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The map label for this gene is serA [H]

Identifier: 226951046

GI number: 226951046

Start: 4105366

End: 4106313

Strand: Reverse

Name: serA [H]

Synonym: CLM_4085

Alternate gene names: 226951046

Gene position: 4106313-4105366 (Counterclockwise)

Preceding gene: 226951047

Following gene: 226951045

Centisome position: 98.82

GC content: 25.42

Gene sequence:

>948_bases
ATGAGCATAAAAGCATTATTTACTTATAATTATGGTAAAGAAAACATGAAAAAAATAGAAAACTTAGGTTATGATATAAC
TATAATAAATGAAAAAGAAATAAAATATAAAGATCAGATTAAAGATATGGAAGTTTTGGTTTGTTATAATCCTTTTAGCA
CTTTAGATATATCTCTTATGAAAAACTTAAAATGGATACAACTTTCAAGCACAGGTGTAGATCAAGTACCTAAGGACATT
GTTTTAAAAAATAATGTTATAGTTACTAATAATAATGGAGGATATTCTATACCAATAGCAGAATGGATTGTTTTAAAGAC
ATTAGAACTTTTAAAAAATAGTAAGGAATTTTATAAAAAACAAGAGAATAAGATTTGGAAACTAGATACCAGTTTATTAG
AGCTATGTGGAAAAACTATAGGATTTATAGGAACTGGAAACATTGCAAAAGAGGCAGCTAAAAGATTTTCAGGTTTTAAT
GTTAATATATTAGGAGTTAATACCAAAGGAAGAGAGGTAGAGTATTTTAATAAGTGCTATTCTAAAGATAATATAAAAGA
AATGGTTTCAAAGAGTGATATTATAATATTAAGTATACCTTATACCAAAGAAACAGAAAATTTAGTAGATGAAAATGTAC
TAAACAGTATGAAGAGTGGAGCATTATTTATAAATATATCAAGGGGTTCTATTGTAGATGAGAGAAAACTTATAGAAAAT
TTAAAACTAGGAAAAATAAAAGGAGCAGCATTGGATGTATTTGAAGAAGAGCCTTTATTTAGAGATAATCCTATTTGGGA
ATTGGATAATGCCATAATAACTCCTCATAATTCTTGGATTTCTGAAAAAAGAAATATTAGAAGATTTGATATAATATACG
AAAACTTAAAAAATTATAAAGAGGGAACGGAATTAAAAAGCGTTGTTAATATGAATAAAGGTTATTAA

Upstream 100 bases:

>100_bases
AGTAAATATAAATAGTGATTTGATTGAATTTTCAATATATTAATGATAAAATCAAAATTAACTTTAAATTATTAAAAGTA
AAAGAGGGAGAAGGATAGTA

Downstream 100 bases:

>100_bases
AATTAAAGGTATAATTTAAGGTGATTTTATGAATGAAAGAAAGCTTAGGATATTTTATGAAGTAGCAGAAAAACTTAATA
TGACAGAAGTGGCAGAAAAG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSIKALFTYNYGKENMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLMKNLKWIQLSSTGVDQVPKDI
VLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKKQENKIWKLDTSLLELCGKTIGFIGTGNIAKEAAKRFSGFN
VNILGVNTKGREVEYFNKCYSKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKSGALFINISRGSIVDERKLIEN
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYKEGTELKSVVNMNKGY

Sequences:

>Translated_315_residues
MSIKALFTYNYGKENMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLMKNLKWIQLSSTGVDQVPKDI
VLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKKQENKIWKLDTSLLELCGKTIGFIGTGNIAKEAAKRFSGFN
VNILGVNTKGREVEYFNKCYSKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKSGALFINISRGSIVDERKLIEN
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYKEGTELKSVVNMNKGY
>Mature_314_residues
SIKALFTYNYGKENMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLMKNLKWIQLSSTGVDQVPKDIV
LKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKKQENKIWKLDTSLLELCGKTIGFIGTGNIAKEAAKRFSGFNV
NILGVNTKGREVEYFNKCYSKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKSGALFINISRGSIVDERKLIENL
KLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYKEGTELKSVVNMNKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=233, Percent_Identity=31.7596566523605, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI23308577, Length=255, Percent_Identity=27.843137254902, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557497, Length=165, Percent_Identity=31.5151515151515, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI61743967, Length=165, Percent_Identity=31.5151515151515, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580578, Length=176, Percent_Identity=28.9772727272727, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4557499, Length=176, Percent_Identity=28.9772727272727, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=25.3968253968254, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87082289, Length=258, Percent_Identity=28.2945736434109, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789279, Length=228, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081824, Length=219, Percent_Identity=24.6575342465753, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787645, Length=328, Percent_Identity=23.780487804878, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=248, Percent_Identity=30.241935483871, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25147481, Length=155, Percent_Identity=31.6129032258064, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=229, Percent_Identity=29.6943231441048, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=229, Percent_Identity=28.82096069869, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=329, Percent_Identity=24.0121580547112, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=163, Percent_Identity=28.8343558282209, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=202, Percent_Identity=25.2475247524752, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574286, Length=242, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921140, Length=236, Percent_Identity=28.8135593220339, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI45552429, Length=224, Percent_Identity=30.8035714285714, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24585514, Length=224, Percent_Identity=30.8035714285714, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574282, Length=224, Percent_Identity=30.8035714285714, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28574284, Length=224, Percent_Identity=30.8035714285714, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45551003, Length=224, Percent_Identity=30.8035714285714, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571528, Length=143, Percent_Identity=33.5664335664336, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=24.7011952191235, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24646446, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646448, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646452, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646450, Length=160, Percent_Identity=29.375, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI62472511, Length=187, Percent_Identity=26.2032085561497, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36194; Mature: 36063

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKALFTYNYGKENMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLM
CCEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCHHHCCCCEEEEEEECCCCHHHHHHH
KNLKWIQLSSTGVDQVPKDIVLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKK
CCCEEEEEECCCHHHCCHHHEEECCEEEECCCCCEECHHHHHHHHHHHHHHHCCHHHHHH
QENKIWKLDTSLLELCGKTIGFIGTGNIAKEAAKRFSGFNVNILGVNTKGREVEYFNKCY
HCCCEEEECHHHHHHHHHHHCEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHC
SKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKSGALFINISRGSIVDERKLIEN
CCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYK
CCCCCCCCCEEEHHCCCCCCCCCCCEECCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHH
EGTELKSVVNMNKGY
CHHHHHHHHHCCCCC
>Mature Secondary Structure 
SIKALFTYNYGKENMKKIENLGYDITIINEKEIKYKDQIKDMEVLVCYNPFSTLDISLM
CEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCHHHCCCCEEEEEEECCCCHHHHHHH
KNLKWIQLSSTGVDQVPKDIVLKNNVIVTNNNGGYSIPIAEWIVLKTLELLKNSKEFYKK
CCCEEEEEECCCHHHCCHHHEEECCEEEECCCCCEECHHHHHHHHHHHHHHHCCHHHHHH
QENKIWKLDTSLLELCGKTIGFIGTGNIAKEAAKRFSGFNVNILGVNTKGREVEYFNKCY
HCCCEEEECHHHHHHHHHHHCEEECCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHC
SKDNIKEMVSKSDIIILSIPYTKETENLVDENVLNSMKSGALFINISRGSIVDERKLIEN
CCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHH
LKLGKIKGAALDVFEEEPLFRDNPIWELDNAIITPHNSWISEKRNIRRFDIIYENLKNYK
CCCCCCCCCEEEHHCCCCCCCCCCCEECCCCEECCCCHHHHHHCCCHHHHHHHHHHHHHH
EGTELKSVVNMNKGY
CHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]