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The map label for this gene is irlR [H]

Identifier: 227081790

GI number: 227081790

Start: 1711409

End: 1712068

Strand: Direct

Name: irlR [H]

Synonym: VCM66_1577

Alternate gene names: 227081790

Gene position: 1711409-1712068 (Clockwise)

Preceding gene: 227081789

Following gene: 227081791

Centisome position: 59.17

GC content: 49.09

Gene sequence:

>660_bases
ATGAAAATATTAGTTGTTGAAGATGATGTTCAGTTAGGCCAGCAGATCCTCTCGGCATTAGAGCAAACAGGTTGGGTTCC
CGAATTGGCACAAGATGGCATCGATGCCTTATACCGCGCCACCGCGGAAGAGTGGGACGTCATCGTACTCGATCTCGGCC
TACCGAAATTGGATGGTTTGACCGTACTTAAAGGCATTCGAGACGAAAACATCAACACTCCTGTGGTGATTTTGAGTGCA
CGCGACACCCTCACTCAACGGGTCGAAGGTTTGAATGCAGGAGCGGACGATTACCTCACCAAACCCTTTGAAATGGTTGA
GTTGATTGCTCGTATTCGCGCCCAACTGCGCCGTGCGTCCGGCAATGCCTCCCCAGTGATGCAAGTCGGTGACCTGAGTT
TAGATACGCGCACTTCCAAAGTAATGTGGCAAGGGCAAGCGGTTAGCCTCACCGCCCTCGAATATAAAGTGATCGCCTAT
TTCATGCATAACCCTGAGAAAGTGATTTCACGCACTGAGCTTGTCGAACATATCTATAAGCAAGATTTTGACCGCGATTC
CAATACCATTGAGGTGTTCATCGGACGCATTCGTAAGAAAATTGCGCCGGATGTGATCAAAACTGTGCGCGGTCTTGGGT
ATCAGTTGCATGCCAATTAA

Upstream 100 bases:

>100_bases
ATCAAGTCTTTCGTGTCGAATACAACGCCGCTACGTTGGAGCTGATGTCCATTCGCGGGCGTAATGTGATTCGTGCCATC
AAAAAATAATCGAGCAGACC

Downstream 100 bases:

>100_bases
ATCTCGGGCGTTACGTCATCTCAGCCTAAAAACCCGCTTGCTCCTTGCTGCGGCACTATGGCTGGGCGCGATGATCTTGG
CCGCCGGCTATTTGATCCCA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKILVVEDDVQLGQQILSALEQTGWVPELAQDGIDALYRATAEEWDVIVLDLGLPKLDGLTVLKGIRDENINTPVVILSA
RDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGNASPVMQVGDLSLDTRTSKVMWQGQAVSLTALEYKVIAY
FMHNPEKVISRTELVEHIYKQDFDRDSNTIEVFIGRIRKKIAPDVIKTVRGLGYQLHAN

Sequences:

>Translated_219_residues
MKILVVEDDVQLGQQILSALEQTGWVPELAQDGIDALYRATAEEWDVIVLDLGLPKLDGLTVLKGIRDENINTPVVILSA
RDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGNASPVMQVGDLSLDTRTSKVMWQGQAVSLTALEYKVIAY
FMHNPEKVISRTELVEHIYKQDFDRDSNTIEVFIGRIRKKIAPDVIKTVRGLGYQLHAN
>Mature_219_residues
MKILVVEDDVQLGQQILSALEQTGWVPELAQDGIDALYRATAEEWDVIVLDLGLPKLDGLTVLKGIRDENINTPVVILSA
RDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGNASPVMQVGDLSLDTRTSKVMWQGQAVSLTALEYKVIAY
FMHNPEKVISRTELVEHIYKQDFDRDSNTIEVFIGRIRKKIAPDVIKTVRGLGYQLHAN

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=36.4864864864865, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=38.6363636363636, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=41.5525114155251, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=36.036036036036, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=37.1559633027523, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=38.1165919282511, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=31.390134529148, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=32.4444444444444, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=31.8385650224215, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.920704845815, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=28.936170212766, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=28.8888888888889, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=24.8908296943231, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790299, Length=146, Percent_Identity=28.0821917808219, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=32.6732673267327, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24529; Mature: 24529

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDDVQLGQQILSALEQTGWVPELAQDGIDALYRATAEEWDVIVLDLGLPKLDGL
CEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCH
TVLKGIRDENINTPVVILSARDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRAS
HHHHCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GNASPVMQVGDLSLDTRTSKVMWQGQAVSLTALEYKVIAYFMHNPEKVISRTELVEHIYK
CCCCCCEEECCCCCCCCCHHEEECCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFIGRIRKKIAPDVIKTVRGLGYQLHAN
HCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCEEEECC
>Mature Secondary Structure
MKILVVEDDVQLGQQILSALEQTGWVPELAQDGIDALYRATAEEWDVIVLDLGLPKLDGL
CEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCH
TVLKGIRDENINTPVVILSARDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRAS
HHHHCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GNASPVMQVGDLSLDTRTSKVMWQGQAVSLTALEYKVIAYFMHNPEKVISRTELVEHIYK
CCCCCCEEECCCCCCCCCHHEEECCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFIGRIRKKIAPDVIKTVRGLGYQLHAN
HCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]