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The map label for this gene is udp-1 [H]

Identifier: 227081207

GI number: 227081207

Start: 1057829

End: 1058605

Strand: Direct

Name: udp-1 [H]

Synonym: VCM66_0989

Alternate gene names: 227081207

Gene position: 1057829-1058605 (Clockwise)

Preceding gene: 227081206

Following gene: 227081210

Centisome position: 36.57

GC content: 52.51

Gene sequence:

>777_bases
TTGAAGGAGCCCCCTATGACCAAAACCGTATTCCACCTTGGTGTGACTGAAGCAGATTTAAACGGTGCCACACTCGCTAT
TATTCCGGGCGACCCTGCTCGTGTGCAGAAAATCGCGGAGCTGATGGATAACCCTGTTTTCCTCGCAAGCCATCGTGAAT
ATACCGTATACCGCGCAGAGCTGGATGGGCAGTCTGTGGTGGTGTGTTCAACCGGTATCGGTGGACCTTCAACATCGATT
GCGGTTGAAGAGTTAGCACAATTAGGCGTGCGTACTTTCTTGCGCGTTGGCACGACTGGTGCGATCCAGCCTCATGTGAA
TGTCGGTGACATGATTGTCACAACCGGTTCTGTGCGTTTGGATGGTGCAAGTCTGCACTTTGCGCCGATGGAATTCCCAG
CGGTACCGGATTTTGATGTGGCGACCGCAATGAAAGCGGCAGCACAAGAAAGCGGTGCAACAGTCCATATGGGTGTGACA
GCGTCCTCCGATACCTTCTACCCAGGCCAAGAGCGTTACGACACTTTCACTGGTCGCGTAGTGCGTCGTTTCCAAGGCTC
GATGAAAGAGTGGCAAGACATGGGCGTGCTCAACTTTGAAATGGAATCGGCAACTCTGCTGACCATGTGCGCGAGCTCTG
GTTTGAAAGCGGGCTGCGTGGCGGGTGTGATCATCAACCGTACTCAAAAAGAGATCCCAGATCACGCGACGTTGAAAGAA
ACCGAAGCGCGTTCTATCAAAGTTGTGGTGGAAGCTGCACGTAAGATGCTGAAATAA

Upstream 100 bases:

>100_bases
TTATTGCTGTCTTTGGTGTGATTGTTATCACTTATTTGCGCGAAGCTATCGGGTAAAGTAACTCCGTACCCTAAATGATA
AGTGCGCTGAATAGACGCAA

Downstream 100 bases:

>100_bases
GAGGCATATCTTCTTCACTGAATTAAAAAGCGCCACTTGATGTGGCGCTTTCTATTTCCTTTACCTACCCGTTTACGCCA
CAACAAGCTGTGGTAACGGG

Product: uridine phosphorylase

Products: NA

Alternate protein names: UPase; UrdPase [H]

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MKEPPMTKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSI
AVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVT
ASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKE
TEARSIKVVVEAARKMLK

Sequences:

>Translated_258_residues
MKEPPMTKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSI
AVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVT
ASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKE
TEARSIKVVVEAARKMLK
>Mature_258_residues
MKEPPMTKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAELDGQSVVVCSTGIGGPSTSI
AVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRLDGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVT
ASSDTFYPGQERYDTFTGRVVRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKE
TEARSIKVVVEAARKMLK

Specific function: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synth

COG id: COG2820

COG function: function code F; Uridine phosphorylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family [H]

Homologues:

Organism=Escherichia coli, GI1790265, Length=253, Percent_Identity=75.098814229249, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1790844, Length=239, Percent_Identity=30.1255230125523, Blast_Score=88, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018017
- InterPro:   IPR018016
- InterPro:   IPR000845
- InterPro:   IPR010058 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.3 [H]

Molecular weight: Translated: 27663; Mature: 27663

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01232 PNP_UDP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEPPMTKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAE
CCCCCCCCEEEEECCEEECCCCEEEEEECCCHHHHHHHHHHHCCCEEEECCCEEEEEEEE
LDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCEEE
DGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRV
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
VRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKE
HHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHCCCCCCCCC
TEARSIKVVVEAARKMLK
CCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEPPMTKTVFHLGVTEADLNGATLAIIPGDPARVQKIAELMDNPVFLASHREYTVYRAE
CCCCCCCCEEEEECCEEECCCCEEEEEECCCHHHHHHHHHHHCCCEEEECCCEEEEEEEE
LDGQSVVVCSTGIGGPSTSIAVEELAQLGVRTFLRVGTTGAIQPHVNVGDMIVTTGSVRL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCEEE
DGASLHFAPMEFPAVPDFDVATAMKAAAQESGATVHMGVTASSDTFYPGQERYDTFTGRV
CCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHH
VRRFQGSMKEWQDMGVLNFEMESATLLTMCASSGLKAGCVAGVIINRTQKEIPDHATLKE
HHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHCCCHHHHCCCCCCCCC
TEARSIKVVVEAARKMLK
CCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2674901; 1379743; 9278503; 8506346; 8899705; 9661793; 7796917; 12499542 [H]