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The map label for this gene is tpm [H]

Identifier: 227081398

GI number: 227081398

Start: 1259388

End: 1260044

Strand: Direct

Name: tpm [H]

Synonym: VCM66_1181

Alternate gene names: 227081398

Gene position: 1259388-1260044 (Clockwise)

Preceding gene: 227081397

Following gene: 227081402

Centisome position: 43.54

GC content: 49.62

Gene sequence:

>657_bases
ATGCGAGATCCTGAGTTTTGGCATAACAAATGGGCGGCGAACCAGATTGGTTTTCACCTTGAAGACGTGAACCCGCTATT
GATCCGCTTTTGGTCTGATCTTGCCCCTAAACGCAGTGAAAAAGTGCTCGTCCCTTTGTGTGGTAAGAGTGAAGATCTGA
TTTGGCTGGCGAATCAGCATGACAGTGTTCAAGGGGTTGAACTGAGTCAAATCGCGGTACGTTCTTTCTTTGCCGAGCAT
TTCTATACCCCGACAGTGACCCGACTCAATGCGCAACATGAGCTGTATCAGTTTGATGAGCTTACGCTTTTTACCGGCGA
TTTCTTCACAGCTCCTGTTGAATCGGTGGACTTAGTTTATGATCGTGCAGCGCTAGTGGCATTGCCGGAAGAGATGCGCG
CAGAGTACGCGCAGCGCGTGTTGCAACTGCTTAAACCGGGTGGGCGCATTTTGCTGGTCAGTATGGATTATGTGCAAACT
GAGTTGTCAGGGCCGCCATTTTCGGTTCCTGAAGCGGAAATTCGCACCTTGTTTATGGGATGTGAGGTGCGCAGAGTTTA
CCAAGATACGAGCATAGATCCGCATCTGAATAAGCGCACACAAGCGGGCTTAAGCCGCTTTGCCGAAGAAGTTTGGGTGA
TTGAGAAAAGCGAGTGA

Upstream 100 bases:

>100_bases
GAAATGTAACCGTCGAACAGATGGGGAGGGACAAATTCGTGCTACCGCGGGAGCAGAAGATCCGCTACTCTTGGCGGCAG
CAAGTGAAAAGGAGTAGAAG

Downstream 100 bases:

>100_bases
CTCTGACTCTTTGAACGCCACTAAGTAGAAATGAAAAAAGCGCGCTGAAAGAGCGCGCTTTCTGATAGTGCTGATGAAGA
TAAAGAGCTGAATTAGTAAT

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH
FYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVYDRAALVALPEEMRAEYAQRVLQLLKPGGRILLVSMDYVQT
ELSGPPFSVPEAEIRTLFMGCEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE

Sequences:

>Translated_218_residues
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH
FYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVYDRAALVALPEEMRAEYAQRVLQLLKPGGRILLVSMDYVQT
ELSGPPFSVPEAEIRTLFMGCEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE
>Mature_218_residues
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQHDSVQGVELSQIAVRSFFAEH
FYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVYDRAALVALPEEMRAEYAQRVLQLLKPGGRILLVSMDYVQT
ELSGPPFSVPEAEIRTLFMGCEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

Organism=Homo sapiens, GI4507653, Length=189, Percent_Identity=32.2751322751323, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 25114; Mature: 25114

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQH
CCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCC
DSVQGVELSQIAVRSFFAEHFYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVY
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHEECCCEEEEECCCCCCCHHHHHHHH
DRAALVALPEEMRAEYAQRVLQLLKPGGRILLVSMDYVQTELSGPPFSVPEAEIRTLFMG
HHHHEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCCHHHHHHHHHC
CEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCC
>Mature Secondary Structure
MRDPEFWHNKWAANQIGFHLEDVNPLLIRFWSDLAPKRSEKVLVPLCGKSEDLIWLANQH
CCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEECCC
DSVQGVELSQIAVRSFFAEHFYTPTVTRLNAQHELYQFDELTLFTGDFFTAPVESVDLVY
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCHHHHEECCCEEEEECCCCCCCHHHHHHHH
DRAALVALPEEMRAEYAQRVLQLLKPGGRILLVSMDYVQTELSGPPFSVPEAEIRTLFMG
HHHHEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHCCCCCCCCCHHHHHHHHHC
CEVRRVYQDTSIDPHLNKRTQAGLSRFAEEVWVIEKSE
CHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA