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The map label for this gene is uvrC [H]

Identifier: 226950632

GI number: 226950632

Start: 3654306

End: 3655403

Strand: Reverse

Name: uvrC [H]

Synonym: CLM_3616

Alternate gene names: 226950632

Gene position: 3655403-3654306 (Counterclockwise)

Preceding gene: 226950633

Following gene: 226950631

Centisome position: 87.97

GC content: 20.13

Gene sequence:

>1098_bases
TTGAATTTAAAAGATAAAGCTAAACTATTGCCACAATCACCGGGAATATACATTATGAGAGATTCCTTAAGTAATATAAT
ATATGTTGGCAAATCTAAAAATTTAAGAAAAAGAGTATGCAGTTATTTTATAAAACAAAATAATGCCACTTCTAAAATTG
AAAAACTAATAAAAAATATTAAAGATTTTCAATATATATGTACAGACACAGAATTGGAAGCTTTATTACTGGAGTGTACT
TTTATAAAATGTATAAAGCCCCAATATAATAGATTGATGAAAAATCATGAAAGGTATATTTATATACAAATAAATATTAA
AGATCAATATCCTATAATTAAAGTAGCTTCGGAAATAAAAGATGATAATTACTTATATTATGGGCCTTTTATAAACTATA
ATAGGATTTTGAAATTCGTAGAAGGTTTAAATGAAATCTTACCTTTAATAAAATGTAATAATTATTTAAAGCATAAATCA
ACCTGTATAAACTATGCTATAGGAAAATGCAAAGGACCTTGTATTGAAAATATAAGTTCTAAGCATTATAAGAAATATAT
AGATAAAGTTATAAGTTTTTTTAATGGGGAAAAAGATTTAATTATTTTATTAGAAAAATATATGAGAGAATATTGTGAGA
CTCTAGAATTTGAAAAAGCTAAATTATTTAAAGATTATATAGATGTATTTAATAGTGTATTTCAAGAATATAAACATATT
GTTCGATTAAATAATTATAATAAATTTATTATAGTTGATATTACAAGAAAGAATATATCCAAGGTGATTTTTATAAATAA
TCATAATATAGAGTACATTGATACTATAAATATAGATATTATGTCTAAAAAAAATTTAGAAGAATATTTTAAGGATATAT
ATTTAAGGTTTTATTTAATAAGTCATAATAAAGAATCAAAAAATATTGTAAGTAAAGAATTTATAGATTATGTGCATATA
ATATTTTCATATATAAATATGAAAAAGGAAGATATAGTATATAGTAATATAGAACAAGATGATAATGTTTGTGATTTAGA
GGAAAAATCCTTAAAGTGGTCTAATTATATAATTGATAAATTAAATAAATTTATATAA

Upstream 100 bases:

>100_bases
ATATCATTTTAGATAAATAGTTGTAGATTAAATAAATTGTATTTACCTGTAGTTATATATTATAATATTAATTAATTTAT
CTATATATGGAGTTGGTATA

Downstream 100 bases:

>100_bases
AATATTATTAATAAAATAATAAATAGGATTAGGGGAGAAGAAGATGCCAATAGTTATAGGTAAAGAAAAAGATGATGATG
ATAGGCTCTATGTAACTTTT

Product: GIY-YIG domain-containing protein

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNLKDKAKLLPQSPGIYIMRDSLSNIIYVGKSKNLRKRVCSYFIKQNNATSKIEKLIKNIKDFQYICTDTELEALLLECT
FIKCIKPQYNRLMKNHERYIYIQINIKDQYPIIKVASEIKDDNYLYYGPFINYNRILKFVEGLNEILPLIKCNNYLKHKS
TCINYAIGKCKGPCIENISSKHYKKYIDKVISFFNGEKDLIILLEKYMREYCETLEFEKAKLFKDYIDVFNSVFQEYKHI
VRLNNYNKFIIVDITRKNISKVIFINNHNIEYIDTINIDIMSKKNLEEYFKDIYLRFYLISHNKESKNIVSKEFIDYVHI
IFSYINMKKEDIVYSNIEQDDNVCDLEEKSLKWSNYIIDKLNKFI

Sequences:

>Translated_365_residues
MNLKDKAKLLPQSPGIYIMRDSLSNIIYVGKSKNLRKRVCSYFIKQNNATSKIEKLIKNIKDFQYICTDTELEALLLECT
FIKCIKPQYNRLMKNHERYIYIQINIKDQYPIIKVASEIKDDNYLYYGPFINYNRILKFVEGLNEILPLIKCNNYLKHKS
TCINYAIGKCKGPCIENISSKHYKKYIDKVISFFNGEKDLIILLEKYMREYCETLEFEKAKLFKDYIDVFNSVFQEYKHI
VRLNNYNKFIIVDITRKNISKVIFINNHNIEYIDTINIDIMSKKNLEEYFKDIYLRFYLISHNKESKNIVSKEFIDYVHI
IFSYINMKKEDIVYSNIEQDDNVCDLEEKSLKWSNYIIDKLNKFI
>Mature_365_residues
MNLKDKAKLLPQSPGIYIMRDSLSNIIYVGKSKNLRKRVCSYFIKQNNATSKIEKLIKNIKDFQYICTDTELEALLLECT
FIKCIKPQYNRLMKNHERYIYIQINIKDQYPIIKVASEIKDDNYLYYGPFINYNRILKFVEGLNEILPLIKCNNYLKHKS
TCINYAIGKCKGPCIENISSKHYKKYIDKVISFFNGEKDLIILLEKYMREYCETLEFEKAKLFKDYIDVFNSVFQEYKHI
VRLNNYNKFIIVDITRKNISKVIFINNHNIEYIDTINIDIMSKKNLEEYFKDIYLRFYLISHNKESKNIVSKEFIDYVHI
IFSYINMKKEDIVYSNIEQDDNVCDLEEKSLKWSNYIIDKLNKFI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=230, Percent_Identity=34.7826086956522, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 43779; Mature: 43779

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKDKAKLLPQSPGIYIMRDSLSNIIYVGKSKNLRKRVCSYFIKQNNATSKIEKLIKNI
CCCCCHHHCCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
KDFQYICTDTELEALLLECTFIKCIKPQYNRLMKNHERYIYIQINIKDQYPIIKVASEIK
HHHEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCC
DDNYLYYGPFINYNRILKFVEGLNEILPLIKCNNYLKHKSTCINYAIGKCKGPCIENISS
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
KHYKKYIDKVISFFNGEKDLIILLEKYMREYCETLEFEKAKLFKDYIDVFNSVFQEYKHI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLNNYNKFIIVDITRKNISKVIFINNHNIEYIDTINIDIMSKKNLEEYFKDIYLRFYLI
HEECCCCEEEEEEEECCCCCEEEEEECCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEE
SHNKESKNIVSKEFIDYVHIIFSYINMKKEDIVYSNIEQDDNVCDLEEKSLKWSNYIIDK
ECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCHHHCCHHHHHHHHH
LNKFI
HHHCC
>Mature Secondary Structure
MNLKDKAKLLPQSPGIYIMRDSLSNIIYVGKSKNLRKRVCSYFIKQNNATSKIEKLIKNI
CCCCCHHHCCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
KDFQYICTDTELEALLLECTFIKCIKPQYNRLMKNHERYIYIQINIKDQYPIIKVASEIK
HHHEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHCC
DDNYLYYGPFINYNRILKFVEGLNEILPLIKCNNYLKHKSTCINYAIGKCKGPCIENISS
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
KHYKKYIDKVISFFNGEKDLIILLEKYMREYCETLEFEKAKLFKDYIDVFNSVFQEYKHI
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLNNYNKFIIVDITRKNISKVIFINNHNIEYIDTINIDIMSKKNLEEYFKDIYLRFYLI
HEECCCCEEEEEEEECCCCCEEEEEECCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEE
SHNKESKNIVSKEFIDYVHIIFSYINMKKEDIVYSNIEQDDNVCDLEEKSLKWSNYIIDK
ECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCCHHHCCHHHHHHHHH
LNKFI
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA