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The map label for this gene is prsA [H]

Identifier: 226950994

GI number: 226950994

Start: 4049212

End: 4050222

Strand: Reverse

Name: prsA [H]

Synonym: CLM_4030

Alternate gene names: 226950994

Gene position: 4050222-4049212 (Counterclockwise)

Preceding gene: 226950995

Following gene: 226950993

Centisome position: 97.47

GC content: 27.0

Gene sequence:

>1011_bases
GTGAAAAGTGCAAAAAAATTATTAAGCGTATTGTGTTTAGGAATATTTATTTTAACATTTACAGCATGCGATATGGTGGA
AAAGACTCCAGAAGCTAAAGCCAAAAGTACCATAGCCAAAGTAAATGGTGAAAAGATTCAAAGGAAAGATTTAGATGAAA
GCCCTAGTATGCAACAAGTGCTTAGTCAAATAAAAACACAGTATGGTGAAGAATTTGAAAAAACTGAACAAGGGAAAGAA
GTTATAAAAGAACAAAAGAAGCAAATATTAGAAAATCTCATAACAGAAAAAGTTTTATTACAAAAGGGGAAAGAATTAAA
AGTTATTCCAAAGGATGAGGAATTAAACAAAGAAGCAGATAAAAAAGTTAATGAAATAAAGGCAGTATATAATAATGATG
AAAAGAAATTTGAAGAGACTTTAAAATCTACAGGATTTACTAAAGAAACTCTAAAAGAATACTTAAAAGATCAGATAGTA
ATAGAAAAAGTTATAAATGAAGTTACAAAAGATGTAAAAGTTGAAGATAAGGATGCCCAAAAGTATTATAATGAAAATCA
AAGTATGTTCACAGAAAAACCAAATACTATGAATGTATCACATATATTAGTTAAAACAGAAGATGAAGCTAAAAAAGTTA
AAAAGAGATTAGATGCAAAAGAAGATTTTGCAAAAGTTGCAAAGGAAGTATCACAGGATACAGGTTCTAAAGATAAGGGT
GGATTATTAGGAGATATAAGTTATAGTGATTCTAATTTTGATCCTACATTTATGAAAGCGGCTATAGCTCTTAAATCAGG
TGCAATTTCTAATCCAGTTCATACTCAATTTGGATACCATATTATAAAGATTAATAGTAAAAAAGAATATCCAGTTAAAA
AATTTGATTCTGTAAAAGAAGATATTAAAAAACAATTAAAACAAGAAAAACAACAAGAAGCTTATACCAAAAAAATAGAA
GAATGGAAAAAAGCTTCTAAGATAAAAACTTACGAAAAAAATCTATTATAA

Upstream 100 bases:

>100_bases
TAAACAACAATCAATAAGTAGATATTTTGTAGTATTATTAATTATGTGGTAAAATTACTTTAATTGCGTAAAAAAAATGT
TAAGAGTGGAGGAATATAGG

Downstream 100 bases:

>100_bases
TGAATAAAAATCATGTGTATTAATTACACATGATTTTTATTTGGAAGAAAATTTTAAAAAGTTAGTTTATTTTACAATTA
AATGAAAAAATATAAAATGT

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKTEQGKE
VIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIV
IEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKDKG
GLLGDISYSDSNFDPTFMKAAIALKSGAISNPVHTQFGYHIIKINSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIE
EWKKASKIKTYEKNLL

Sequences:

>Translated_336_residues
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKTEQGKE
VIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIV
IEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKDKG
GLLGDISYSDSNFDPTFMKAAIALKSGAISNPVHTQFGYHIIKINSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIE
EWKKASKIKTYEKNLL
>Mature_336_residues
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQVLSQIKTQYGEEFEKTEQGKE
VIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEADKKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIV
IEKVINEVTKDVKVEDKDAQKYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKDKG
GLLGDISYSDSNFDPTFMKAAIALKSGAISNPVHTQFGYHIIKINSKKEYPVKKFDSVKEDIKKQLKQEKQQEAYTKKIE
EWKKASKIKTYEKNLL

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=385, Percent_Identity=24.4155844155844, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786238, Length=150, Percent_Identity=30.6666666666667, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 38550; Mature: 38550

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHH
LSQIKTQYGEEFEKTEQGKEVIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCHHHH
KKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIVIEKVINEVTKDVKVEDKDAQ
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKDKG
HHHCCCCHHHCCCCCCCCHHEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
GLLGDISYSDSNFDPTFMKAAIALKSGAISNPVHTQFGYHIIKINSKKEYPVKKFDSVKE
CEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCCCCCHHHHHHHHH
DIKKQLKQEKQQEAYTKKIEEWKKASKIKTYEKNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSAKKLLSVLCLGIFILTFTACDMVEKTPEAKAKSTIAKVNGEKIQRKDLDESPSMQQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHCCCCCCCHHHH
LSQIKTQYGEEFEKTEQGKEVIKEQKKQILENLITEKVLLQKGKELKVIPKDEELNKEAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHCHHHH
KKVNEIKAVYNNDEKKFEETLKSTGFTKETLKEYLKDQIVIEKVINEVTKDVKVEDKDAQ
HHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KYYNENQSMFTEKPNTMNVSHILVKTEDEAKKVKKRLDAKEDFAKVAKEVSQDTGSKDKG
HHHCCCCHHHCCCCCCCCHHEEEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
GLLGDISYSDSNFDPTFMKAAIALKSGAISNPVHTQFGYHIIKINSKKEYPVKKFDSVKE
CEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHCCCEEEEEECCCCCCCHHHHHHHHH
DIKKQLKQEKQQEAYTKKIEEWKKASKIKTYEKNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA