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The map label for this gene is murQ2

Identifier: 227080871

GI number: 227080871

Start: 695163

End: 696086

Strand: Reverse

Name: murQ2

Synonym: VCM66_0648

Alternate gene names: 227080871

Gene position: 696086-695163 (Counterclockwise)

Preceding gene: 227080872

Following gene: 227080868

Centisome position: 24.07

GC content: 53.46

Gene sequence:

>924_bases
ATGACCAACGATGCACTTATCGCCGCGCTTTCTCATCTGGTTTCCGAAGGTCGTAACCCCGATACGATGGATATTGATTT
GCTCTCATCGCAAGAAATTGTCGAGCGGCTTAATCAACAAGACAAACAAGTGCCACTGGCGGTGGAAGCGGTATTGCCGC
AGATTGCCCAAGCGGTTGATAAAATCACTGCCGCCTTCAAACAAGGTGGCCGCTTGATCTACTTAGGGGCAGGTACCAGC
GGTCGTCTGGGTGTGCTGGATGCCTCAGAATGCCCACCCACTTTCGGAGTGAGCGATCAAATGGTGATTGGCCTGATTGC
CGGAGGCAAAGAGGCGATGTTTACCGCACAAGAAGGGGCGGAAGATAACGCCACGCTGGGCGCACATGATTTACAGCAAA
TCGACTTTAGCAGCAAAGATGTTCTAGTCGGGATTGCGGCGAGTGGCCGCACACCTTATGTGATTGGCGCGTTAGAGTAC
GCCAATGATTTAGGCGCGACCACCATCGCACTCTCGTGCAACCCTGATTCTCCGATTGCCGAAATCGCCCAGATTGCCAT
TTCTCCGGTCGTCGGGCCGGAAGCGTTAACGGGTTCAACCCGACTTAAATCCGGTACAGCGCAGAAGTTGGTGCTCAATA
TGCTCACGACTGCCAGCATGATCCGCCTTGGTAAAAGCTATCAAAATCTGATGGTCGATGTCCGAGCCACCAACCGCAAG
CTGATTGCCCGAGCGGTGCGAATTGTCATGCAAGCGACCGATTGCCAACGCGAAGAAGCCGAAGCACTACTCAAAGAGAG
CCACAACAACGCAAAACTGGCGATTTTGATGCATCTGACCGGCATGAACTACGAGCAAGCGACGGCGAAACTCTCGCAAT
CGGACGGCTTCTTACGCCGCGCCATGGAAGAGCACGAAGAGTAA

Upstream 100 bases:

>100_bases
TACACGGTTTACCCAGTAATTTGCCCGCCGTGACGGGCGCATCACGTCTTGCGAGTCTTGGCGTGATTTACTACCCCGAT
TAATCGCTACAGGAATTTTT

Downstream 100 bases:

>100_bases
TTAGCCAGAGCAAAACGAGAGCCCTATGGGCTCTCGTGACTTTTGATCAGAGACACGACAATTTCGCCCTCTTTCGGCGC
AAAACTCGCCACATCCTGAC

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase 2; N-acetylmuramic acid 6-phosphate hydrolase 2; N-acetylmuramic acid 6-phosphate lyase 2

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTNDALIAALSHLVSEGRNPDTMDIDLLSSQEIVERLNQQDKQVPLAVEAVLPQIAQAVDKITAAFKQGGRLIYLGAGTS
GRLGVLDASECPPTFGVSDQMVIGLIAGGKEAMFTAQEGAEDNATLGAHDLQQIDFSSKDVLVGIAASGRTPYVIGALEY
ANDLGATTIALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRLGKSYQNLMVDVRATNRK
LIARAVRIVMQATDCQREEAEALLKESHNNAKLAILMHLTGMNYEQATAKLSQSDGFLRRAMEEHEE

Sequences:

>Translated_307_residues
MTNDALIAALSHLVSEGRNPDTMDIDLLSSQEIVERLNQQDKQVPLAVEAVLPQIAQAVDKITAAFKQGGRLIYLGAGTS
GRLGVLDASECPPTFGVSDQMVIGLIAGGKEAMFTAQEGAEDNATLGAHDLQQIDFSSKDVLVGIAASGRTPYVIGALEY
ANDLGATTIALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRLGKSYQNLMVDVRATNRK
LIARAVRIVMQATDCQREEAEALLKESHNNAKLAILMHLTGMNYEQATAKLSQSDGFLRRAMEEHEE
>Mature_306_residues
TNDALIAALSHLVSEGRNPDTMDIDLLSSQEIVERLNQQDKQVPLAVEAVLPQIAQAVDKITAAFKQGGRLIYLGAGTSG
RLGVLDASECPPTFGVSDQMVIGLIAGGKEAMFTAQEGAEDNATLGAHDLQQIDFSSKDVLVGIAASGRTPYVIGALEYA
NDLGATTIALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRLGKSYQNLMVDVRATNRKL
IARAVRIVMQATDCQREEAEALLKESHNNAKLAILMHLTGMNYEQATAKLSQSDGFLRRAMEEHEE

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Homo sapiens, GI221625433, Length=256, Percent_Identity=28.125, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788768, Length=296, Percent_Identity=54.0540540540541, Blast_Score=322, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ2_VIBCH (Q9KU39)

Other databases:

- EMBL:   AE003852
- PIR:   G82291
- RefSeq:   NP_230339.1
- ProteinModelPortal:   Q9KU39
- SMR:   Q9KU39
- GeneID:   2615479
- GenomeReviews:   AE003852_GR
- KEGG:   vch:VC0690
- TIGR:   VC_0690
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK12570
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 32731; Mature: 32600

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 90-90 ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDALIAALSHLVSEGRNPDTMDIDLLSSQEIVERLNQQDKQVPLAVEAVLPQIAQAVD
CCCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KITAAFKQGGRLIYLGAGTSGRLGVLDASECPPTFGVSDQMVIGLIAGGKEAMFTAQEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCHHEEEECCCC
EDNATLGAHDLQQIDFSSKDVLVGIAASGRTPYVIGALEYANDLGATTIALSCNPDSPIA
CCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHCCCCCEEEEEEECCCCHHH
EIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRLGKSYQNLMVDVRATNRK
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHH
LIARAVRIVMQATDCQREEAEALLKESHNNAKLAILMHLTGMNYEQATAKLSQSDGFLRR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHH
AMEEHEE
HHHHHCC
>Mature Secondary Structure 
TNDALIAALSHLVSEGRNPDTMDIDLLSSQEIVERLNQQDKQVPLAVEAVLPQIAQAVD
CCHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
KITAAFKQGGRLIYLGAGTSGRLGVLDASECPPTFGVSDQMVIGLIAGGKEAMFTAQEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCCHHEEEECCCC
EDNATLGAHDLQQIDFSSKDVLVGIAASGRTPYVIGALEYANDLGATTIALSCNPDSPIA
CCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCEEEEHHHHHCCCCCEEEEEEECCCCHHH
EIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRLGKSYQNLMVDVRATNRK
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHH
LIARAVRIVMQATDCQREEAEALLKESHNNAKLAILMHLTGMNYEQATAKLSQSDGFLRR
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHH
AMEEHEE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301