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The map label for this gene is gltP-1 [H]

Identifier: 227081340

GI number: 227081340

Start: 1198115

End: 1199491

Strand: Reverse

Name: gltP-1 [H]

Synonym: VCM66_1123

Alternate gene names: 227081340

Gene position: 1199491-1198115 (Counterclockwise)

Preceding gene: 227081341

Following gene: 227081337

Centisome position: 41.47

GC content: 48.37

Gene sequence:

>1377_bases
ATGTGCTTATTGCTAAATGTAAACATTCCGTGTAAAAAGCAGGAGCAAAATTTTTGCCCATTTAGTGATATGACACTAGT
GGCTAACACTAGGAATTTACAATTTATTAGCACAGAGGTTATGGAAGTGTTAAAGACAAAGGGTTTACTAAACAACATCG
GCGTGCAAGTGGTGATCGCCATGCTCGCGGGTACCGCAGTCGGTGCAGCAATGGGTCACGATGCGACACTATTTGCTCCA
CTGGGTGCGATTTTTATTAATCTGATCAAAATGCTGGTGATTCCTCTGGTGGCTGTGGCACTGATTTCTGGTGCAGCAGG
TCTGGGTGATAGCCATTCTGCTGGCAAGGTCGGTGCAGTGACGTTAAGTTACTTTGCTATTACCTCTGCCGCCGCCGTAG
CTCTGGCATTGATCATGGGTGAACTGTTCCAACCGGGTGTCGGAGTCGATGTTTCTGGTGTAGAGAGCATGTTCTCTTCT
GAATACGCTGCGCAAGGTGAGCTCCCCACTTTCTGGGCAACCATCATTGGTATGATCCCAACCAACGTTTTCCAGTCACT
GAACGAAGCGAACATTCTACAGATCTTGGTTTTCTGTCTGTTTTTAGGCATTGCGATTTCTAAGCAAGCCAAAGAAAAAC
GTGACCCAGTGATCAACGCGGTGAACACCATTGTTGATGCCATGGTGTGGATGATCAATAAAGTGATGCTGATTGCGCCG
ATTGGTGTATTTGGCTTAATGGCTGATGCCGTGGGTACTTTTGGTTTCAGCGCGCTGATGGTGGTGTTTAAGCTGTTCGT
CGTTTACGTAGCGGCGATTGCGATTTTTGGCTTTGTGGCTTACCCAGTCATGATCCAACTGTTCAGCAAAACATCGGCGA
AAAAGTTCATTCAAGCAATGAAAAAGCCACAAGCGGTTGCACTGTCTACGGCCTCTTCTATGGCGACACTGCCTGTCACT
ATGGATACGGTGAAAAACGATCTGGGTGTGCGCAACTCAACGGCTTCTTTCGTACTGCCTTTGGGCGCGACCATCAATAT
GTCAGGTAACGCGATCTACTACGGTCTGGTGGCTATCTTCTTTGCTCAGCTGTTTAATATTGACCTGAGCATGGGCGCTT
ACATTGCGATCATCGTGACGGCGACTTTAGGTGCGGTTGGTCAAGCGGGTGTTCCGGGGCCTTCATTCCTTGTGGTGGCG
GTTCTGCTCTCTGCCGGTATTCCTATTGAAGGTCTACCACTGCTGTTTGCACTGGATCGTATCTTTGACATGATCCGTAC
TGCGCTCAACATTACCGGCGATGCGGCTTGTGCAGTGATTGTGGATTCGATGATCACTGAGGAAGCGGCGGCTGAGCTGG
AAAAACGTGAAGCTTAA

Upstream 100 bases:

>100_bases
ATTCAAGACTTCATATAACCAAAATCAATAGCAAACGTTTTCTTTGCAGATAAAAACGCCAAATTACTCTCGTTTTACTC
CGCTATTGAGAAAACGCTCG

Downstream 100 bases:

>100_bases
TCGCTGATCATTATCATTCATAAAAAAAGCCAGACATTAACTGTCTGGCTTTTTCTTTATTGAGTCACGGGCAAATTATC
CCGCGAAGGAGATGGGTTCG

Product: proton/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MCLLLNVNIPCKKQEQNFCPFSDMTLVANTRNLQFISTEVMEVLKTKGLLNNIGVQVVIAMLAGTAVGAAMGHDATLFAP
LGAIFINLIKMLVIPLVAVALISGAAGLGDSHSAGKVGAVTLSYFAITSAAAVALALIMGELFQPGVGVDVSGVESMFSS
EYAAQGELPTFWATIIGMIPTNVFQSLNEANILQILVFCLFLGIAISKQAKEKRDPVINAVNTIVDAMVWMINKVMLIAP
IGVFGLMADAVGTFGFSALMVVFKLFVVYVAAIAIFGFVAYPVMIQLFSKTSAKKFIQAMKKPQAVALSTASSMATLPVT
MDTVKNDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYIAIIVTATLGAVGQAGVPGPSFLVVA
VLLSAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVDSMITEEAAAELEKREA

Sequences:

>Translated_458_residues
MCLLLNVNIPCKKQEQNFCPFSDMTLVANTRNLQFISTEVMEVLKTKGLLNNIGVQVVIAMLAGTAVGAAMGHDATLFAP
LGAIFINLIKMLVIPLVAVALISGAAGLGDSHSAGKVGAVTLSYFAITSAAAVALALIMGELFQPGVGVDVSGVESMFSS
EYAAQGELPTFWATIIGMIPTNVFQSLNEANILQILVFCLFLGIAISKQAKEKRDPVINAVNTIVDAMVWMINKVMLIAP
IGVFGLMADAVGTFGFSALMVVFKLFVVYVAAIAIFGFVAYPVMIQLFSKTSAKKFIQAMKKPQAVALSTASSMATLPVT
MDTVKNDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYIAIIVTATLGAVGQAGVPGPSFLVVA
VLLSAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVDSMITEEAAAELEKREA
>Mature_458_residues
MCLLLNVNIPCKKQEQNFCPFSDMTLVANTRNLQFISTEVMEVLKTKGLLNNIGVQVVIAMLAGTAVGAAMGHDATLFAP
LGAIFINLIKMLVIPLVAVALISGAAGLGDSHSAGKVGAVTLSYFAITSAAAVALALIMGELFQPGVGVDVSGVESMFSS
EYAAQGELPTFWATIIGMIPTNVFQSLNEANILQILVFCLFLGIAISKQAKEKRDPVINAVNTIVDAMVWMINKVMLIAP
IGVFGLMADAVGTFGFSALMVVFKLFVVYVAAIAIFGFVAYPVMIQLFSKTSAKKFIQAMKKPQAVALSTASSMATLPVT
MDTVKNDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIFFAQLFNIDLSMGAYIAIIVTATLGAVGQAGVPGPSFLVVA
VLLSAGIPIEGLPLLFALDRIFDMIRTALNITGDAACAVIVDSMITEEAAAELEKREA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=420, Percent_Identity=29.2857142857143, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI169790839, Length=462, Percent_Identity=27.9220779220779, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI66773030, Length=423, Percent_Identity=29.3144208037825, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI5032093, Length=394, Percent_Identity=30.7106598984772, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI223468566, Length=277, Percent_Identity=32.4909747292419, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=32.7137546468402, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4827012, Length=284, Percent_Identity=32.0422535211268, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI194239697, Length=441, Percent_Identity=26.530612244898, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI40254478, Length=426, Percent_Identity=28.6384976525822, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI301601644, Length=151, Percent_Identity=39.7350993377483, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI262359914, Length=381, Percent_Identity=26.509186351706, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1790514, Length=409, Percent_Identity=35.4523227383863, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1789947, Length=420, Percent_Identity=30, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1788024, Length=396, Percent_Identity=26.2626262626263, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789473, Length=277, Percent_Identity=29.2418772563177, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17537407, Length=420, Percent_Identity=29.5238095238095, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71983099, Length=404, Percent_Identity=29.7029702970297, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71983106, Length=420, Percent_Identity=29.0476190476191, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI193206505, Length=412, Percent_Identity=29.3689320388349, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI193206654, Length=408, Percent_Identity=30.8823529411765, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71996953, Length=423, Percent_Identity=26.9503546099291, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=419, Percent_Identity=30.0715990453461, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24583025, Length=413, Percent_Identity=26.3922518159806, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI17137668, Length=413, Percent_Identity=26.3922518159806, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24583023, Length=413, Percent_Identity=26.3922518159806, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI281360483, Length=437, Percent_Identity=27.0022883295195, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137666, Length=437, Percent_Identity=27.0022883295195, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360481, Length=437, Percent_Identity=27.0022883295195, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 48130; Mature: 48130

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLLLNVNIPCKKQEQNFCPFSDMTLVANTRNLQFISTEVMEVLKTKGLLNNIGVQVVIA
CEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
MLAGTAVGAAMGHDATLFAPLGAIFINLIKMLVIPLVAVALISGAAGLGDSHSAGKVGAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TLSYFAITSAAAVALALIMGELFQPGVGVDVSGVESMFSSEYAAQGELPTFWATIIGMIP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TNVFQSLNEANILQILVFCLFLGIAISKQAKEKRDPVINAVNTIVDAMVWMINKVMLIAP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVFGLMADAVGTFGFSALMVVFKLFVVYVAAIAIFGFVAYPVMIQLFSKTSAKKFIQAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKPQAVALSTASSMATLPVTMDTVKNDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIF
CCCCCEEEECCCCCEECCEEHHHHHHHCCCCCCCCCEEEECCCEEECCCCHHHHHHHHHH
FAQLFNIDLSMGAYIAIIVTATLGAVGQAGVPGPSFLVVAVLLSAGIPIEGLPLLFALDR
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
IFDMIRTALNITGDAACAVIVDSMITEEAAAELEKREA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCLLLNVNIPCKKQEQNFCPFSDMTLVANTRNLQFISTEVMEVLKTKGLLNNIGVQVVIA
CEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
MLAGTAVGAAMGHDATLFAPLGAIFINLIKMLVIPLVAVALISGAAGLGDSHSAGKVGAV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
TLSYFAITSAAAVALALIMGELFQPGVGVDVSGVESMFSSEYAAQGELPTFWATIIGMIP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TNVFQSLNEANILQILVFCLFLGIAISKQAKEKRDPVINAVNTIVDAMVWMINKVMLIAP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVFGLMADAVGTFGFSALMVVFKLFVVYVAAIAIFGFVAYPVMIQLFSKTSAKKFIQAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKPQAVALSTASSMATLPVTMDTVKNDLGVRNSTASFVLPLGATINMSGNAIYYGLVAIF
CCCCCEEEECCCCCEECCEEHHHHHHHCCCCCCCCCEEEECCCEEECCCCHHHHHHHHHH
FAQLFNIDLSMGAYIAIIVTATLGAVGQAGVPGPSFLVVAVLLSAGIPIEGLPLLFALDR
HHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHH
IFDMIRTALNITGDAACAVIVDSMITEEAAAELEKREA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]