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The map label for this gene is yvtA [H]

Identifier: 226950997

GI number: 226950997

Start: 4054519

End: 4055691

Strand: Reverse

Name: yvtA [H]

Synonym: CLM_4033

Alternate gene names: 226950997

Gene position: 4055691-4054519 (Counterclockwise)

Preceding gene: 226950998

Following gene: 226950996

Centisome position: 97.6

GC content: 31.97

Gene sequence:

>1173_bases
ATGGGTAGAGATAATTTAAATAATATTGAAGAGAATGGTTTAAATGCTGAACCATATGGTGAAATAAATTTTAAAAAGAG
TAGAAAAAGAAGAAGGATGAAAAATATACTATTTATTATGATTATAATTATAGTATCAGCTTTATGTGGTGGAGTAACGG
CTTCCTATATGATAGATAAAAAATTAGAAAAGAATCCATATACACCTACTAATCAGTCCTTATTCGAACAAAAAAGTGAA
AAAAATGAAAAAGAAAATAAAAACGAACAATTGCCTAAAAATTCCGTAACAAAGGTTGCTGAAAGTGTAGGGCCAGCAGT
GGTAGGCATTAGTAATAAAACAGAAGGATATTTTGGAATAGAAGATCGAGGCTCAGGATCAGGTATAATATTCGACCCTA
ATGGATATATTGTAACTAATAATCATGTAATAGAAGGAGCGCAAAAAATAACAGTAAAATTATCTACAGGAAAAGTTCTA
GATGCTTCTTTAGTTGGAAGAGATGTTAGGTCAGATTTAGCTGTTATAAAAGTTAATGCTAAAAATCTACCTGTAGCCAA
ATTTGGTGATTCATCAAAGGTTAAAGTAGGAGATGTGGCTATAGCTATTGGCAATCCTTTAGGAGAAGAATTTGCAGGAA
CTGTTACAGCAGGCATAGTTAGTGCTGTAAATAGAAAGATTCATTATGCAGGGGCTTTGTATAAATTAATACAAACAGAT
GCAGCTATAAATCCAGGAAATAGTGGTGGGGCTTTGTGTAATGATGCAGGAGAAATTATAGGAATTAATAGTTTAAAAGA
AAAAGCAGAAGGAATAGGTTTTGCTATTTCTATAAATGAAGCTAAAGATATAATAAAATCTCTAATGGATTATGGTAAAG
TATCAAGGCCTTATTTGGGCATATCTGGCGAAACTATATCTTCAGAACAAACTAGAGTATCTGGGGTATATGTAACAGAG
GTAGTTCAGGGTTCAGGAGCAGCTGCAGCAGGAATTAAACCTACAGATATAATAGTAGAGTTAGATGGTAAAAAGGTTAC
TAAGTGGGACGATCTGGGAGAGATAGTAGGCAGCCATAAAATTGGAGATACGGTAAAGGTTAAAATATTAAGAAATGATA
AATATAAAGAAGTTAATATAAAATTATCTGAAATGAAGGAAAGTAATAGATAA

Upstream 100 bases:

>100_bases
GATATTTGGGTTAATAATAGTCCAGAAGGAGGGGTAACTTTTAATTTTACCATAAAGAGAGCATAATTATTAAATTTAAA
CTAAAGAGCGGAGGTTGAAC

Downstream 100 bases:

>100_bases
AATATAATATATAATAAATAGTAAAGGGACCTAATAAGTCTCTTTATTATTTATTTATTATAGTATAATATTCTTTAGTG
ATATTAATATTATAATTAGG

Product: putative protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MGRDNLNNIEENGLNAEPYGEINFKKSRKRRRMKNILFIMIIIIVSALCGGVTASYMIDKKLEKNPYTPTNQSLFEQKSE
KNEKENKNEQLPKNSVTKVAESVGPAVVGISNKTEGYFGIEDRGSGSGIIFDPNGYIVTNNHVIEGAQKITVKLSTGKVL
DASLVGRDVRSDLAVIKVNAKNLPVAKFGDSSKVKVGDVAIAIGNPLGEEFAGTVTAGIVSAVNRKIHYAGALYKLIQTD
AAINPGNSGGALCNDAGEIIGINSLKEKAEGIGFAISINEAKDIIKSLMDYGKVSRPYLGISGETISSEQTRVSGVYVTE
VVQGSGAAAAGIKPTDIIVELDGKKVTKWDDLGEIVGSHKIGDTVKVKILRNDKYKEVNIKLSEMKESNR

Sequences:

>Translated_390_residues
MGRDNLNNIEENGLNAEPYGEINFKKSRKRRRMKNILFIMIIIIVSALCGGVTASYMIDKKLEKNPYTPTNQSLFEQKSE
KNEKENKNEQLPKNSVTKVAESVGPAVVGISNKTEGYFGIEDRGSGSGIIFDPNGYIVTNNHVIEGAQKITVKLSTGKVL
DASLVGRDVRSDLAVIKVNAKNLPVAKFGDSSKVKVGDVAIAIGNPLGEEFAGTVTAGIVSAVNRKIHYAGALYKLIQTD
AAINPGNSGGALCNDAGEIIGINSLKEKAEGIGFAISINEAKDIIKSLMDYGKVSRPYLGISGETISSEQTRVSGVYVTE
VVQGSGAAAAGIKPTDIIVELDGKKVTKWDDLGEIVGSHKIGDTVKVKILRNDKYKEVNIKLSEMKESNR
>Mature_389_residues
GRDNLNNIEENGLNAEPYGEINFKKSRKRRRMKNILFIMIIIIVSALCGGVTASYMIDKKLEKNPYTPTNQSLFEQKSEK
NEKENKNEQLPKNSVTKVAESVGPAVVGISNKTEGYFGIEDRGSGSGIIFDPNGYIVTNNHVIEGAQKITVKLSTGKVLD
ASLVGRDVRSDLAVIKVNAKNLPVAKFGDSSKVKVGDVAIAIGNPLGEEFAGTVTAGIVSAVNRKIHYAGALYKLIQTDA
AINPGNSGGALCNDAGEIIGINSLKEKAEGIGFAISINEAKDIIKSLMDYGKVSRPYLGISGETISSEQTRVSGVYVTEV
VQGSGAAAAGIKPTDIIVELDGKKVTKWDDLGEIVGSHKIGDTVKVKILRNDKYKEVNIKLSEMKESNR

Specific function: May be involved in processing, maturation, or secretion of extracellular enzymes [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=286, Percent_Identity=34.6153846153846, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI24308541, Length=301, Percent_Identity=33.5548172757475, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI22129776, Length=294, Percent_Identity=36.3945578231293, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI7019477, Length=295, Percent_Identity=32.2033898305085, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786356, Length=274, Percent_Identity=43.7956204379562, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789629, Length=328, Percent_Identity=39.6341463414634, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1789630, Length=304, Percent_Identity=38.8157894736842, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24646839, Length=282, Percent_Identity=33.6879432624113, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 41888; Mature: 41757

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRDNLNNIEENGLNAEPYGEINFKKSRKRRRMKNILFIMIIIIVSALCGGVTASYMIDK
CCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KLEKNPYTPTNQSLFEQKSEKNEKENKNEQLPKNSVTKVAESVGPAVVGISNKTEGYFGI
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCEECC
EDRGSGSGIIFDPNGYIVTNNHVIEGAQKITVKLSTGKVLDASLVGRDVRSDLAVIKVNA
CCCCCCCEEEECCCCEEEECCEEECCCEEEEEEEECCCEEEHHHHHHHHHCCEEEEEECC
KNLPVAKFGDSSKVKVGDVAIAIGNPLGEEFAGTVTAGIVSAVNRKIHYAGALYKLIQTD
CCCCEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AAINPGNSGGALCNDAGEIIGINSLKEKAEGIGFAISINEAKDIIKSLMDYGKVSRPYLG
CCCCCCCCCCCCCCCCCCEEECHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEC
ISGETISSEQTRVSGVYVTEVVQGSGAAAAGIKPTDIIVELDGKKVTKWDDLGEIVGSHK
CCCCCCCCCCCEECEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCC
IGDTVKVKILRNDKYKEVNIKLSEMKESNR
CCCEEEEEEEECCCEEEEEEEEEHHHCCCC
>Mature Secondary Structure 
GRDNLNNIEENGLNAEPYGEINFKKSRKRRRMKNILFIMIIIIVSALCGGVTASYMIDK
CCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
KLEKNPYTPTNQSLFEQKSEKNEKENKNEQLPKNSVTKVAESVGPAVVGISNKTEGYFGI
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCEECC
EDRGSGSGIIFDPNGYIVTNNHVIEGAQKITVKLSTGKVLDASLVGRDVRSDLAVIKVNA
CCCCCCCEEEECCCCEEEECCEEECCCEEEEEEEECCCEEEHHHHHHHHHCCEEEEEECC
KNLPVAKFGDSSKVKVGDVAIAIGNPLGEEFAGTVTAGIVSAVNRKIHYAGALYKLIQTD
CCCCEEECCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AAINPGNSGGALCNDAGEIIGINSLKEKAEGIGFAISINEAKDIIKSLMDYGKVSRPYLG
CCCCCCCCCCCCCCCCCCEEECHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCEEC
ISGETISSEQTRVSGVYVTEVVQGSGAAAAGIKPTDIIVELDGKKVTKWDDLGEIVGSHK
CCCCCCCCCCCEECEEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCC
IGDTVKVKILRNDKYKEVNIKLSEMKESNR
CCCEEEEEEEECCCEEEEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10692364; 9353931; 9384377; 10568751; 11133960 [H]