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The map label for this gene is vanR [H]

Identifier: 226950786

GI number: 226950786

Start: 3837233

End: 3837925

Strand: Reverse

Name: vanR [H]

Synonym: CLM_3797

Alternate gene names: 226950786

Gene position: 3837925-3837233 (Counterclockwise)

Preceding gene: 226950787

Following gene: 226950785

Centisome position: 92.36

GC content: 28.72

Gene sequence:

>693_bases
GTGAGTTATAAAATATTAATAGTAGATGATGACAAGACCATAGTAGAATTTTTACAAATATTTTTAATTAAAGAGGGGTA
TGAGGTAAGGATTTCTTATAACGGAGAAGAGGCTTTAGATAAAATAAGAAGTGAACAATTTAATTTGATTCTAATGGATA
TAATGATGCCTAAATTAGATGGATTTGGAGCTATTAAAGGAATAAAGAAACTTACAAATATTCCTATTATATTTTTAACT
GCAAAGGATAGTCAGCAAGATAAAATTAAAGGCTTTATTTCTGGATGTGACGATTATATAACAAAGCCCTTTGATTTAGT
AGAACTTTCTTTAAGAGTGTCCGCTATACTTAAAAGAGTTAGCACAAGTGTAGTTGAAGAAAATGAGGATATTATAAAAG
TGAAGGATTTAGAATTAAATTTAAAGGAGCATACACTATATAAAGAAAAAAATGAAATAAAGCTTACGCCAAAGGAATTT
GACATTTTATTTTTGCTTGCTAGAAATAAGGGGAGAATTTTTCCTTCAAGTGAGATATATGAAAGGGTATGGGGACAAGA
ATTTTTAGAAAATGACAATAGCTTGTTGACCCATATTAGAAATTTAAGAGAAAAGCTAAGTGATACTGTAAAAAACTCAA
AATACATTAAAACTGTTTGGGGAGTGGGTTATAAGATTGAAAAGGAAGCTTAG

Upstream 100 bases:

>100_bases
TGATGCATTTAAAATAACTTATTTGGCACAGAGGTATATTTTTTTCTAGTACAAAGTGTTATTTGGTATAATTATATAGG
ATATGTAAGGGGGGTGCTAA

Downstream 100 bases:

>100_bases
AATTGGATTAACAACAGAACTGATGCTACTTTTTGTTATATCTTTAATAATTACAATTTTTGGAATGATGATGGTTTTAG
GGAGTCTAAATATTTCATCG

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFGAIKGIKKLTNIPIIFLT
AKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVVEENEDIIKVKDLELNLKEHTLYKEKNEIKLTPKEF
DILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA

Sequences:

>Translated_230_residues
MSYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFGAIKGIKKLTNIPIIFLT
AKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVVEENEDIIKVKDLELNLKEHTLYKEKNEIKLTPKEF
DILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
>Mature_229_residues
SYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLDGFGAIKGIKKLTNIPIIFLTA
KDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRVSTSVVEENEDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFD
ILFLLARNKGRIFPSSEIYERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.15859030837, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=30.2631578947368, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=32.4324324324324, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=35.1111111111111, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=28.9592760180996, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=32.4444444444444, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=29.9559471365639, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=31.6964285714286, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.7610619469027, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=29.1479820627803, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.9734513274336, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=30.1310043668122, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=26.2222222222222, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790437, Length=102, Percent_Identity=37.2549019607843, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693140, Length=245, Percent_Identity=27.3469387755102, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=35.3448275862069, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790299, Length=137, Percent_Identity=29.1970802919708, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788905, Length=160, Percent_Identity=28.75, Blast_Score=60, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6323034, Length=139, Percent_Identity=31.6546762589928, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=103, Percent_Identity=33.9805825242718, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26717; Mature: 26586

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLD
CCEEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCEEEEEHHHHCCC
GFGAIKGIKKLTNIPIIFLTAKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRV
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHH
STSVVEENEDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFDILFLLARNKGRIFPSSEIY
HHHHHHCCCCEEEEEEEEECHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCHHHH
ERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCC
>Mature Secondary Structure 
SYKILIVDDDKTIVEFLQIFLIKEGYEVRISYNGEEALDKIRSEQFNLILMDIMMPKLD
CEEEEEEECCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCEEEEEHHHHCCC
GFGAIKGIKKLTNIPIIFLTAKDSQQDKIKGFISGCDDYITKPFDLVELSLRVSAILKRV
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHH
STSVVEENEDIIKVKDLELNLKEHTLYKEKNEIKLTPKEFDILFLLARNKGRIFPSSEIY
HHHHHHCCCCEEEEEEEEECHHHHHHHCCCCCEEECCCCEEEEEEEECCCCCCCCCHHHH
ERVWGQEFLENDNSLLTHIRNLREKLSDTVKNSKYIKTVWGVGYKIEKEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]