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The map label for this gene is glmU [H]

Identifier: 226951001

GI number: 226951001

Start: 4058982

End: 4060355

Strand: Reverse

Name: glmU [H]

Synonym: CLM_4037

Alternate gene names: 226951001

Gene position: 4060355-4058982 (Counterclockwise)

Preceding gene: 226951002

Following gene: 226951000

Centisome position: 97.72

GC content: 31.22

Gene sequence:

>1374_bases
ATGTATAATTGTGCTATAATATTGGCTGCAGGCAAAGGAAAAAGAATGAAATCTTCTATGCCTAAAGTCGTACACAAGGT
TTGTGGAAAAGAAATGGTAAACCACGTCATTGATAACGTTAGAAAAGCTAATATAAAGGATGTAAACTTGGTAATAGGAA
AAGGATCGAAAACAGTTAAAGAGCATACAAAAGATAGAAATCTTACTTATTCTATGCAAGAAGAACAACTAGGAACTGGC
CATGCTGTTATTTGTGCAGAGGAATTTTTAAAAGATAAAAAAGGTACAGTAGCTATATTTACAGGAGATGCTCCTTTAAT
AACCAATGAAACTATACAACAATTATTTGAATTTCATAATAGTGGGAAATATGCAGCTACTTTAATTTCTTCTACTGTAC
AGGATCCAACAGGATATGGGCGAATTATAAGAGAAGCATCTGGGGAAGTAAAGAAAATAGTTGAACATAAAGATTGTAAT
GAAGAAGAGCTTAAGGTAAATGAAATTAACAGTGGAATGTATTGCTTTGATATAGAAGTTTTATTAAATAGTTTAAAAAA
TCTTAATAATGATAATTCTCAAGGAGAATATTATTTAACAGATGTTATAGAGATAACAAAAAAATCTGGAGATAAAGTTG
GTGCTATAGTTGTACCTTATGAAGAGATCATGGGTGTAAATTCAAGAGTTCAACTTTCAGAAGCAGAGATAGTTATGAGA
AAAAGAATAAATCATAAACATATGGTAAATGGAGTGACATTTATAGACTGTGAAAGTACATATATAGATGTTGATGTAGA
AATAGGAAATGATACTATAATATATCCAGGATGCGTTATCCAGGGAAATACAACAATAAAAGAAGAATGCACGTTATATT
CTAATTCAAGAATATGTAATAGCGTAATAGGATCAGGAGTTATAGTTGAGAATTCTGTCATATTAGAAAGTCATGTGGGA
GAAGGTACTACTGTAGGACCATTTGCTTATATAAGGCCAGAAACTAAAATAGGTAAATCTGCAAGAATAGGGGATTTTGT
GGAAATAAAAAAATCAACTATTGGAGACAACACAAAGGTATCGCACCTTACTTATATAGGGGATGCAGAAGTAGGCAGCA
AGTGCAATTTTGGATGTGGAACTGTAGTAGTAAATTATGATGGACAAAAGAAACAAAAAACTATTATTGGCAACAATGCT
TTTATAGGATGTAACACAAATTTGATTTCACCAGTTAAAGTTAATAACAATACATATATTGCAGCAGGATCTACAATTAC
TAAGGAAGTACCAGAAGGTTCTTTAGCAATTGCTAGATCAAAGCAGATCAATAAAGAAGGCTGGTTAGATAAAAAAGGAT
TATTAAAGAAATAA

Upstream 100 bases:

>100_bases
AATAGGTTGAAAATAATTTTTATATAAAATATAATATTATAAGATGTTTTATTAAATGAAATAAAAGTATATCATAATTA
AACCATAAAGAGGTGCTATA

Downstream 100 bases:

>100_bases
AATTTAAGGAGGACTATATAATGATAACCCATGGAAAAGGTATTAAAATTTTTTCAGGTAATTCTCACCCGAAATTAGCT
CAAGATATTGCTAGTATTTT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MYNCAIILAAGKGKRMKSSMPKVVHKVCGKEMVNHVIDNVRKANIKDVNLVIGKGSKTVKEHTKDRNLTYSMQEEQLGTG
HAVICAEEFLKDKKGTVAIFTGDAPLITNETIQQLFEFHNSGKYAATLISSTVQDPTGYGRIIREASGEVKKIVEHKDCN
EEELKVNEINSGMYCFDIEVLLNSLKNLNNDNSQGEYYLTDVIEITKKSGDKVGAIVVPYEEIMGVNSRVQLSEAEIVMR
KRINHKHMVNGVTFIDCESTYIDVDVEIGNDTIIYPGCVIQGNTTIKEECTLYSNSRICNSVIGSGVIVENSVILESHVG
EGTTVGPFAYIRPETKIGKSARIGDFVEIKKSTIGDNTKVSHLTYIGDAEVGSKCNFGCGTVVVNYDGQKKQKTIIGNNA
FIGCNTNLISPVKVNNNTYIAAGSTITKEVPEGSLAIARSKQINKEGWLDKKGLLKK

Sequences:

>Translated_457_residues
MYNCAIILAAGKGKRMKSSMPKVVHKVCGKEMVNHVIDNVRKANIKDVNLVIGKGSKTVKEHTKDRNLTYSMQEEQLGTG
HAVICAEEFLKDKKGTVAIFTGDAPLITNETIQQLFEFHNSGKYAATLISSTVQDPTGYGRIIREASGEVKKIVEHKDCN
EEELKVNEINSGMYCFDIEVLLNSLKNLNNDNSQGEYYLTDVIEITKKSGDKVGAIVVPYEEIMGVNSRVQLSEAEIVMR
KRINHKHMVNGVTFIDCESTYIDVDVEIGNDTIIYPGCVIQGNTTIKEECTLYSNSRICNSVIGSGVIVENSVILESHVG
EGTTVGPFAYIRPETKIGKSARIGDFVEIKKSTIGDNTKVSHLTYIGDAEVGSKCNFGCGTVVVNYDGQKKQKTIIGNNA
FIGCNTNLISPVKVNNNTYIAAGSTITKEVPEGSLAIARSKQINKEGWLDKKGLLKK
>Mature_457_residues
MYNCAIILAAGKGKRMKSSMPKVVHKVCGKEMVNHVIDNVRKANIKDVNLVIGKGSKTVKEHTKDRNLTYSMQEEQLGTG
HAVICAEEFLKDKKGTVAIFTGDAPLITNETIQQLFEFHNSGKYAATLISSTVQDPTGYGRIIREASGEVKKIVEHKDCN
EEELKVNEINSGMYCFDIEVLLNSLKNLNNDNSQGEYYLTDVIEITKKSGDKVGAIVVPYEEIMGVNSRVQLSEAEIVMR
KRINHKHMVNGVTFIDCESTYIDVDVEIGNDTIIYPGCVIQGNTTIKEECTLYSNSRICNSVIGSGVIVENSVILESHVG
EGTTVGPFAYIRPETKIGKSARIGDFVEIKKSTIGDNTKVSHLTYIGDAEVGSKCNFGCGTVVVNYDGQKKQKTIIGNNA
FIGCNTNLISPVKVNNNTYIAAGSTITKEVPEGSLAIARSKQINKEGWLDKKGLLKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=446, Percent_Identity=41.7040358744395, Blast_Score=340, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6320148, Length=359, Percent_Identity=23.9554317548747, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR001451
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep; PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 50088; Mature: 50088

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNCAIILAAGKGKRMKSSMPKVVHKVCGKEMVNHVIDNVRKANIKDVNLVIGKGSKTVK
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHH
EHTKDRNLTYSMQEEQLGTGHAVICAEEFLKDKKGTVAIFTGDAPLITNETIQQLFEFHN
HHCCCCCCEEEECHHHCCCCCEEEEEHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
SGKYAATLISSTVQDPTGYGRIIREASGEVKKIVEHKDCNEEELKVNEINSGMYCFDIEV
CCCEEEHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCHHHEEEEECCCCEEEEEHHH
LLNSLKNLNNDNSQGEYYLTDVIEITKKSGDKVGAIVVPYEEIMGVNSRVQLSEAEIVMR
HHHHHHCCCCCCCCCCEEEHHHHHHHHCCCCCEEEEEECHHHHHCCCCEEEEHHHHHHHH
KRINHKHMVNGVTFIDCESTYIDVDVEIGNDTIIYPGCVIQGNTTIKEECTLYSNSRICN
HHCCHHHHHCCEEEEECCCEEEEEEEEECCCEEEECCEEEECCCCCHHHEEEECCCHHHH
SVIGSGVIVENSVILESHVGEGTTVGPFAYIRPETKIGKSARIGDFVEIKKSTIGDNTKV
HHHCCCEEEECCEEEEECCCCCCEECCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEE
SHLTYIGDAEVGSKCNFGCGTVVVNYDGQKKQKTIIGNNAFIGCNTNLISPVKVNNNTYI
EEEEEECCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCEECEEEECCCEEE
AAGSTITKEVPEGSLAIARSKQINKEGWLDKKGLLKK
EECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYNCAIILAAGKGKRMKSSMPKVVHKVCGKEMVNHVIDNVRKANIKDVNLVIGKGSKTVK
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHH
EHTKDRNLTYSMQEEQLGTGHAVICAEEFLKDKKGTVAIFTGDAPLITNETIQQLFEFHN
HHCCCCCCEEEECHHHCCCCCEEEEEHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHC
SGKYAATLISSTVQDPTGYGRIIREASGEVKKIVEHKDCNEEELKVNEINSGMYCFDIEV
CCCEEEHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHCCCCHHHEEEEECCCCEEEEEHHH
LLNSLKNLNNDNSQGEYYLTDVIEITKKSGDKVGAIVVPYEEIMGVNSRVQLSEAEIVMR
HHHHHHCCCCCCCCCCEEEHHHHHHHHCCCCCEEEEEECHHHHHCCCCEEEEHHHHHHHH
KRINHKHMVNGVTFIDCESTYIDVDVEIGNDTIIYPGCVIQGNTTIKEECTLYSNSRICN
HHCCHHHHHCCEEEEECCCEEEEEEEEECCCEEEECCEEEECCCCCHHHEEEECCCHHHH
SVIGSGVIVENSVILESHVGEGTTVGPFAYIRPETKIGKSARIGDFVEIKKSTIGDNTKV
HHHCCCEEEECCEEEEECCCCCCEECCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCCEE
SHLTYIGDAEVGSKCNFGCGTVVVNYDGQKKQKTIIGNNAFIGCNTNLISPVKVNNNTYI
EEEEEECCCCCCCCCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCEECEEEECCCEEE
AAGSTITKEVPEGSLAIARSKQINKEGWLDKKGLLKK
EECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA