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The map label for this gene is mmgC [H]

Identifier: 226950713

GI number: 226950713

Start: 3736220

End: 3737353

Strand: Reverse

Name: mmgC [H]

Synonym: CLM_3721

Alternate gene names: 226950713

Gene position: 3737353-3736220 (Counterclockwise)

Preceding gene: 226950714

Following gene: 226950712

Centisome position: 89.94

GC content: 33.16

Gene sequence:

>1134_bases
ATGTTTTTCACAGAACAACATGAACTTATTAGAAAATTAGCAAGAGATTTTGCAGAGCAGAAAATAGAACCTATTGCAGA
TGAAGTAGATAAAACTGCCGAGTTCCCTAAAGAAATTGTGAAAAAAATGGCCCAAAATGGTTTCTTTGGAATAAAAATGC
CTAAAGAATATGGTGGAGCTGGAGCAGATAATAGAGCCTATGTAACTATAATGGAAGAGATATCAAGAGCATCTGGTGTA
GCTGGTATATATTTATCATCACCAAATTCATTGCTTGGCACACCATTCTTACTAGTTGGTACAGATGAACAAAAGGAAAA
ATATTTAAAACCAATGATTAGAGGAGAAAAAACATTAGCTTTTGCTTTAACAGAACCAGGTGCAGGTTCAGACGCAGGAG
CACTTGCAACAACTGCTAGAGAAGAAGGAGACTATTATATATTAAATGGAAGAAAAACTTTTATTACAGGAGCGCCAATA
TCTGATAATATCATAGTGTTTGCAAAAACAGATATGAGCAAAGGAACAAAAGGAATTACTACATTTATAGTAGATAGTAA
ACAAGAGGGAGTGTCTTTTGGTAAACCTGAAGACAAGATGGGAATGATTGGTTGCCCTACCAGTGATATTATTCTAGAAA
ATGTAAAGGTTCATAAATCTGATATACTTGGAGAAGTAAATAAAGGCTTTATAACAGCAATGAAGACTTTAAGTGTTGGT
CGTATAGGAGTTGCTTCTCAAGCTTTAGGAATAGCACAAGCTGCTGTAGATGAAGCTGTTAAATATGCAAAACAAAGAAA
GCAATTTAATAGACCTATAGCAAAATTCCAAGCTATTCAATTTAAATTGGCTAACATGGAAACAAAATTAAATGCGGCAA
AATTATTAGTGTATAATGCTGCTTATAAAATGGATTGTGGAGAAAAGGCAGATAAAGAAGCTTCTATGGCAAAATATTTT
GCTGCTGAATCTGCTATACAAATCGTAAATGACGCACTACAAATCCATGGTGGTTATGGATACATAAAAGATTATAAAAT
AGAAAGATTATATAGAGATGTTAGAGTAATTGCTATATATGAAGGAACTTCTGAAGTTCAACAAATGGTAATCGCATCAA
ATCTTTTAAAGTAA

Upstream 100 bases:

>100_bases
AAATAATATTTATTTTTCAAAAAAGTTATCTTTGGATAGATGAAGGGAAATCGATGTTTATATAAATTAACAAATTCATT
AATATATTAGGAGGGATATA

Downstream 100 bases:

>100_bases
GGAGTGGAGAAATTGAAGATAGTTGTATGTGTAAAACAAGTACCAGATACTAATGAAGTAAAGATCGATCCTGTAAAAGG
AACTCTTATTCGTGAAGGTG

Product: acyl-CoA dehydrogenase family protein

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MFFTEQHELIRKLARDFAEQKIEPIADEVDKTAEFPKEIVKKMAQNGFFGIKMPKEYGGAGADNRAYVTIMEEISRASGV
AGIYLSSPNSLLGTPFLLVGTDEQKEKYLKPMIRGEKTLAFALTEPGAGSDAGALATTAREEGDYYILNGRKTFITGAPI
SDNIIVFAKTDMSKGTKGITTFIVDSKQEGVSFGKPEDKMGMIGCPTSDIILENVKVHKSDILGEVNKGFITAMKTLSVG
RIGVASQALGIAQAAVDEAVKYAKQRKQFNRPIAKFQAIQFKLANMETKLNAAKLLVYNAAYKMDCGEKADKEASMAKYF
AAESAIQIVNDALQIHGGYGYIKDYKIERLYRDVRVIAIYEGTSEVQQMVIASNLLK

Sequences:

>Translated_377_residues
MFFTEQHELIRKLARDFAEQKIEPIADEVDKTAEFPKEIVKKMAQNGFFGIKMPKEYGGAGADNRAYVTIMEEISRASGV
AGIYLSSPNSLLGTPFLLVGTDEQKEKYLKPMIRGEKTLAFALTEPGAGSDAGALATTAREEGDYYILNGRKTFITGAPI
SDNIIVFAKTDMSKGTKGITTFIVDSKQEGVSFGKPEDKMGMIGCPTSDIILENVKVHKSDILGEVNKGFITAMKTLSVG
RIGVASQALGIAQAAVDEAVKYAKQRKQFNRPIAKFQAIQFKLANMETKLNAAKLLVYNAAYKMDCGEKADKEASMAKYF
AAESAIQIVNDALQIHGGYGYIKDYKIERLYRDVRVIAIYEGTSEVQQMVIASNLLK
>Mature_377_residues
MFFTEQHELIRKLARDFAEQKIEPIADEVDKTAEFPKEIVKKMAQNGFFGIKMPKEYGGAGADNRAYVTIMEEISRASGV
AGIYLSSPNSLLGTPFLLVGTDEQKEKYLKPMIRGEKTLAFALTEPGAGSDAGALATTAREEGDYYILNGRKTFITGAPI
SDNIIVFAKTDMSKGTKGITTFIVDSKQEGVSFGKPEDKMGMIGCPTSDIILENVKVHKSDILGEVNKGFITAMKTLSVG
RIGVASQALGIAQAAVDEAVKYAKQRKQFNRPIAKFQAIQFKLANMETKLNAAKLLVYNAAYKMDCGEKADKEASMAKYF
AAESAIQIVNDALQIHGGYGYIKDYKIERLYRDVRVIAIYEGTSEVQQMVIASNLLK

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=48.2666666666667, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=39.9463806970509, Blast_Score=298, Evalue=4e-81,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=39.5778364116095, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=38.3378016085791, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI226958414, Length=356, Percent_Identity=38.4831460674157, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=37.9679144385027, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=37.9679144385027, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=39.943342776204, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=32.4468085106383, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI76496475, Length=373, Percent_Identity=34.8525469168901, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI4557235, Length=373, Percent_Identity=34.8525469168901, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI4503943, Length=372, Percent_Identity=28.494623655914, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI7669494, Length=362, Percent_Identity=28.7292817679558, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI48976061, Length=396, Percent_Identity=27.020202020202, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI211971008, Length=396, Percent_Identity=27.020202020202, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI38505218, Length=388, Percent_Identity=27.0618556701031, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=33.7730870712401, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1786223, Length=374, Percent_Identity=32.8877005347594, Blast_Score=198, Evalue=5e-52,
Organism=Escherichia coli, GI87081702, Length=364, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=24.5674740484429, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=39.7297297297297, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=38.4210526315789, Blast_Score=263, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=36.5333333333333, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=39.3139841688654, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17533517, Length=372, Percent_Identity=38.1720430107527, Blast_Score=251, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=37.3015873015873, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=37.9947229551451, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=42.5170068027211, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.8571428571429, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=35.7142857142857, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI32563615, Length=234, Percent_Identity=38.4615384615385, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=32.0954907161804, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=32, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=28.2258064516129, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=36.9747899159664, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=34.2657342657343, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17562446, Length=329, Percent_Identity=28.8753799392097, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=33.5227272727273, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=266, Percent_Identity=27.0676691729323, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=27.0676691729323, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540912, Length=371, Percent_Identity=23.4501347708895, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=45.0666666666667, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=41.8666666666667, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=36.7021276595745, Blast_Score=268, Evalue=3e-72,
Organism=Drosophila melanogaster, GI21355753, Length=380, Percent_Identity=37.6315789473684, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24660351, Length=377, Percent_Identity=37.4005305039788, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=34.5646437994723, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI19920834, Length=373, Percent_Identity=30.5630026809651, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41343; Mature: 41343

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFTEQHELIRKLARDFAEQKIEPIADEVDKTAEFPKEIVKKMAQNGFFGIKMPKEYGGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHCCC
GADNRAYVTIMEEISRASGVAGIYLSSPNSLLGTPFLLVGTDEQKEKYLKPMIRGEKTLA
CCCCCEEEHHHHHHHHHCCCEEEEEECCCCHHCCCEEEEECCHHHHHHHHHHHCCCCEEE
FALTEPGAGSDAGALATTAREEGDYYILNGRKTFITGAPISDNIIVFAKTDMSKGTKGIT
EEEECCCCCCCCCHHHHHHHCCCCEEEECCCEEEEECCCCCCCEEEEEECCCCCCCCCEE
TFIVDSKQEGVSFGKPEDKMGMIGCPTSDIILENVKVHKSDILGEVNKGFITAMKTLSVG
EEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHCCC
RIGVASQALGIAQAAVDEAVKYAKQRKQFNRPIAKFQAIQFKLANMETKLNAAKLLVYNA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCHHHCCCEEEEEEEC
AYKMDCGEKADKEASMAKYFAAESAIQIVNDALQIHGGYGYIKDYKIERLYRDVRVIAIY
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEEE
EGTSEVQQMVIASNLLK
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFFTEQHELIRKLARDFAEQKIEPIADEVDKTAEFPKEIVKKMAQNGFFGIKMPKEYGGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHCCC
GADNRAYVTIMEEISRASGVAGIYLSSPNSLLGTPFLLVGTDEQKEKYLKPMIRGEKTLA
CCCCCEEEHHHHHHHHHCCCEEEEEECCCCHHCCCEEEEECCHHHHHHHHHHHCCCCEEE
FALTEPGAGSDAGALATTAREEGDYYILNGRKTFITGAPISDNIIVFAKTDMSKGTKGIT
EEEECCCCCCCCCHHHHHHHCCCCEEEECCCEEEEECCCCCCCEEEEEECCCCCCCCCEE
TFIVDSKQEGVSFGKPEDKMGMIGCPTSDIILENVKVHKSDILGEVNKGFITAMKTLSVG
EEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHCCC
RIGVASQALGIAQAAVDEAVKYAKQRKQFNRPIAKFQAIQFKLANMETKLNAAKLLVYNA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCHHHCCCEEEEEEEC
AYKMDCGEKADKEASMAKYFAAESAIQIVNDALQIHGGYGYIKDYKIERLYRDVRVIAIY
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEEEEE
EGTSEVQQMVIASNLLK
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]