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The map label for this gene is trxA [H]

Identifier: 227080520

GI number: 227080520

Start: 302498

End: 302824

Strand: Direct

Name: trxA [H]

Synonym: VCM66_0291

Alternate gene names: 227080520

Gene position: 302498-302824 (Clockwise)

Preceding gene: 227080517

Following gene: 227080521

Centisome position: 10.46

GC content: 48.01

Gene sequence:

>327_bases
ATGAGTGACAAAATTTTGCAGCTGACCGATGACGGTTTCGAGAACGATGTAATCAAAGCTGCAGGCCCGGTTCTAGTTGA
CTTTTGGGCGGAGTGGTGTGGTCCTTGTAAGATGATTGCCCCGATCCTAGATGAAGTGGCTGACGAATACGCAGGCAAAC
TCACTATCGGTAAACTGAATATTGACCATAACGCGGGAACACCACCTAAGTTTGGTATCCGCGGCATCCCAACACTGCTG
CTGTTTAAAGATGGCAGTGTGGTAGCGACTAAAGTTGGTGCGCTATCAAAGACTCAACTGAAAGAGTTCCTAGACGCGAA
CCTGTAA

Upstream 100 bases:

>100_bases
ATCAGCTTACGCTTGCAATACGGAAGTAAATACATTCCAATAGAGCATCTATTTACTGGTTGAGTTATCACCAGTGCAGA
AAATCACATTGGAGTGAAAG

Downstream 100 bases:

>100_bases
TGAGTCAGACCGCCAAGCCGTACATAGCAATATGTACGGTTTTGTTTTTGGCAAAAAACAATTTCTAGACTAGGCTAATA
TTTAGTGCTAGTTTATCGCA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1 [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDKILQLTDDGFENDVIKAAGPVLVDFWAEWCGPCKMIAPILDEVADEYAGKLTIGKLNIDHNAGTPPKFGIRGIPTLL
LFKDGSVVATKVGALSKTQLKEFLDANL

Sequences:

>Translated_108_residues
MSDKILQLTDDGFENDVIKAAGPVLVDFWAEWCGPCKMIAPILDEVADEYAGKLTIGKLNIDHNAGTPPKFGIRGIPTLL
LFKDGSVVATKVGALSKTQLKEFLDANL
>Mature_107_residues
SDKILQLTDDGFENDVIKAAGPVLVDFWAEWCGPCKMIAPILDEVADEYAGKLTIGKLNIDHNAGTPPKFGIRGIPTLLL
FKDGSVVATKVGALSKTQLKEFLDANL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=36.9565217391304, Blast_Score=77, Evalue=2e-15,
Organism=Homo sapiens, GI21361657, Length=83, Percent_Identity=40.9638554216867, Blast_Score=72, Evalue=9e-14,
Organism=Homo sapiens, GI5031973, Length=100, Percent_Identity=29, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=80.5555555555556, Blast_Score=183, Evalue=2e-48,
Organism=Escherichia coli, GI1788936, Length=109, Percent_Identity=40.3669724770642, Blast_Score=90, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=37.6344086021505, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=42.2535211267606, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=35.5555555555556, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=40.2298850574713, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=87, Percent_Identity=37.9310344827586, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=100, Percent_Identity=35, Blast_Score=65, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=42.8571428571429, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=85, Percent_Identity=37.6470588235294, Blast_Score=67, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=41.0958904109589, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=34.375, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24664269, Length=96, Percent_Identity=32.2916666666667, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17648013, Length=106, Percent_Identity=33.0188679245283, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=106, Percent_Identity=33.0188679245283, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=35.2272727272727, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24639068, Length=103, Percent_Identity=29.126213592233, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11645; Mature: 11513

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKILQLTDDGFENDVIKAAGPVLVDFWAEWCGPCKMIAPILDEVADEYAGKLTIGKLN
CCCCEEEECCCCCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEE
IDHNAGTPPKFGIRGIPTLLLFKDGSVVATKVGALSKTQLKEFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCEEEEHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
SDKILQLTDDGFENDVIKAAGPVLVDFWAEWCGPCKMIAPILDEVADEYAGKLTIGKLN
CCCEEEECCCCCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEEEEE
IDHNAGTPPKFGIRGIPTLLLFKDGSVVATKVGALSKTQLKEFLDANL
ECCCCCCCCCCCCCCCCEEEEEECCCEEEEHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]