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The map label for this gene is vceA [H]

Identifier: 227081581

GI number: 227081581

Start: 1460504

End: 1461724

Strand: Direct

Name: vceA [H]

Synonym: VCM66_1365

Alternate gene names: 227081581

Gene position: 1460504-1461724 (Clockwise)

Preceding gene: 227081580

Following gene: 227081582

Centisome position: 50.49

GC content: 49.71

Gene sequence:

>1221_bases
TTGAAACAACAGAATCTTAATAGGTTATCTTCAATGAATTCAAATAATAGCAACACCGAATTTGATGGTGTACGCGCAGC
TCAATCGCGTAAAAAAGGGTTTCTCGGATTAGCGGCCGCAATTGTGGTTGCCGGGGGGAGTTATGCACTCTATTGGCACT
TTATCGGTTCACGCTACATTTCCACCGACAACGCTTATGCTGCGGCGGAAATCGCCGAAGTCACGCCGGCCGTGGGCGGG
ATTATCGCGCAAGTGAATGTAGTGGATACCGAGTACGTCAAACAAGGCGACGTACTTGTACAGCTGGATGATACCGATGC
GAGATTAGCTTTGCTTCAAGCTGAGGCGGATTTGGCACTCGCAAAACGCCGTGTACGTAGCTATCTCGCTAATGACGAAG
GTTTAAGTGCTATGGTGGAAGCACAAGAAGCCAATGAGCAGCGTGTGAAAGCGCAGTTAAAAGCGGCGCAAGCGGACTTT
GAACGAGCAAAAATCGATTTATCTCGTCGGGAAGACTTAGTGCGTTCCGGCTCCGTTTCTGGTGAAGAGCTGACGAATGC
CAAAACCGGTTTTGCGCAGGCACAAGCAAACCTTAATGCGGCAAAAGCGGCTATGGCGCAAGCACAGGCAACTAAGCTCT
CGACTATTGGCTCACAAAAAGCTAATGCAGCGTTGACCGATAACACGACCGTCGATAGCAACCCTGAAGTCTTACTGGCA
AAAGCGCGTTATGAACAAGCGAAAATCGATCTCGAGCGTACGGTGATTCGTGCGCCGATCAGTGGAATCGTCGCTAAACG
CCAAGTACAAGTTGGGCGTCGTGTACAGGTGGGGATGCCTTTAATGACCGTGGTGCCTACTGATCATATTTATGTCGATG
CCAATTTTAAAGAAGTGGAATTGCGCGATGTGAAAGTTGGACAACCCGTTACCTTAACGGCAGATCTGTATGGTGATGAT
GTGACCTACCATGGTGTGGTCGCTGGTTTTTCCGGCGGTACGGGCTCCGCATTTTCGATGATCCCTGCACAAAACGCCAC
AGGCAACTGGATTAAAGTGGTGCAGCGTTTGCCGATCCGTATCGAGTTGGACCCCAAAGATTTGCAAGCTTATCCACTGC
AGGTGGGATTATCTATGGTTGCCACGATAGATACTGCAGGAACTACCGATCCACAAACCTTAGTGCAGTACCGCGCCGCC
AAAGTTTCAGAGCAAGGCTAA

Upstream 100 bases:

>100_bases
GCTGAAGAGTCTTTACTCAATAACCAAAGAGCATTGGTCAATTTGCAGTCACGCGCTTTTAGTTTAGATCTTGCGCTGAT
CCATGCGCTAGGCGGCGGTT

Downstream 100 bases:

>100_bases
GGTGAATCCATGAGTCATAACGCTGACAATGAGATGCAACCTCTGTCAGGATGGGCACTGTTTTTCGGTGCCCTGTGTCT
GGCAATGGCCAACTTTCTCG

Product: multidrug resistance protein VceA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKQQNLNRLSSMNSNNSNTEFDGVRAAQSRKKGFLGLAAAIVVAGGSYALYWHFIGSRYISTDNAYAAAEIAEVTPAVGG
IIAQVNVVDTEYVKQGDVLVQLDDTDARLALLQAEADLALAKRRVRSYLANDEGLSAMVEAQEANEQRVKAQLKAAQADF
ERAKIDLSRREDLVRSGSVSGEELTNAKTGFAQAQANLNAAKAAMAQAQATKLSTIGSQKANAALTDNTTVDSNPEVLLA
KARYEQAKIDLERTVIRAPISGIVAKRQVQVGRRVQVGMPLMTVVPTDHIYVDANFKEVELRDVKVGQPVTLTADLYGDD
VTYHGVVAGFSGGTGSAFSMIPAQNATGNWIKVVQRLPIRIELDPKDLQAYPLQVGLSMVATIDTAGTTDPQTLVQYRAA
KVSEQG

Sequences:

>Translated_406_residues
MKQQNLNRLSSMNSNNSNTEFDGVRAAQSRKKGFLGLAAAIVVAGGSYALYWHFIGSRYISTDNAYAAAEIAEVTPAVGG
IIAQVNVVDTEYVKQGDVLVQLDDTDARLALLQAEADLALAKRRVRSYLANDEGLSAMVEAQEANEQRVKAQLKAAQADF
ERAKIDLSRREDLVRSGSVSGEELTNAKTGFAQAQANLNAAKAAMAQAQATKLSTIGSQKANAALTDNTTVDSNPEVLLA
KARYEQAKIDLERTVIRAPISGIVAKRQVQVGRRVQVGMPLMTVVPTDHIYVDANFKEVELRDVKVGQPVTLTADLYGDD
VTYHGVVAGFSGGTGSAFSMIPAQNATGNWIKVVQRLPIRIELDPKDLQAYPLQVGLSMVATIDTAGTTDPQTLVQYRAA
KVSEQG
>Mature_406_residues
MKQQNLNRLSSMNSNNSNTEFDGVRAAQSRKKGFLGLAAAIVVAGGSYALYWHFIGSRYISTDNAYAAAEIAEVTPAVGG
IIAQVNVVDTEYVKQGDVLVQLDDTDARLALLQAEADLALAKRRVRSYLANDEGLSAMVEAQEANEQRVKAQLKAAQADF
ERAKIDLSRREDLVRSGSVSGEELTNAKTGFAQAQANLNAAKAAMAQAQATKLSTIGSQKANAALTDNTTVDSNPEVLLA
KARYEQAKIDLERTVIRAPISGIVAKRQVQVGRRVQVGMPLMTVVPTDHIYVDANFKEVELRDVKVGQPVTLTADLYGDD
VTYHGVVAGFSGGTGSAFSMIPAQNATGNWIKVVQRLPIRIELDPKDLQAYPLQVGLSMVATIDTAGTTDPQTLVQYRAA
KVSEQG

Specific function: Unknown

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=367, Percent_Identity=40.3269754768392, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1789041, Length=375, Percent_Identity=39.2, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1790519, Length=334, Percent_Identity=30.8383233532934, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87081951, Length=344, Percent_Identity=25.8720930232558, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789637, Length=148, Percent_Identity=30.4054054054054, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43598; Mature: 43598

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQQNLNRLSSMNSNNSNTEFDGVRAAQSRKKGFLGLAAAIVVAGGSYALYWHFIGSRYI
CCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHEEHHHEECCCEEEEEEEECCEEE
STDNAYAAAEIAEVTPAVGGIIAQVNVVDTEYVKQGDVLVQLDDTDARLALLQAEADLAL
ECCCCHHHHHHHHHHHHHCCEEEEEEEECHHHHCCCCEEEEECCCCCEEEEEECHHHHHH
AKRRVRSYLANDEGLSAMVEAQEANEQRVKAQLKAAQADFERAKIDLSRREDLVRSGSVS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
GEELTNAKTGFAQAQANLNAAKAAMAQAQATKLSTIGSQKANAALTDNTTVDSNPEVLLA
CHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEE
KARYEQAKIDLERTVIRAPISGIVAKRQVQVGRRVQVGMPLMTVVPTDHIYVDANFKEVE
ECHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCEEEEECCCEEEEECCCCEEE
LRDVKVGQPVTLTADLYGDDVTYHGVVAGFSGGTGSAFSMIPAQNATGNWIKVVQRLPIR
EEEEECCCCEEEEEECCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCE
IELDPKDLQAYPLQVGLSMVATIDTAGTTDPQTLVQYRAAKVSEQG
EEECHHCCCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKQQNLNRLSSMNSNNSNTEFDGVRAAQSRKKGFLGLAAAIVVAGGSYALYWHFIGSRYI
CCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHEEHHHEECCCEEEEEEEECCEEE
STDNAYAAAEIAEVTPAVGGIIAQVNVVDTEYVKQGDVLVQLDDTDARLALLQAEADLAL
ECCCCHHHHHHHHHHHHHCCEEEEEEEECHHHHCCCCEEEEECCCCCEEEEEECHHHHHH
AKRRVRSYLANDEGLSAMVEAQEANEQRVKAQLKAAQADFERAKIDLSRREDLVRSGSVS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
GEELTNAKTGFAQAQANLNAAKAAMAQAQATKLSTIGSQKANAALTDNTTVDSNPEVLLA
CHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEE
KARYEQAKIDLERTVIRAPISGIVAKRQVQVGRRVQVGMPLMTVVPTDHIYVDANFKEVE
ECHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCEEEEECCCEEEEECCCCEEE
LRDVKVGQPVTLTADLYGDDVTYHGVVAGFSGGTGSAFSMIPAQNATGNWIKVVQRLPIR
EEEEECCCCEEEEEECCCCCEEEEEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHCCCE
IELDPKDLQAYPLQVGLSMVATIDTAGTTDPQTLVQYRAAKVSEQG
EEECHHCCCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]