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The map label for this gene is yciR [C]

Identifier: 227080834

GI number: 227080834

Start: 654803

End: 656857

Strand: Reverse

Name: yciR [C]

Synonym: VCM66_0611

Alternate gene names: 227080834

Gene position: 656857-654803 (Counterclockwise)

Preceding gene: 227080839

Following gene: 227080833

Centisome position: 22.71

GC content: 47.54

Gene sequence:

>2055_bases
ATGCCTGCTCAAACCTCATCTCAGCTCAAGCATTGGTTTGCAAAAATTACGTCACACAGTCCGTTCTTTTTTGCAATCCT
CAATGATCAACACCAATACGTGATGGTCAACGAGCGCTATTGTGATATCGCCGGTCTCTCTAGCGAAGAGATGGTCGGGA
TGAGCGATAGTCAGGTTCTGGGCGAACATTTTTATCGCCATCTCAAACCGTTTTACGAACGTGCGTTTAACAACGAGCAT
ATTGAGTCCGAGCTGACCCTCAGCGAAATCGACCTCGAAACCAGCTTACACTTTTCTCTCTCCCCCATCATGATCAACGA
TCGGGTGCAATACCTTGTATTCCACGCGATTGATACCTCAGAAAAGCAGATTTTAGTGCGCTCTCTGGAAGAATCGGAAA
GCAAATACGCACTCCTCACGACACTGCTACCTGATGGTTTAATGATGGTGGAAAATGACTGCATTATTTCTGCCAACCCT
TCCGCTGCACGTTTACTCGGTTTTGACGACGCACAAAAACTGCTCGGAGAAAATCTCTCCAGACTGTTTATTGATGAAAA
GACCAAAACCGTTTTTTCATCGCAGTTGGCTTCGCTACTGACAGAAAAACCCTTGGTGTGCTTGACCGGGCCAAGGTGTG
GGTTTGAACGGAAAATCCAGTTACACGCAGGTTGCACCTCTTTACTCGGTAATCAGTCGCAGTTGATCTTATTGCAAGAT
GCCGATGAAGCCCCAAAACAGTTTTCTGCGACCACTCAAGTCGATGCGCATATTGATAGCCTCACTGGGCTGTATAACCG
ACACGGGTTTACCAAGCGCTTAGAGCAGTGCATCCAAAATGAGACGCCTTTGGTTATGCTCTATCTGGACATTGATAACT
TCAAAAACATCAATGACTCTCTCGGCCATCACATCGGTGACAAAGTGATTAAAGAGGTGGCGGCACGTTTAAAACGCTTA
CTGCCACAGCAAGCCGTACTTGGCCATTTGGGCGGTGATGAGTTTGGTTTGATCTTGCCGGAGCCAGAACACAACCGCTC
TGCAGAAATGTTGGCAGATCGCATTATCTCTTTGATTAATCAGCCTTTTGACCTGCACCATTTCAGTAAGCGTTTAGCTT
GTTCGATTGGCAGCGTGCGTTATCCCGGTGACGGCAATGATGCTCGCGTATTACTGCAAAATGCCGATACCGCGATGTAT
GAGGCTAAAGAGCGCGGTCGCAATCGCCTGATCAAATTCAATGATCAGATGAACAAAGAAGCGCGGATGCGCCTTTGGTT
GGAAATTGAACTGCAAAAAGCGCTACAACAAAACGGCCTAGAAGTGTGGTACCAACCGAAAGTCAACGCGCGTGATTTTA
GCATCAATGGCGCAGAAGCCTTGGTACGCTGGAAACATCCCGTTGAAGGCTATATCAGCCCAGGTGCTTTCATTCCCGTT
GCGGAAAAAGCCGGCTTAATCGAACATTTGGGTCGCGTGGTTATGCGTGAAGTCTTCGCGACCGTCAAGCGCTGGAAGCT
ACAAGGCATTTTACCCGGACGTGTGGCGATCAACATCTCCCCCGAGCAGTTTGGCAATCCTCAACTGATTGATTATTTAG
AAAAACTACTGCGAACAACTGGGCTAGATCCCAACAACATCACATTTGAACTGACCGAAAGTGCGGTGATGAGCGATAGT
GAACATACCCAGCAAATGCTCAATGCCATCAAGAAACTCGGCTTCACCTTGTCAATTGATGACTTCGGTACAGGTTACTC
GTCGCTGGCTTATTTAGCTCGCTTCCCGATCGATGAGCTCAAAATCGACCGCGCGTTTATCAGTAATATCGACACTCTAC
CCAAACAGCTCACGGTGATTGAAAACATCATTAATTTGGGGCGCTCACTGAACCTGACCGTAGTTGCAGAAGGAGTAGAA
ACTCAGCAACAAGCCACTTTACTCTCCAACCTAAATTGCCACTCCATCCAAGGCTTCCATTTTTATCGCCCACAACCGAA
GCACGAAGTGGAAGAGTTGTTTGCGCAAAATCGCCGCCATCGCAAATCCCTCTAA

Upstream 100 bases:

>100_bases
AATCATGTTACCGAATTGGTAACGCTATACCCCAACGACATACGCTGTTAAAGGGGATATTATAAACGTCGTCGCGCACG
GACAGTTGGTAGTATTTTAA

Downstream 100 bases:

>100_bases
GGGGTTAATTTTACTCTGATTGGTGGAAACCTGCCTTACATCAAATCGGGGAGACTCAATCCTTCCTAAAATGCGTTCAC
TATTCCCTGAATTCAGAGCC

Product: c-di-GMP phosphodiesterase A-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 684; Mature: 683

Protein sequence:

>684_residues
MPAQTSSQLKHWFAKITSHSPFFFAILNDQHQYVMVNERYCDIAGLSSEEMVGMSDSQVLGEHFYRHLKPFYERAFNNEH
IESELTLSEIDLETSLHFSLSPIMINDRVQYLVFHAIDTSEKQILVRSLEESESKYALLTTLLPDGLMMVENDCIISANP
SAARLLGFDDAQKLLGENLSRLFIDEKTKTVFSSQLASLLTEKPLVCLTGPRCGFERKIQLHAGCTSLLGNQSQLILLQD
ADEAPKQFSATTQVDAHIDSLTGLYNRHGFTKRLEQCIQNETPLVMLYLDIDNFKNINDSLGHHIGDKVIKEVAARLKRL
LPQQAVLGHLGGDEFGLILPEPEHNRSAEMLADRIISLINQPFDLHHFSKRLACSIGSVRYPGDGNDARVLLQNADTAMY
EAKERGRNRLIKFNDQMNKEARMRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPV
AEKAGLIEHLGRVVMREVFATVKRWKLQGILPGRVAINISPEQFGNPQLIDYLEKLLRTTGLDPNNITFELTESAVMSDS
EHTQQMLNAIKKLGFTLSIDDFGTGYSSLAYLARFPIDELKIDRAFISNIDTLPKQLTVIENIINLGRSLNLTVVAEGVE
TQQQATLLSNLNCHSIQGFHFYRPQPKHEVEELFAQNRRHRKSL

Sequences:

>Translated_684_residues
MPAQTSSQLKHWFAKITSHSPFFFAILNDQHQYVMVNERYCDIAGLSSEEMVGMSDSQVLGEHFYRHLKPFYERAFNNEH
IESELTLSEIDLETSLHFSLSPIMINDRVQYLVFHAIDTSEKQILVRSLEESESKYALLTTLLPDGLMMVENDCIISANP
SAARLLGFDDAQKLLGENLSRLFIDEKTKTVFSSQLASLLTEKPLVCLTGPRCGFERKIQLHAGCTSLLGNQSQLILLQD
ADEAPKQFSATTQVDAHIDSLTGLYNRHGFTKRLEQCIQNETPLVMLYLDIDNFKNINDSLGHHIGDKVIKEVAARLKRL
LPQQAVLGHLGGDEFGLILPEPEHNRSAEMLADRIISLINQPFDLHHFSKRLACSIGSVRYPGDGNDARVLLQNADTAMY
EAKERGRNRLIKFNDQMNKEARMRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPV
AEKAGLIEHLGRVVMREVFATVKRWKLQGILPGRVAINISPEQFGNPQLIDYLEKLLRTTGLDPNNITFELTESAVMSDS
EHTQQMLNAIKKLGFTLSIDDFGTGYSSLAYLARFPIDELKIDRAFISNIDTLPKQLTVIENIINLGRSLNLTVVAEGVE
TQQQATLLSNLNCHSIQGFHFYRPQPKHEVEELFAQNRRHRKSL
>Mature_683_residues
PAQTSSQLKHWFAKITSHSPFFFAILNDQHQYVMVNERYCDIAGLSSEEMVGMSDSQVLGEHFYRHLKPFYERAFNNEHI
ESELTLSEIDLETSLHFSLSPIMINDRVQYLVFHAIDTSEKQILVRSLEESESKYALLTTLLPDGLMMVENDCIISANPS
AARLLGFDDAQKLLGENLSRLFIDEKTKTVFSSQLASLLTEKPLVCLTGPRCGFERKIQLHAGCTSLLGNQSQLILLQDA
DEAPKQFSATTQVDAHIDSLTGLYNRHGFTKRLEQCIQNETPLVMLYLDIDNFKNINDSLGHHIGDKVIKEVAARLKRLL
PQQAVLGHLGGDEFGLILPEPEHNRSAEMLADRIISLINQPFDLHHFSKRLACSIGSVRYPGDGNDARVLLQNADTAMYE
AKERGRNRLIKFNDQMNKEARMRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPVA
EKAGLIEHLGRVVMREVFATVKRWKLQGILPGRVAINISPEQFGNPQLIDYLEKLLRTTGLDPNNITFELTESAVMSDSE
HTQQMLNAIKKLGFTLSIDDFGTGYSSLAYLARFPIDELKIDRAFISNIDTLPKQLTVIENIINLGRSLNLTVVAEGVET
QQQATLLSNLNCHSIQGFHFYRPQPKHEVEELFAQNRRHRKSL

Specific function: Unknown

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MHYT domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=421, Percent_Identity=37.0546318289786, Blast_Score=288, Evalue=6e-79,
Organism=Escherichia coli, GI87081921, Length=412, Percent_Identity=33.252427184466, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI226510982, Length=425, Percent_Identity=27.7647058823529, Blast_Score=176, Evalue=5e-45,
Organism=Escherichia coli, GI87081845, Length=236, Percent_Identity=36.0169491525424, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788502, Length=243, Percent_Identity=36.6255144032922, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI1790496, Length=237, Percent_Identity=34.5991561181435, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1786507, Length=237, Percent_Identity=33.3333333333333, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1787055, Length=362, Percent_Identity=26.5193370165746, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI87081980, Length=252, Percent_Identity=34.5238095238095, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081743, Length=240, Percent_Identity=33.75, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI87082096, Length=417, Percent_Identity=25.1798561151079, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1788849, Length=252, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1788381, Length=195, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1787262, Length=171, Percent_Identity=33.9181286549708, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI145693134, Length=170, Percent_Identity=32.3529411764706, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788956, Length=158, Percent_Identity=33.5443037974684, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1787802, Length=160, Percent_Identity=32.5, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082007, Length=169, Percent_Identity=34.3195266272189, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1786584, Length=166, Percent_Identity=33.1325301204819, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI87081881, Length=219, Percent_Identity=30.5936073059361, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788085, Length=160, Percent_Identity=30, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787410, Length=152, Percent_Identity=29.6052631578947, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789650, Length=436, Percent_Identity=18.8073394495413, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87081977, Length=194, Percent_Identity=31.4432989690722, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787816, Length=168, Percent_Identity=30.952380952381, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI87081974, Length=96, Percent_Identity=35.4166666666667, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 77475; Mature: 77343

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQTSSQLKHWFAKITSHSPFFFAILNDQHQYVMVNERYCDIAGLSSEEMVGMSDSQVL
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCEECCCCCCCCCCCCCCHHHHH
GEHFYRHLKPFYERAFNNEHIESELTLSEIDLETSLHFSLSPIMINDRVQYLVFHAIDTS
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEECCEEECCCEEEEEEEEECCC
EKQILVRSLEESESKYALLTTLLPDGLMMVENDCIISANPSAARLLGFDDAQKLLGENLS
HHHHHHHHHHHCCCCEEEEEHHCCCCEEEEECCEEEECCCCHHEEECCHHHHHHHHCCHH
RLFIDEKTKTVFSSQLASLLTEKPLVCLTGPRCGFERKIQLHAGCTSLLGNQSQLILLQD
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCHHHHHCCCCCEEEEEC
ADEAPKQFSATTQVDAHIDSLTGLYNRHGFTKRLEQCIQNETPLVMLYLDIDNFKNINDS
CCCCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
LGHHIGDKVIKEVAARLKRLLPQQAVLGHLGGDEFGLILPEPEHNRSAEMLADRIISLIN
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHC
QPFDLHHFSKRLACSIGSVRYPGDGNDARVLLQNADTAMYEAKERGRNRLIKFNDQMNKE
CCCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCC
ARMRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPV
CCEEEEEEEHHHHHHHHCCCEEEECCCCCCCEECCCCHHHHEEECCCCCCCCCCCCEEEC
AEKAGLIEHLGRVVMREVFATVKRWKLQGILPGRVAINISPEQFGNPQLIDYLEKLLRTT
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHCCCCHHHHHHHHHHHHC
GLDPNNITFELTESAVMSDSEHTQQMLNAIKKLGFTLSIDDFGTGYSSLAYLARFPIDEL
CCCCCCEEEEEEHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHH
KIDRAFISNIDTLPKQLTVIENIINLGRSLNLTVVAEGVETQQQATLLSNLNCHSIQGFH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCEECCEE
FYRPQPKHEVEELFAQNRRHRKSL
ECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAQTSSQLKHWFAKITSHSPFFFAILNDQHQYVMVNERYCDIAGLSSEEMVGMSDSQVL
CCCCHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCEECCCCCCCCCCCCCCHHHHH
GEHFYRHLKPFYERAFNNEHIESELTLSEIDLETSLHFSLSPIMINDRVQYLVFHAIDTS
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCEEEEEEECCEEECCCEEEEEEEEECCC
EKQILVRSLEESESKYALLTTLLPDGLMMVENDCIISANPSAARLLGFDDAQKLLGENLS
HHHHHHHHHHHCCCCEEEEEHHCCCCEEEEECCEEEECCCCHHEEECCHHHHHHHHCCHH
RLFIDEKTKTVFSSQLASLLTEKPLVCLTGPRCGFERKIQLHAGCTSLLGNQSQLILLQD
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEECCHHHHHCCCCCEEEEEC
ADEAPKQFSATTQVDAHIDSLTGLYNRHGFTKRLEQCIQNETPLVMLYLDIDNFKNINDS
CCCCHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
LGHHIGDKVIKEVAARLKRLLPQQAVLGHLGGDEFGLILPEPEHNRSAEMLADRIISLIN
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHC
QPFDLHHFSKRLACSIGSVRYPGDGNDARVLLQNADTAMYEAKERGRNRLIKFNDQMNKE
CCCCHHHHHHHHHHHCCCEECCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCC
ARMRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPV
CCEEEEEEEHHHHHHHHCCCEEEECCCCCCCEECCCCHHHHEEECCCCCCCCCCCCEEEC
AEKAGLIEHLGRVVMREVFATVKRWKLQGILPGRVAINISPEQFGNPQLIDYLEKLLRTT
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECHHHCCCCHHHHHHHHHHHHC
GLDPNNITFELTESAVMSDSEHTQQMLNAIKKLGFTLSIDDFGTGYSSLAYLARFPIDEL
CCCCCCEEEEEEHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHH
KIDRAFISNIDTLPKQLTVIENIINLGRSLNLTVVAEGVETQQQATLLSNLNCHSIQGFH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCEECCEE
FYRPQPKHEVEELFAQNRRHRKSL
ECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]