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The map label for this gene is vmrA [H]

Identifier: 227080831

GI number: 227080831

Start: 651402

End: 652739

Strand: Direct

Name: vmrA [H]

Synonym: VCM66_0608

Alternate gene names: 227080831

Gene position: 651402-652739 (Clockwise)

Preceding gene: 227080830

Following gene: 227080835

Centisome position: 22.52

GC content: 50.6

Gene sequence:

>1338_bases
ATGATGAATCGATCGATTTACCGACAGTTTGTTCGCTACACCATTCCTACGGTGGCTGCGATGCTGGTTAATGGTCTGTA
TCAAGTGGTGGATGGCATCTTCATTGGCCATTATGTGGGCGCTGAGGGATTAGCTGGCATTAACGTGGCTTGGCCTGTGA
TCGGTACCATCCTCGGGATCGGTATGCTGGTTGGGGTGGGCACTGGAGCTCTGGCTTCAATCAAACAGGGGGAAGGCCAT
CCTGACAGTGCTAAGCGTATTCTGGCCACTGGGTTGATGAGTTTGCTGCTACTTGCCCCTATCGTGGCTGTGATTTTGTG
GTTTATGGCGGATGACTTCTTGCGTTGGCAAGGCGCTGAAGGAAGGGTGTTTGAATTAGGCCTGCAGTACCTACAAGTGT
TAATTGTTGGCTGTTTGTTCACCTTAGGCTCGATTGCGATGCCGTTTTTGCTACGTAACGATCACAGCCCCAATTTGGCT
ACGTTATTAATGGTGATTGGTGCACTGACCAATATCGCACTTGATTACCTGTTTATCGCTTGGCTGCAATGGGAGCTGAC
CGGTGCAGCGATCGCCACCACTCTTGCGCAGGTGGTGGTCACGTTATTAGGCTTGGCGTATTTCTTTTCTGCCCGAGCCA
ATATGCGTTTAACTCGTCGTTGCTTAAGGTTGGAGTGGCACTCGTTACCCAAGATCTTCGCGATTGGCGTCTCAAGCTTT
TTTATGTACGCCTACGGTTCCACCATGGTCGCGCTGCACAACACCTTGATGATCGAGTACGGCAACGCCGTCATGGTCGG
TGCTTATGCGGTGATGGGTTACATAGTGACGATCTACTACCTGACCGTTGAAGGTATTGCGAATGGTATGCAGCCGCTGG
CCAGCTACCATTTTGGGGCGCGTAATTACGATCACATCCGTAAGTTATTACGCTTGGCGATGGGGATTGCCGTACTGGGA
GGGATGGCGTTTGTGCTGGTGCTAAACCTCTTCCCTGAGCAGGCGATTGCGATATTTAACTCCAGCGACAGCGAATTGAT
CGCCGGAGCGCAAATGGGCATTAAGCTGCACCTGTTTGCGATGTATCTTGATGGTTTCTTAGTGGTGAGCGCGGCGTATT
ACCAATCCACCAATCGCGGTGGCAAAGCCATGTTTATTACCGTGGGGAATATGTCGATCATGTTACCCTTCTTGTTTATT
TTGCCGCAGTTTTTTGGGCTGACAGGGGTATGGATCGCCTTACCCATCTCCAATATTGTGCTGAGCACTGTGGTCGGCAT
TATGCTCTGGCGCGATGTGAACAAAATGGGGAAACCTACCCAAGTTTCCTATGCATGA

Upstream 100 bases:

>100_bases
TCTTCTGAAGAAGCGATGATGCTGGACTTGTTATTGGGTAAAGCCCTGCGCTAGTCAGGTTTTTATTAGATAGGCTAACT
AACTAAATAGATATGTTTGT

Downstream 100 bases:

>100_bases
AAAGGAAAAGGCAAATAAAAAGGGTTGCTGATGAGCAACCCTTTGGTAAACCTTAGCTATTTTTAACGGCCAAACCAGCT
AATTGATGCCAGTAACCGTT

Product: multidrug efflux pump VmrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MMNRSIYRQFVRYTIPTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGIGMLVGVGTGALASIKQGEGH
PDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAEGRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNLA
TLLMVIGALTNIALDYLFIAWLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSSF
FMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGARNYDHIRKLLRLAMGIAVLG
GMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFAMYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLFI
LPQFFGLTGVWIALPISNIVLSTVVGIMLWRDVNKMGKPTQVSYA

Sequences:

>Translated_445_residues
MMNRSIYRQFVRYTIPTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGIGMLVGVGTGALASIKQGEGH
PDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAEGRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNLA
TLLMVIGALTNIALDYLFIAWLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSSF
FMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGARNYDHIRKLLRLAMGIAVLG
GMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFAMYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLFI
LPQFFGLTGVWIALPISNIVLSTVVGIMLWRDVNKMGKPTQVSYA
>Mature_445_residues
MMNRSIYRQFVRYTIPTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGIGMLVGVGTGALASIKQGEGH
PDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAEGRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNLA
TLLMVIGALTNIALDYLFIAWLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSSF
FMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGARNYDHIRKLLRLAMGIAVLG
GMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFAMYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLFI
LPQFFGLTGVWIALPISNIVLSTVVGIMLWRDVNKMGKPTQVSYA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48636; Mature: 48636

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNRSIYRQFVRYTIPTVAAMLVNGLYQVVDGIFIGHYVGAEGLAGINVAWPVIGTILGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
GMLVGVGTGALASIKQGEGHPDSAKRILATGLMSLLLLAPIVAVILWFMADDFLRWQGAE
HHHHHCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GRVFELGLQYLQVLIVGCLFTLGSIAMPFLLRNDHSPNLATLLMVIGALTNIALDYLFIA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
WLQWELTGAAIATTLAQVVVTLLGLAYFFSARANMRLTRRCLRLEWHSLPKIFAIGVSSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
FMYAYGSTMVALHNTLMIEYGNAVMVGAYAVMGYIVTIYYLTVEGIANGMQPLASYHFGA
HHHHHCCHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RNYDHIRKLLRLAMGIAVLGGMAFVLVLNLFPEQAIAIFNSSDSELIAGAQMGIKLHLFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEECCCCCCCHHHHHCCHHHHHHH
MYLDGFLVVSAAYYQSTNRGGKAMFITVGNMSIMLPFLFILPQFFGLTGVWIALPISNIV
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
LSTVVGIMLWRDVNKMGKPTQVSYA
HHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA