIGRVLEKLSSGDLSQRL
ALISNKKDEFNQLAFAVNKSCENLGGLVHVVQDRSVALSGDAVALNQAIDNLVRGQSDVMDQTQRLASATEEVSLTTQQV
SHSLEVVANVSKASTLAAAEGSKVISAAIGSLREVGSILQSAASHIQQLEQASAKVDSVMDIINGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRSLAVRTVNAVSEISGTIETMKKESAEVILFMNQSEQTMEEGQSKGNQAMQALQRITQGTDE
AASQTERIFSSIKELSATSQAMAESMSQISSAMQALESYNTQLRVTSREVETRAESLEHDCRRFTL
>Mature_626_residues
MDVTQLSQKQKITLFILVLCLGFIGLAVFTAQSLSKMNSQYQQSGDVTAGSAALFATQAQLFELAAEREHLSSNKVSEIK
TRLAQLMQKVEGDKRFLAENNFANEGNALQQAVQAFNDDMQPWLEIKGELGFNVDDGKLAELKKLAVTIEKKIDETGMVT
INSDFQAMIKAQQNYLLQPNEQNLRLFNRALAGFVSMSQSYAMLDLYKAEIEQFKTTFLRVSELSQQVKDIEKNLLSSEA
TAQGVIESTAQRLEEVSSRYQSLAEKAGEQTLLSILVACVILAVLTVLLFMMVSFSLSKALTQIGRVLEKLSSGDLSQRL
ALISNKKDEFNQLAFAVNKSCENLGGLVHVVQDRSVALSGDAVALNQAIDNLVRGQSDVMDQTQRLASATEEVSLTTQQV
SHSLEVVANVSKASTLAAAEGSKVISAAIGSLREVGSILQSAASHIQQLEQASAKVDSVMDIINGIAEQTNLLALNAAIE
AARAGEQGRGFAVVADEVRSLAVRTVNAVSEISGTIETMKKESAEVILFMNQSEQTMEEGQSKGNQAMQALQRITQGTDE
AASQTERIFSSIKELSATSQAMAESMSQISSAMQALESYNTQLRVTSREVETRAESLEHDCRRFTL

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=386, Percent_Identity=30.0518134715026, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI2367378, Length=249, Percent_Identity=32.9317269076305, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1788195, Length=227, Percent_Identity=33.4801762114537, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788194, Length=313, Percent_Identity=28.7539936102236, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789453, Length=345, Percent_Identity=26.3768115942029, Blast_Score=90, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 68129; Mature: 68129

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVTQLSQKQKITLFILVLCLGFIGLAVFTAQSLSKMNSQYQQSGDVTAGSAALFATQAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LFELAAEREHLSSNKVSEIKTRLAQLMQKVEGDKRFLAENNFANEGNALQQAVQAFNDDM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHCCCC
QPWLEIKGELGFNVDDGKLAELKKLAVTIEKKIDETGMVTINSDFQAMIKAQQNYLLQPN
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCC
EQNLRLFNRALAGFVSMSQSYAMLDLYKAEIEQFKTTFLRVSELSQQVKDIEKNLLSSEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAQGVIESTAQRLEEVSSRYQSLAEKAGEQTLLSILVACVILAVLTVLLFMMVSFSLSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQIGRVLEKLSSGDLSQRLALISNKKDEFNQLAFAVNKSCENLGGLVHVVQDRSVALSG
HHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEHHCCCCEEECC
DAVALNQAIDNLVRGQSDVMDQTQRLASATEEVSLTTQQVSHSLEVVANVSKASTLAAAE
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSKVISAAIGSLREVGSILQSAASHIQQLEQASAKVDSVMDIINGIAEQTNLLALNAAIE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARAGEQGRGFAVVADEVRSLAVRTVNAVSEISGTIETMKKESAEVILFMNQSEQTMEEG
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
QSKGNQAMQALQRITQGTDEAASQTERIFSSIKELSATSQAMAESMSQISSAMQALESYN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TQLRVTSREVETRAESLEHDCRRFTL
CEEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVTQLSQKQKITLFILVLCLGFIGLAVFTAQSLSKMNSQYQQSGDVTAGSAALFATQAQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
LFELAAEREHLSSNKVSEIKTRLAQLMQKVEGDKRFLAENNFANEGNALQQAVQAFNDDM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHCCCC
QPWLEIKGELGFNVDDGKLAELKKLAVTIEKKIDETGMVTINSDFQAMIKAQQNYLLQPN
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCC
EQNLRLFNRALAGFVSMSQSYAMLDLYKAEIEQFKTTFLRVSELSQQVKDIEKNLLSSEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAQGVIESTAQRLEEVSSRYQSLAEKAGEQTLLSILVACVILAVLTVLLFMMVSFSLSKA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTQIGRVLEKLSSGDLSQRLALISNKKDEFNQLAFAVNKSCENLGGLVHVVQDRSVALSG
HHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEHHCCCCEEECC
DAVALNQAIDNLVRGQSDVMDQTQRLASATEEVSLTTQQVSHSLEVVANVSKASTLAAAE
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GSKVISAAIGSLREVGSILQSAASHIQQLEQASAKVDSVMDIINGIAEQTNLLALNAAIE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARAGEQGRGFAVVADEVRSLAVRTVNAVSEISGTIETMKKESAEVILFMNQSEQTMEEG
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
QSKGNQAMQALQRITQGTDEAASQTERIFSSIKELSATSQAMAESMSQISSAMQALESYN
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TQLRVTSREVETRAESLEHDCRRFTL
CEEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]