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The map label for this gene is thyX [H]

Identifier: 226950953

GI number: 226950953

Start: 3995309

End: 3996061

Strand: Reverse

Name: thyX [H]

Synonym: CLM_3970

Alternate gene names: 226950953

Gene position: 3996061-3995309 (Counterclockwise)

Preceding gene: 226950954

Following gene: 226950952

Centisome position: 96.17

GC content: 29.08

Gene sequence:

>753_bases
ATGAAAGTTAAATTATTAGAATATACACCAAATGCAGAAAAATTAATAGCTTCCGCAGCAAAATTATGTTATAGTTCATC
TGGAATTGAAGATTTACAAAATAATTTAGACAAAGAAAAAGTGGATAAATTTTTAAATATGTTAATGTCCTATGGACATG
AATCACCAATAGAACATGTTTCTTTTACTTTTGGTATAGAGGGAGTATCAAGAAGTTTAACACATCAACTTGTAAGACAT
AGAATAGGATCTTATTCACAACAAAGCCAAAGGTATGTTAGGTTAGATCAATTTGAATATGTTATTCCACCTTCTGTAGA
AAAGGATGAAGAGGCAAAAAATATATATATAGAAACTATGAAAAATTGTCAAAAGTCCTACGATGATATTGCGAGTATTT
TAAAAGAAAAATATATTAATAATGGATTAAGGGATATAGATGCAGAAAAAAAGGCTATAGAAGATGCAAGATATGTATTT
CCAAATGCTTGTACAAGTAAAATTATAGTTACAATGAATGCTAGAAGTTTAATGAATTTCTTTAGACATAGATGCTGCAA
TAGAGCGCAATGGGAAATAAGAGAACTAGCTGAAATTATGTTGTTTGAAGTTAAAGATGTTGCACCAACATTATTTAAAT
ATTGTGGACCAGGTTGCGTAAATGGACCTTGTCCAGAAGGAAAAATGTCCTGTGGTAAAATAAAAGAAGTTAGAGAAAAG
TACAATGTAAAATTATACAAGGAGAGTAAGTAA

Upstream 100 bases:

>100_bases
GCCCTTATAGGTTTTTTATATATAACAGATCAACAGGAAAGATTAAATTATTTATTAAATAATATAGTTACTTTAAATGG
GAAAAAAGGAGCACTTGATA

Downstream 100 bases:

>100_bases
TAATGAAAAATAGAGTTGGTCAACAGGAAGAAATAAGAGAAGATATAATAGAGGGCAGAAATGCGGTAATAGAAGCATTA
AAATCAAATAAAACTATAGA

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKVKLLEYTPNAEKLIASAAKLCYSSSGIEDLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLVRH
RIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIETMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVF
PNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVREK
YNVKLYKESK

Sequences:

>Translated_250_residues
MKVKLLEYTPNAEKLIASAAKLCYSSSGIEDLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLVRH
RIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIETMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVF
PNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVREK
YNVKLYKESK
>Mature_250_residues
MKVKLLEYTPNAEKLIASAAKLCYSSSGIEDLQNNLDKEKVDKFLNMLMSYGHESPIEHVSFTFGIEGVSRSLTHQLVRH
RIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIETMKNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVF
PNACTSKIIVTMNARSLMNFFRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVREK
YNVKLYKESK

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 28827; Mature: 28827

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKLLEYTPNAEKLIASAAKLCYSSSGIEDLQNNLDKEKVDKFLNMLMSYGHESPIEHV
CCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
SFTFGIEGVSRSLTHQLVRHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIETM
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHH
KNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVFPNACTSKIIVTMNARSLMNF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHH
FRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVREK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
YNVKLYKESK
HCCCEEECCC
>Mature Secondary Structure
MKVKLLEYTPNAEKLIASAAKLCYSSSGIEDLQNNLDKEKVDKFLNMLMSYGHESPIEHV
CCEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHH
SFTFGIEGVSRSLTHQLVRHRIGSYSQQSQRYVRLDQFEYVIPPSVEKDEEAKNIYIETM
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHH
KNCQKSYDDIASILKEKYINNGLRDIDAEKKAIEDARYVFPNACTSKIIVTMNARSLMNF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHH
FRHRCCNRAQWEIRELAEIMLFEVKDVAPTLFKYCGPGCVNGPCPEGKMSCGKIKEVREK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
YNVKLYKESK
HCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]