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The map label for this gene is fkpB [H]

Identifier: 227080865

GI number: 227080865

Start: 689678

End: 690112

Strand: Direct

Name: fkpB [H]

Synonym: VCM66_0642

Alternate gene names: 227080865

Gene position: 689678-690112 (Clockwise)

Preceding gene: 227080864

Following gene: 227080866

Centisome position: 23.84

GC content: 50.34

Gene sequence:

>435_bases
GTGAACCCTATTGCCTCTAACTCTGCAGTTACCCTGCATTTTACGATCAAGCTTAAGGACGGCTCTGTTGCCGACAGTAC
CCATAATCAAGGAAAACCGGCCAAGCTAGTGATGGGCGATGGTAGCCTGAGCCCCAATTTCGAGCAGTGTTTACTCGGAA
TGTTGCCGGGCGAGAAAAAATCGGTCGCTTTAGCGGCGCAAGATGCGTTTGGCGCGCCCAATCCAGATCATGTCCATTAC
ATGGATCGCAGTAAGTTTCTTGGTGGTGATCTGCAGTTAGAGGTCGGAACCATTATGGCTTTCAGTGGCCCTGACGGAAT
GGAAATTCCCGGAATCATCACGGAGATCGCCGGTGACTCAGTGACTGTCGATTTCAATCACCCATTGGCAGGGCAAGACA
TCACCTTTGATGTTGAGATCTTGTCTGTTGAGTGA

Upstream 100 bases:

>100_bases
ATTCGGAGGGCGCTTTTTACTATAAAGGCTGGCATCAGCGCCCGCTCGTCGCCGCTAAAGTGAAGCGGCGTTCGTTAAAC
AATAACAAGGTAGTGATAAC

Downstream 100 bases:

>100_bases
GTTTCCTTACAATAGCCAACCATAACGACTAGCAATGAGCAAACCAATGAAAATACTGTTAGCCAACCCTCGCGGTTTCT
GCGCGGGTGTGGATCGCGCG

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MNPIASNSAVTLHFTIKLKDGSVADSTHNQGKPAKLVMGDGSLSPNFEQCLLGMLPGEKKSVALAAQDAFGAPNPDHVHY
MDRSKFLGGDLQLEVGTIMAFSGPDGMEIPGIITEIAGDSVTVDFNHPLAGQDITFDVEILSVE

Sequences:

>Translated_144_residues
MNPIASNSAVTLHFTIKLKDGSVADSTHNQGKPAKLVMGDGSLSPNFEQCLLGMLPGEKKSVALAAQDAFGAPNPDHVHY
MDRSKFLGGDLQLEVGTIMAFSGPDGMEIPGIITEIAGDSVTVDFNHPLAGQDITFDVEILSVE
>Mature_144_residues
MNPIASNSAVTLHFTIKLKDGSVADSTHNQGKPAKLVMGDGSLSPNFEQCLLGMLPGEKKSVALAAQDAFGAPNPDHVHY
MDRSKFLGGDLQLEVGTIMAFSGPDGMEIPGIITEIAGDSVTVDFNHPLAGQDITFDVEILSVE

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=141, Percent_Identity=51.7730496453901, Blast_Score=152, Evalue=7e-39,
Organism=Escherichia coli, GI1789748, Length=142, Percent_Identity=33.8028169014084, Blast_Score=70, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15180; Mature: 15180

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIASNSAVTLHFTIKLKDGSVADSTHNQGKPAKLVMGDGSLSPNFEQCLLGMLPGEKK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCC
SVALAAQDAFGAPNPDHVHYMDRSKFLGGDLQLEVGTIMAFSGPDGMEIPGIITEIAGDS
EEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCEEEECCCCE
VTVDFNHPLAGQDITFDVEILSVE
EEEEECCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure
MNPIASNSAVTLHFTIKLKDGSVADSTHNQGKPAKLVMGDGSLSPNFEQCLLGMLPGEKK
CCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCC
SVALAAQDAFGAPNPDHVHYMDRSKFLGGDLQLEVGTIMAFSGPDGMEIPGIITEIAGDS
EEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEEEEEEEECCCCCCCCCCEEEECCCCE
VTVDFNHPLAGQDITFDVEILSVE
EEEEECCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]