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The map label for this gene is srrA [H]

Identifier: 226950999

GI number: 226950999

Start: 4057136

End: 4057822

Strand: Reverse

Name: srrA [H]

Synonym: CLM_4035

Alternate gene names: 226950999

Gene position: 4057822-4057136 (Counterclockwise)

Preceding gene: 226951000

Following gene: 226950998

Centisome position: 97.65

GC content: 31.59

Gene sequence:

>687_bases
ATGGAAGGTAAAATAGGAAAAGTTCTCGTTGTAGATGATGATGAAAATATAGCTGAAGTAATAAAAATGTATTTGGAAAA
TTCAGGATACGACACAAGGGTTTGTTATAATGGCAAAGAAGCTCAAGAGGGATTTTTAGAGTATAAACCAGATTTAGTTT
TGCTAGATATAATGCTTCCACATATAGATGGAGTTGATGTGCTTAAATGGATAAGAAAAGACAGCACAATACCTATAATA
ATGTTAACGGCAAAGGGAGATACTTTTGACAAAGTATTAGCTTTAGAGCTCGGGGCAGATGATTATATAGTAAAACCTTT
TGAGCCTAAAGAATTATTAGCAAGAGTTAAGGCTGTACTAAGAAGATATAATGTGGATAATGAAAATAAGGAAGCCTTAA
ATTTTGAACAGCTAACAATAGATGTTAATTCTTATACAGTTGTCTATAAAAATAAGGAAATAAAAATGCCACCAAAAGAA
TTTGAGCTTTTATATTATTTAGCAAGAAATAAAAACAGAGTGTTTACTAGGGAGCAATTATTATGTGAAGTATGGGGATA
TGATTACCCAGGAGATTCAAGAACAGTAGATGTTCACATAAAAAGATTAAGAGAAAAACTAGAAGGAGGACCTAATTGGG
AAATAGAAACTGTTTGGGGTGTAGGTTACAAATTTGAGGTGAAATAA

Upstream 100 bases:

>100_bases
TTGAAGAATTATTTATTTTTATTTTAAATAATATGATAAATTAAATATGTATTATATAGAGATAATATATAATATATAAA
GTTAAAAGGAGGATATACCA

Downstream 100 bases:

>100_bases
ATGAAAAAAGGTTTATTTGCTAAACTTGTAGCTACATTTACCATAATAATATCTGTAAGCTTTATAATTATAGCAACATT
TTTATCTTATTGGTTTGAGA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MEGKIGKVLVVDDDENIAEVIKMYLENSGYDTRVCYNGKEAQEGFLEYKPDLVLLDIMLPHIDGVDVLKWIRKDSTIPII
MLTAKGDTFDKVLALELGADDYIVKPFEPKELLARVKAVLRRYNVDNENKEALNFEQLTIDVNSYTVVYKNKEIKMPPKE
FELLYYLARNKNRVFTREQLLCEVWGYDYPGDSRTVDVHIKRLREKLEGGPNWEIETVWGVGYKFEVK

Sequences:

>Translated_228_residues
MEGKIGKVLVVDDDENIAEVIKMYLENSGYDTRVCYNGKEAQEGFLEYKPDLVLLDIMLPHIDGVDVLKWIRKDSTIPII
MLTAKGDTFDKVLALELGADDYIVKPFEPKELLARVKAVLRRYNVDNENKEALNFEQLTIDVNSYTVVYKNKEIKMPPKE
FELLYYLARNKNRVFTREQLLCEVWGYDYPGDSRTVDVHIKRLREKLEGGPNWEIETVWGVGYKFEVK
>Mature_228_residues
MEGKIGKVLVVDDDENIAEVIKMYLENSGYDTRVCYNGKEAQEGFLEYKPDLVLLDIMLPHIDGVDVLKWIRKDSTIPII
MLTAKGDTFDKVLALELGADDYIVKPFEPKELLARVKAVLRRYNVDNENKEALNFEQLTIDVNSYTVVYKNKEIKMPPKE
FELLYYLARNKNRVFTREQLLCEVWGYDYPGDSRTVDVHIKRLREKLEGGPNWEIETVWGVGYKFEVK

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=42.0353982300885, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=38.1165919282511, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.8017621145374, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=37.3873873873874, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.9775784753363, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=37.719298245614, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=36.7256637168142, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=33.0396475770925, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=34.0909090909091, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=36.9098712446352, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.8035714285714, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=34.0909090909091, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=31.6742081447964, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1787229, Length=208, Percent_Identity=32.2115384615385, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1788550, Length=125, Percent_Identity=35.2, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=34.9206349206349, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=162, Percent_Identity=30.8641975308642, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26535; Mature: 26535

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGKIGKVLVVDDDENIAEVIKMYLENSGYDTRVCYNGKEAQEGFLEYKPDLVLLDIMLP
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCHHHCCHHHCCCCEEEEEEECC
HIDGVDVLKWIRKDSTIPIIMLTAKGDTFDKVLALELGADDYIVKPFEPKELLARVKAVL
CCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHH
RRYNVDNENKEALNFEQLTIDVNSYTVVYKNKEIKMPPKEFELLYYLARNKNRVFTREQL
HHCCCCCCCCCCCCEEEEEEEECCEEEEEECCCCCCCHHHHHEEEEEECCCCCEEHHHHH
LCEVWGYDYPGDSRTVDVHIKRLREKLEGGPNWEIETVWGVGYKFEVK
HHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEEEEEECCEEEEEC
>Mature Secondary Structure
MEGKIGKVLVVDDDENIAEVIKMYLENSGYDTRVCYNGKEAQEGFLEYKPDLVLLDIMLP
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCHHHCCHHHCCCCEEEEEEECC
HIDGVDVLKWIRKDSTIPIIMLTAKGDTFDKVLALELGADDYIVKPFEPKELLARVKAVL
CCCCHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHH
RRYNVDNENKEALNFEQLTIDVNSYTVVYKNKEIKMPPKEFELLYYLARNKNRVFTREQL
HHCCCCCCCCCCCCEEEEEEEECCEEEEEECCCCCCCHHHHHEEEEEECCCCCEEHHHHH
LCEVWGYDYPGDSRTVDVHIKRLREKLEGGPNWEIETVWGVGYKFEVK
HHHHHCCCCCCCCEEEEHHHHHHHHHHCCCCCEEEEEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA