Click here to switch to the map view.

The map label for this gene is fabA

Identifier: 227081642

GI number: 227081642

Start: 1536227

End: 1536745

Strand: Direct

Name: fabA

Synonym: VCM66_1426

Alternate gene names: 227081642

Gene position: 1536227-1536745 (Clockwise)

Preceding gene: 227081641

Following gene: 227081658

Centisome position: 53.11

GC content: 44.51

Gene sequence:

>519_bases
ATGCAGAACAAACGTGATTCGTATAATCGAGAAGATCTTTTAGCGTCAAGCCAAGGTGAGTTGTTTGGTGAGGGCTATCC
TCAACTTCCAGCGCCAAATATGTTGATGATGGATCGCATTACCAAGATGTCAGAAACTGAAGGTGAATTTGGTAAAGGTT
TGATCTTAGCTGAGCTCGATATCACGCCTGATTTATGGTTTTTTGATTGCCATTTCCCAGGAGACCCAGTGATGCCGGGA
TGCTTGGGCTTAGATGCCATGTGGCAACTGGTGGGTTTTTTCCTTGGCTGGGTTGGCGGTAAAGGTAAAGGTCGCGCGCT
TGGCGTTGGCGAAGTGAAATTTACAGGACAAATTTTACCAACAGCTAAAAAAGTCACCTACGAAATTAACATGAAGCGTG
TGGTGAACCGTAAGCTAGTGATGGGTTTAGCCGATGGTCGCGTACTTGTTGATGGCAAAGAAATATACGTAGCCAAAGAT
CTTAAAGTTGGCTTGTTCCAAGATACGTCTGCGTTTTAA

Upstream 100 bases:

>100_bases
GTGGAACGGATCAAAAACTGGCTTAGCTGGCACTGATCGGAGTTGTTTGGCGTACACGTGTTCACTAACATGCACCCAAC
AAAAAATGGAGTAACCAATA

Downstream 100 bases:

>100_bases
AGATAGAATCTCTAACGAATAACAGCCCGTTTCGGGCTGTTTTCCTAGCGATAAGCCTTTTCAAGCTTTGTTGTATGGGA
AATTATTTGCAGAGACCAGA

Product: 3-hydroxydecanoyl-(acyl carrier protein) dehydratase

Products: NA

Alternate protein names: Beta-hydroxydecanoyl thioester dehydrase

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELDITPDLWFFDCHFPGDPVMPG
CLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILPTAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKD
LKVGLFQDTSAF

Sequences:

>Translated_172_residues
MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELDITPDLWFFDCHFPGDPVMPG
CLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILPTAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKD
LKVGLFQDTSAF
>Mature_172_residues
MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELDITPDLWFFDCHFPGDPVMPG
CLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILPTAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKD
LKVGLFQDTSAF

Specific function: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzed the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP

COG id: COG0764

COG function: function code I; 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioester dehydratase family. FabA subfamily

Homologues:

Organism=Escherichia coli, GI1787187, Length=172, Percent_Identity=78.4883720930232, Blast_Score=283, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABA_VIBC3 (A5F850)

Other databases:

- EMBL:   CP000627
- EMBL:   CP001235
- ProteinModelPortal:   A5F850
- SMR:   A5F850
- STRING:   A5F850
- GenomeReviews:   CP000627_GR
- GenomeReviews:   CP001235_GR
- KEGG:   vco:VC0395_A1091
- eggNOG:   COG0764
- HOGENOM:   HBG433282
- OMA:   CHFKGDP
- ProtClustDB:   PRK05174
- BioCyc:   VCHO345073:VC0395_A1091-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00405
- InterPro:   IPR000794
- InterPro:   IPR010083
- InterPro:   IPR013114
- PANTHER:   PTHR11712
- TIGRFAMs:   TIGR01749

Pfam domain/function: PF07977 FabA

EC number: =4.2.1.60

Molecular weight: Translated: 19042; Mature: 19042

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELD
CCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEC
ITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILP
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEECEECC
TAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKDLKVGLFQDTSAF
CCEEEEEEECHHHHHCHHEEEEECCCEEEEECCEEEEEECCEEEEECCCCCC
>Mature Secondary Structure
MQNKRDSYNREDLLASSQGELFGEGYPQLPAPNMLMMDRITKMSETEGEFGKGLILAELD
CCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEC
ITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLGWVGGKGKGRALGVGEVKFTGQILP
CCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCEEEECEECC
TAKKVTYEINMKRVVNRKLVMGLADGRVLVDGKEIYVAKDLKVGLFQDTSAF
CCEEEEEEECHHHHHCHHEEEEECCCEEEEECCEEEEEECCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA