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The map label for this gene is moeA-1 [H]

Identifier: 227081685

GI number: 227081685

Start: 1589090

End: 1590910

Strand: Direct

Name: moeA-1 [H]

Synonym: VCM66_1469

Alternate gene names: 227081685

Gene position: 1589090-1590910 (Clockwise)

Preceding gene: 227081684

Following gene: 227081687

Centisome position: 54.94

GC content: 50.36

Gene sequence:

>1821_bases
ATGATTGCTTCTGCACACCAGAATCCTCAACGCCCTAACCTGCCACTACTCGGTTTCGCTGCCTATTCTGGCACCGGAAA
AACGACGCTGCTAGAAGCCCTGCTGCCTAAACTGACAGCAACTGGTTTGCGCATTGGTCTGCTGAAACACGCGCACCACG
ATTTTGATGTCGATAAGCCAGGCAAAGACAGTTATCGCTTACGTAAAGCGGGAGCGTCTCAAATGCTGATTGCGTCGCGT
AACCGTCATGCGCTAATGACCGAAACCCCCGATGCCGAAGCGGAGTTTGATTATCTGTTGACTCGATTTGATGCTGAAAA
GCTCGATGTGATTTTGGTTGAAGGCTGTAAAAATATCGCTTTTCCAAAAATTGAACTGCACCGCGCGGAAGTCGGTAAGC
CTTGGCTTTACCCTCATGATAAAAACATCATTGCGATTGCTGCCGATGAGACGGTCGCAACGGATCTGCCGCAAATGCAC
ATTAATGATCTCGATGCGATCGCTGATTTCGTTTTGGATTATGTCAATAAGTGGCGCGCGCAGCAGATTCAACCACACAC
AGTGTCAGATTCCAAAAACAATGCAGCGGCATGCTGCGACACTTTATCCCCTGCTTTCCTTTCTGTAGAACAAGGCCGCG
AGAAGATCCTCTCGCTCATCTCACCTTTGGCAGAGACAGAATCGGTAGCGATTCAAGAGTGCTATCAACGCGTACTGGCG
CGTGAAGTTTTCTCTCCGAACAATGTGCCCGCCTATCGCAACTCAGCGATGGATGGCTATGCGCTGCGCAGTGATGATCT
TGAACGCGATAGCTACCGTGTAGTGGCGGAAGTGCTCGCCGGTAGTCATTATCCGAAAACGGTTGAACGCGGCGAAGCGG
TGAAGATTATGACTGGCGCACCAATGCCACTCGGTGCTGATACGGTAGTAATGCGTGAGCAAGCCACGCAAAACGGCGAA
CTGGTCAGTTTTGCGGGTGCCAAAATCAAAGCAGGACAAAACGTACGCCAAGCAGGTGAAGATTTGGCGCAAGGCCAAGC
GGTCTTTAGCATAGGTCAGCGTGTGCTTTCTCCAGAAATGGGCATGTTGGCGTCACTGGGTTTTGCGCACGCGGACGCAT
TTCGCTCGCTTAAAGTCGCGATTTTTTCGACAGGCGATGAAGTACAAGCGCCCGGCGGTGACATTGAGCCAAACTCTATT
TTTGATTCCAACCGTTTTACTCTGACAGGATTACTCAAACAGCTCGGCTGCCAAGTGATCGATCTCGGTATCATCGAAGA
TGACGAAGCAAAAATGATGCAAGTGCTTGAGCAAGCAGCAAAACAGGCTGATGTGGTGATCACTTCCGGTGGTGTTTCTG
TGGGCGATGCGGATTTCATCAAATCCGCGCTAGAGAAGCTGGGACAAATTGATTTTTGGCGGATCAATATGCGTCCGGGA
CGCCCACTGGCGTTTGGCCAGATTGCTGGAAAACCTTTCTTCGGTCTACCGGGCAACCCTGTCGCGGTAATGGTTTCTTT
CATCAACTTTGTGGAACCTGCTCTGCGTAAAATGCAAGGTGAACAAGGTTGGCAACCACTGAAAGTCAATGCGATTGCGT
TGGAAGATCTGCGCTCTCGCCAAGGCAGAACTGAGTTCAGCCGTGGGGTTTACGCTTTTAATACGCAAGGACAACTGACA
GTACGTACCACGGGCAAACAAGGTTCGGGGATTTTGCGCTCAATGAGTGAAGCGAACTGCTTGATTGAAATTGCTCCGGC
GATTGATACGGTAAAAGTCGGTGAAAGCGTGACAATCATCCCACTTCAAGGCAGAATCTAG

Upstream 100 bases:

>100_bases
ATGAATGCCATACTTCTTACGTCGATTTTAGCGATGCACCAAGCTGCTTTTTTAATTTGAATACGCCACAAGAGTTGGCG
CAATTTGGAGCGTTACATCC

Downstream 100 bases:

>100_bases
TGTGTTCACTCCCTATACTTGCTTCTCTTCATAGTATGACGTCAATATAGGGACTCTTTACCAAAAGCGGCAATCAAGAA
CATCCATCATCACTCAAGAT

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MIASAHQNPQRPNLPLLGFAAYSGTGKTTLLEALLPKLTATGLRIGLLKHAHHDFDVDKPGKDSYRLRKAGASQMLIASR
NRHALMTETPDAEAEFDYLLTRFDAEKLDVILVEGCKNIAFPKIELHRAEVGKPWLYPHDKNIIAIAADETVATDLPQMH
INDLDAIADFVLDYVNKWRAQQIQPHTVSDSKNNAAACCDTLSPAFLSVEQGREKILSLISPLAETESVAIQECYQRVLA
REVFSPNNVPAYRNSAMDGYALRSDDLERDSYRVVAEVLAGSHYPKTVERGEAVKIMTGAPMPLGADTVVMREQATQNGE
LVSFAGAKIKAGQNVRQAGEDLAQGQAVFSIGQRVLSPEMGMLASLGFAHADAFRSLKVAIFSTGDEVQAPGGDIEPNSI
FDSNRFTLTGLLKQLGCQVIDLGIIEDDEAKMMQVLEQAAKQADVVITSGGVSVGDADFIKSALEKLGQIDFWRINMRPG
RPLAFGQIAGKPFFGLPGNPVAVMVSFINFVEPALRKMQGEQGWQPLKVNAIALEDLRSRQGRTEFSRGVYAFNTQGQLT
VRTTGKQGSGILRSMSEANCLIEIAPAIDTVKVGESVTIIPLQGRI

Sequences:

>Translated_606_residues
MIASAHQNPQRPNLPLLGFAAYSGTGKTTLLEALLPKLTATGLRIGLLKHAHHDFDVDKPGKDSYRLRKAGASQMLIASR
NRHALMTETPDAEAEFDYLLTRFDAEKLDVILVEGCKNIAFPKIELHRAEVGKPWLYPHDKNIIAIAADETVATDLPQMH
INDLDAIADFVLDYVNKWRAQQIQPHTVSDSKNNAAACCDTLSPAFLSVEQGREKILSLISPLAETESVAIQECYQRVLA
REVFSPNNVPAYRNSAMDGYALRSDDLERDSYRVVAEVLAGSHYPKTVERGEAVKIMTGAPMPLGADTVVMREQATQNGE
LVSFAGAKIKAGQNVRQAGEDLAQGQAVFSIGQRVLSPEMGMLASLGFAHADAFRSLKVAIFSTGDEVQAPGGDIEPNSI
FDSNRFTLTGLLKQLGCQVIDLGIIEDDEAKMMQVLEQAAKQADVVITSGGVSVGDADFIKSALEKLGQIDFWRINMRPG
RPLAFGQIAGKPFFGLPGNPVAVMVSFINFVEPALRKMQGEQGWQPLKVNAIALEDLRSRQGRTEFSRGVYAFNTQGQLT
VRTTGKQGSGILRSMSEANCLIEIAPAIDTVKVGESVTIIPLQGRI
>Mature_606_residues
MIASAHQNPQRPNLPLLGFAAYSGTGKTTLLEALLPKLTATGLRIGLLKHAHHDFDVDKPGKDSYRLRKAGASQMLIASR
NRHALMTETPDAEAEFDYLLTRFDAEKLDVILVEGCKNIAFPKIELHRAEVGKPWLYPHDKNIIAIAADETVATDLPQMH
INDLDAIADFVLDYVNKWRAQQIQPHTVSDSKNNAAACCDTLSPAFLSVEQGREKILSLISPLAETESVAIQECYQRVLA
REVFSPNNVPAYRNSAMDGYALRSDDLERDSYRVVAEVLAGSHYPKTVERGEAVKIMTGAPMPLGADTVVMREQATQNGE
LVSFAGAKIKAGQNVRQAGEDLAQGQAVFSIGQRVLSPEMGMLASLGFAHADAFRSLKVAIFSTGDEVQAPGGDIEPNSI
FDSNRFTLTGLLKQLGCQVIDLGIIEDDEAKMMQVLEQAAKQADVVITSGGVSVGDADFIKSALEKLGQIDFWRINMRPG
RPLAFGQIAGKPFFGLPGNPVAVMVSFINFVEPALRKMQGEQGWQPLKVNAIALEDLRSRQGRTEFSRGVYAFNTQGQLT
VRTTGKQGSGILRSMSEANCLIEIAPAIDTVKVGESVTIIPLQGRI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=381, Percent_Identity=35.4330708661417, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI66932975, Length=381, Percent_Identity=35.4330708661417, Blast_Score=220, Evalue=4e-57,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=42.2976501305483, Blast_Score=317, Evalue=2e-87,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=53.6144578313253, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=371, Percent_Identity=31.8059299191375, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=361, Percent_Identity=26.0387811634349, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136978, Length=361, Percent_Identity=36.5650969529086, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24638841, Length=361, Percent_Identity=36.5650969529086, Blast_Score=173, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 65925; Mature: 65925

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASAHQNPQRPNLPLLGFAAYSGTGKTTLLEALLPKLTATGLRIGLLKHAHHDFDVDKP
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
GKDSYRLRKAGASQMLIASRNRHALMTETPDAEAEFDYLLTRFDAEKLDVILVEGCKNIA
CCCCHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHCCEEEEECCCCCC
FPKIELHRAEVGKPWLYPHDKNIIAIAADETVATDLPQMHINDLDAIADFVLDYVNKWRA
CCCEEEEHHHCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
QQIQPHTVSDSKNNAAACCDTLSPAFLSVEQGREKILSLISPLAETESVAIQECYQRVLA
HCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REVFSPNNVPAYRNSAMDGYALRSDDLERDSYRVVAEVLAGSHYPKTVERGEAVKIMTGA
HHHCCCCCCCCHHCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCHHCCCCEEEEEECC
PMPLGADTVVMREQATQNGELVSFAGAKIKAGQNVRQAGEDLAQGQAVFSIGQRVLSPEM
CCCCCCCEEEEEHHCCCCCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
GMLASLGFAHADAFRSLKVAIFSTGDEVQAPGGDIEPNSIFDSNRFTLTGLLKQLGCQVI
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCEEE
DLGIIEDDEAKMMQVLEQAAKQADVVITSGGVSVGDADFIKSALEKLGQIDFWRINMRPG
EEEEEECCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
RPLAFGQIAGKPFFGLPGNPVAVMVSFINFVEPALRKMQGEQGWQPLKVNAIALEDLRSR
CCEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
QGRTEFSRGVYAFNTQGQLTVRTTGKQGSGILRSMSEANCLIEIAPAIDTVKVGESVTII
CCCCHHHCCEEEECCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCEEECCCEEEEE
PLQGRI
ECCCCC
>Mature Secondary Structure
MIASAHQNPQRPNLPLLGFAAYSGTGKTTLLEALLPKLTATGLRIGLLKHAHHDFDVDKP
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCC
GKDSYRLRKAGASQMLIASRNRHALMTETPDAEAEFDYLLTRFDAEKLDVILVEGCKNIA
CCCCHHHHHCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHCCHHHCCEEEEECCCCCC
FPKIELHRAEVGKPWLYPHDKNIIAIAADETVATDLPQMHINDLDAIADFVLDYVNKWRA
CCCEEEEHHHCCCCCCCCCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
QQIQPHTVSDSKNNAAACCDTLSPAFLSVEQGREKILSLISPLAETESVAIQECYQRVLA
HCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REVFSPNNVPAYRNSAMDGYALRSDDLERDSYRVVAEVLAGSHYPKTVERGEAVKIMTGA
HHHCCCCCCCCHHCCCCCCCEECCCCCCCHHHHHHHHHHHCCCCCCHHCCCCEEEEEECC
PMPLGADTVVMREQATQNGELVSFAGAKIKAGQNVRQAGEDLAQGQAVFSIGQRVLSPEM
CCCCCCCEEEEEHHCCCCCCEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCH
GMLASLGFAHADAFRSLKVAIFSTGDEVQAPGGDIEPNSIFDSNRFTLTGLLKQLGCQVI
HHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCEEE
DLGIIEDDEAKMMQVLEQAAKQADVVITSGGVSVGDADFIKSALEKLGQIDFWRINMRPG
EEEEEECCHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCC
RPLAFGQIAGKPFFGLPGNPVAVMVSFINFVEPALRKMQGEQGWQPLKVNAIALEDLRSR
CCEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHH
QGRTEFSRGVYAFNTQGQLTVRTTGKQGSGILRSMSEANCLIEIAPAIDTVKVGESVTII
CCCCHHHCCEEEECCCCEEEEEECCCCCCHHHHHHHCCCEEEEECCCCCEEECCCEEEEE
PLQGRI
ECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]