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The map label for this gene is pyrC [H]

Identifier: 226950667

GI number: 226950667

Start: 3690736

End: 3691926

Strand: Reverse

Name: pyrC [H]

Synonym: CLM_3651

Alternate gene names: 226950667

Gene position: 3691926-3690736 (Counterclockwise)

Preceding gene: 226950668

Following gene: 226950666

Centisome position: 88.85

GC content: 29.89

Gene sequence:

>1191_bases
ATGAATGAATTACTAATTAGAAATGTTAATATAATAGATTGGTGTCAAAACTTCCATGGAGATGTTTATATAAAAAACGG
AATTATAGAAGAACTAGGAAAAGATTTAAATAAAAATTGTGAAATATTTGATGGAAGAGGATTAACTCTTCTTCCATCTT
TCATAGATATGCATGCCCACTTTAGAGAGCCAGGTTTTACATATAAAGAAGATATATTAACAGGAAGCAAAGCTGCAGTA
AAGGGTGGGTATACTATGGTAAATTTGATGGCCAATACTAAGCCTATATGTAGCTCTAATAAAGAAGTAGAGTATGTTTT
AGAAAAAGGAAAAGAGATAGGTTTAGTAGATATCCACCAATGTATGTCCATTACAAAAGATTTTTCTGGAGATGATATAA
GTCATTTAGATTCTATAGATAAGAAAGTAAAAATAATATCAGAAGATGGAAAAGATGTAATGAATACAAGGGTATTAATA
GAGGCTATGTTTAAAGCTAAAGAAAAAGATCTTATAGTAATGTGCCACTCAGAAGAGCATGATGTAACAAATTTGGATAC
TAGGCTTTCAGAAAATTTAATGACTTGGAGAAACATAGCACTTTCAGAATTTACAGACTGTAAGGTTCATATAGCGCATG
TAAGCACTAAAGAATCTATGGAATATATAAAGGATGCGAAAAAGAAAGGTTTAAAAGTAACTTGTGAAGTAGCACCACAT
CATATAGCACTTACAAATAAAATTTTTTATAGAGTAAATCCACCTTTAAGAGAAGAAGAAGATATAAAGGTATTAATAGA
GGCAATAAAGGAAGATTTAGTAGATTGTATAGGGACGGATCATGCACCTCATAGTAAAGAAGATAAGCTAAAGGGAAGTC
CGGGGATATCAGGAATAGAAACCTCTTTTTCTACATGTTATACAAAGTTAGTTCATAATAATCATATTAGCTTAAGCAAA
CTTTCAAAAATAATGTCTAAAAATCCAGCAGATATTTTAGGTGCAAATAAGGGAGAAATAAAAATAGGAAGAGAAGCAGA
TTTAGTTTTAGTAGATACAAAAGAAGAATATAAAGTAAAATCTGAAGAGTTTCATTCAAAAGGAAAGAATACTCCTATGG
ATGGTATGTATCTTAAAGGAAGAGTTAAAGTTACATTTAAAGCAGGATGTATAGTATATAGTGAATTTTAA

Upstream 100 bases:

>100_bases
AGTAGATGAAGAAAATGGTGAATATAGATGTAAATATTGTGATGAAATATATTCAGGGGGAGATATAAATAAATTATAAA
ATTTATGGAGGTGTACACAA

Downstream 100 bases:

>100_bases
TAGAAAAAGAAAGGATGAATAAATTGATTATAGATAAATTGTATGAAAACGTAGAGAAAAAAGGATGTGTTTGTGTAGGC
CTTGATACGGATATAAGTTA

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNELLIRNVNIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFREPGFTYKEDILTGSKAAV
KGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLI
EAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTDCKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLSK
LSKIMSKNPADILGANKGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMYLKGRVKVTFKAGCIVYSEF

Sequences:

>Translated_396_residues
MNELLIRNVNIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFREPGFTYKEDILTGSKAAV
KGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLI
EAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTDCKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLSK
LSKIMSKNPADILGANKGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMYLKGRVKVTFKAGCIVYSEF
>Mature_396_residues
MNELLIRNVNIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFREPGFTYKEDILTGSKAAV
KGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLI
EAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTDCKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLSK
LSKIMSKNPADILGANKGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMYLKGRVKVTFKAGCIVYSEF

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=28.4237726098191, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI4503379, Length=449, Percent_Identity=24.2761692650334, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI4503375, Length=453, Percent_Identity=23.841059602649, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4503051, Length=450, Percent_Identity=23.1111111111111, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=23.1111111111111, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI19923821, Length=451, Percent_Identity=24.1685144124169, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1786722, Length=432, Percent_Identity=27.3148148148148, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=21.0290827740492, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193204318, Length=365, Percent_Identity=27.6712328767123, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71989490, Length=442, Percent_Identity=23.7556561085973, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=391, Percent_Identity=24.8081841432225, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24642586, Length=348, Percent_Identity=31.3218390804598, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI18859883, Length=211, Percent_Identity=27.0142180094787, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44614; Mature: 44614

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELLIRNVNIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAH
CCCEEEECCCHHHHHHCCCCCEEEECCHHHHHHHHHCCCCEEECCCCCEECHHHHHHHHH
FREPGFTYKEDILTGSKAAVKGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQ
HCCCCCCCHHHHCCCCCHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCEEEHHH
CMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLIEAMFKAKEKDLIVMCHSEEH
HHHHHCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DVTNLDTRLSENLMTWRNIALSEFTDCKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCC
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIE
EEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TSFSTCYTKLVHNNHISLSKLSKIMSKNPADILGANKGEIKIGREADLVLVDTKEEYKVK
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHCCCCCCEEECCCCCEEEEECHHHHHCC
SEEFHSKGKNTPMDGMYLKGRVKVTFKAGCIVYSEF
HHHHHHCCCCCCCCCEEEEEEEEEEEEECEEEEECC
>Mature Secondary Structure
MNELLIRNVNIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAH
CCCEEEECCCHHHHHHCCCCCEEEECCHHHHHHHHHCCCCEEECCCCCEECHHHHHHHHH
FREPGFTYKEDILTGSKAAVKGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQ
HCCCCCCCHHHHCCCCCHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCEEEHHH
CMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLIEAMFKAKEKDLIVMCHSEEH
HHHHHCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DVTNLDTRLSENLMTWRNIALSEFTDCKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
CCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCC
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIE
EEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TSFSTCYTKLVHNNHISLSKLSKIMSKNPADILGANKGEIKIGREADLVLVDTKEEYKVK
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHCCCCCCEEECCCCCEEEEECHHHHHCC
SEEFHSKGKNTPMDGMYLKGRVKVTFKAGCIVYSEF
HHHHHHCCCCCCCCCEEEEEEEEEEEEECEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA