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The map label for this gene is hisQ [H]

Identifier: 227081991

GI number: 227081991

Start: 1938203

End: 1938985

Strand: Reverse

Name: hisQ [H]

Synonym: VCM66_1785

Alternate gene names: 227081991

Gene position: 1938985-1938203 (Counterclockwise)

Preceding gene: 227081992

Following gene: 227081990

Centisome position: 67.03

GC content: 48.53

Gene sequence:

>783_bases
ATGTCACCAACAACCCGTAATCCAACTCAGGGAACGAGTCATATGCTGGATTTACAAGGCTATGAAGCCTCTATTCTGAA
AGGCGCGCTGCTGACTATTGAAGTTGCCGTGCTGTCACTTTTGCTAGCGATGCTGCTAGGCATGTTAGGCGCACTCGCTA
AAATGGCACCCTACCGCTGGGCTCGAGCCATTGCGACACTCTATACCACCATCATTCGCGGTATTCCGGATTTAGTACTC
ATGATGCTGATTTTCTTTGGTGGGCAGATTTTACTCAACAATGGTCTCAGTTGGTTTAATGAGTTCATCAACCAATGGCT
GACAGCCCGAGATCCGAATCATGAATGGGTAGCCTATCTGCCCGATTATGTAGATATCAGCCCTTTTGTCGCGGGCGTGT
TAACCATCGGCTTCATTTTTGGGGCTTATATGGCGGAAACGTTTCGTGGCGCGATCCTTGCCGTGGATAAAGGTGAACTC
GAGGCGGCGAAAGCTTACGGCATGAGTGCTGCCATGAGCTTTCGGCGAATTTTATTACCGCAGATGATTCGCCATGCTAT
TCCTGGTTTTGGCAATAACTGGCTGGTGCTGCTGAAAACGACCGCTCTTGTCTCAATCATCGGCCTTGAAGATATGGTAC
GCATCAGTTCACTGGCGGCTGGCTCGACCAAGATGCCGTTTACCTTTTATATGGCGGTGGCCATCATCTTTCTATTTTTT
ACCAGTGTGTCGACCGGTTTGCTCAAGCTGCTAGAACGTAAATTCAGTATTCATACGAGGTAA

Upstream 100 bases:

>100_bases
CTTCTTATCACTTCGAGTTGCCGTCCACAGGACGGTAGCTTGAAATCATGGATTCGCGATTAAAGCTCACTGTATTTCGG
GTTGTTGGCACTCGTTCCTG

Downstream 100 bases:

>100_bases
AGATGGACTTTTCTCTGATTATCGACAGTTTGCCTATTTACCTAAGTGGACTTTGGACCACTGTCTGGCTAGTGAGCCTT
TCACTCGTAATCGGCTTGCT

Product: amino acid ABC transporter, permease protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSPTTRNPTQGTSHMLDLQGYEASILKGALLTIEVAVLSLLLAMLLGMLGALAKMAPYRWARAIATLYTTIIRGIPDLVL
MMLIFFGGQILLNNGLSWFNEFINQWLTARDPNHEWVAYLPDYVDISPFVAGVLTIGFIFGAYMAETFRGAILAVDKGEL
EAAKAYGMSAAMSFRRILLPQMIRHAIPGFGNNWLVLLKTTALVSIIGLEDMVRISSLAAGSTKMPFTFYMAVAIIFLFF
TSVSTGLLKLLERKFSIHTR

Sequences:

>Translated_260_residues
MSPTTRNPTQGTSHMLDLQGYEASILKGALLTIEVAVLSLLLAMLLGMLGALAKMAPYRWARAIATLYTTIIRGIPDLVL
MMLIFFGGQILLNNGLSWFNEFINQWLTARDPNHEWVAYLPDYVDISPFVAGVLTIGFIFGAYMAETFRGAILAVDKGEL
EAAKAYGMSAAMSFRRILLPQMIRHAIPGFGNNWLVLLKTTALVSIIGLEDMVRISSLAAGSTKMPFTFYMAVAIIFLFF
TSVSTGLLKLLERKFSIHTR
>Mature_259_residues
SPTTRNPTQGTSHMLDLQGYEASILKGALLTIEVAVLSLLLAMLLGMLGALAKMAPYRWARAIATLYTTIIRGIPDLVLM
MLIFFGGQILLNNGLSWFNEFINQWLTARDPNHEWVAYLPDYVDISPFVAGVLTIGFIFGAYMAETFRGAILAVDKGELE
AAKAYGMSAAMSFRRILLPQMIRHAIPGFGNNWLVLLKTTALVSIIGLEDMVRISSLAAGSTKMPFTFYMAVAIIFLFFT
SVSTGLLKLLERKFSIHTR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=243, Percent_Identity=46.5020576131687, Blast_Score=220, Evalue=7e-59,
Organism=Escherichia coli, GI1787087, Length=236, Percent_Identity=35.1694915254237, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1788226, Length=237, Percent_Identity=27.4261603375527, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787030, Length=233, Percent_Identity=29.1845493562232, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788645, Length=235, Percent_Identity=27.2340425531915, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786874, Length=235, Percent_Identity=25.1063829787234, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI87082239, Length=242, Percent_Identity=23.1404958677686, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787086, Length=238, Percent_Identity=25.6302521008403, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 28723; Mature: 28591

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPTTRNPTQGTSHMLDLQGYEASILKGALLTIEVAVLSLLLAMLLGMLGALAKMAPYRW
CCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARAIATLYTTIIRGIPDLVLMMLIFFGGQILLNNGLSWFNEFINQWLTARDPNHEWVAYL
HHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEC
PDYVDISPFVAGVLTIGFIFGAYMAETFRGAILAVDKGELEAAKAYGMSAAMSFRRILLP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
QMIRHAIPGFGNNWLVLLKTTALVSIIGLEDMVRISSLAAGSTKMPFTFYMAVAIIFLFF
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TSVSTGLLKLLERKFSIHTR
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPTTRNPTQGTSHMLDLQGYEASILKGALLTIEVAVLSLLLAMLLGMLGALAKMAPYRW
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARAIATLYTTIIRGIPDLVLMMLIFFGGQILLNNGLSWFNEFINQWLTARDPNHEWVAYL
HHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEC
PDYVDISPFVAGVLTIGFIFGAYMAETFRGAILAVDKGELEAAKAYGMSAAMSFRRILLP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
QMIRHAIPGFGNNWLVLLKTTALVSIIGLEDMVRISSLAAGSTKMPFTFYMAVAIIFLFF
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
TSVSTGLLKLLERKFSIHTR
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]