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The map label for this gene is bcd [H]

Identifier: 226950627

GI number: 226950627

Start: 3649460

End: 3650599

Strand: Reverse

Name: bcd [H]

Synonym: CLM_3611

Alternate gene names: 226950627

Gene position: 3650599-3649460 (Counterclockwise)

Preceding gene: 226950628

Following gene: 226950626

Centisome position: 87.85

GC content: 33.25

Gene sequence:

>1140_bases
ATGGAATTTGGTTTATCACAAGAACAAAAGCTTGTTAAGCAGATGCTAATGGAATTTGTAGAAAATGAAGTGGAACCAAT
AGCTGCTGATATAGATAAAACAGAGAGATATCCAATTGAAACAGTAGAAAAAATGGCTAAGTATGGAATAATGGGAATGC
CATTTCCAAAGGAATACGGTGGAGCTGGTACTGATTATTTAAGCTATGTTATAGCAGTAGAAGAACTTGCAAAAGAATGT
GCAACTACATCTGTTATTTTATCGGCACATACATCTTTATGTTGCGCTCCAATATTTGAATTTGGGACAGAAGAGCAAAA
GAAAAAATATTTACCAGATCTTTTAAGCGGTAAAAAAATAGGTGCTTTTGGTTTAACAGAACCTAATGCTGGTACAGATG
CATCTGCTCAACAAAGTATAGCTGTTTTAGAAGGAGATCATTATATATTAAATGGATCAAAAATATTTATAACTAATGGT
GGAGCAGCAGATACATTTGTAATATTTGCTATGACAGATAGAAGTAAGGGCGTTAAAGGAATTTCCGCATTTATATTAGA
AAAAGGAATGCCCGGATTTAGCATTGGCAAGACAGAGGATAAAATGGGAATAAGAGCATCATCAACTACTGAACTTATAT
TTGAAGATGTAAAAGTTCCAAAAGAAAATTTACTTGGTAAAGAAGGAAAAGGATTTGGTATAGCTATGAAAACTTTAGAT
GGCGGAAGAATTGGAATAGCAGCTCAAGCATTAGGAATAGCAGAAGGCGCTTTAGATCACGCTATTGCATATATGAAAGA
AAGAAAACAATTCGGTAAAAATCTTACTAAATTTCAAGGATTGCAATGGTATATAGCAGATATGAAAGTGAGAGTAGATG
CTGCTAAATATCTTGTTTACAAATCAGCATGGAAAAAATCTGCAGGAAAAAATTACACAGTTGATGCAGCTGAGGCTAAA
CTGTATGCAGCTGAAACAGCTATGTATGTAACAAATAAATCTCTACAAGTATTGGGTGGATATGGATACACTAAAGATTA
TCCATTAGAAAGAATGTTAAGAGATGCTAGAATAACTGAAATATATGAAGGAACTTCAGAAGTACAAAAAATGGTTATAG
CTAATAACTTATTACACTAG

Upstream 100 bases:

>100_bases
TTAATGATGCAATTAAATATAATACAAATTTTTTATTATGATTTTAATATTAAAGCTTTATAGCTAAAATAAAGTTTCGG
AAATAATAGGGGGATTAAAT

Downstream 100 bases:

>100_bases
GAGGAGTTTATATGAATATAGTTGTTTGTTTAAAACAAGTACCAGATACAAATGAAGTTAAAATAGATCCTGTAAAAGGA
ACTCTAATAAGAGACGGAGT

Product: butyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYGGAGTDYLSYVIAVEELAKEC
ATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKIGAFGLTEPNAGTDASAQQSIAVLEGDHYILNGSKIFITNG
GAADTFVIFAMTDRSKGVKGISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKENLLGKEGKGFGIAMKTLD
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVYKSAWKKSAGKNYTVDAAEAK
LYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITEIYEGTSEVQKMVIANNLLH

Sequences:

>Translated_379_residues
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYGGAGTDYLSYVIAVEELAKEC
ATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKIGAFGLTEPNAGTDASAQQSIAVLEGDHYILNGSKIFITNG
GAADTFVIFAMTDRSKGVKGISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKENLLGKEGKGFGIAMKTLD
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVYKSAWKKSAGKNYTVDAAEAK
LYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITEIYEGTSEVQKMVIANNLLH
>Mature_379_residues
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYGGAGTDYLSYVIAVEELAKEC
ATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKIGAFGLTEPNAGTDASAQQSIAVLEGDHYILNGSKIFITNG
GAADTFVIFAMTDRSKGVKGISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKENLLGKEGKGFGIAMKTLD
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVYKSAWKKSAGKNYTVDAAEAK
LYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITEIYEGTSEVQKMVIANNLLH

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=49.0666666666667, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=42.627345844504, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI226958412, Length=374, Percent_Identity=41.7112299465241, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI226958414, Length=336, Percent_Identity=43.1547619047619, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=38.8888888888889, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=37.6, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=37.6, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=41.6438356164384, Blast_Score=265, Evalue=6e-71,
Organism=Homo sapiens, GI76496475, Length=374, Percent_Identity=36.8983957219251, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI4557235, Length=374, Percent_Identity=36.8983957219251, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=34.7480106100796, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=30.6666666666667, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=30.958904109589, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI48976061, Length=398, Percent_Identity=27.8894472361809, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI211971008, Length=398, Percent_Identity=27.8894472361809, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI38505218, Length=357, Percent_Identity=27.4509803921569, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786223, Length=379, Percent_Identity=29.287598944591, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=30.4461942257218, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=25.2595155709343, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081702, Length=264, Percent_Identity=24.6212121212121, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=40.8108108108108, Blast_Score=312, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17506239, Length=370, Percent_Identity=41.3513513513514, Blast_Score=310, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=39.3139841688654, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=39.5287958115183, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=37.7952755905512, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=38.5826771653543, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=37.6657824933687, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=42.1768707482993, Blast_Score=254, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=38.6422976501305, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=44.9781659388646, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=32.7956989247312, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=330, Percent_Identity=37.8787878787879, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71982178, Length=272, Percent_Identity=37.8676470588235, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=31.4207650273224, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=30.7065217391304, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17531909, Length=237, Percent_Identity=35.0210970464135, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=336, Percent_Identity=29.1666666666667, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=32.9545454545455, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI86563383, Length=265, Percent_Identity=27.9245283018868, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=265, Percent_Identity=27.9245283018868, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17540912, Length=338, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=47.3262032085562, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=44.1176470588235, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI24666513, Length=370, Percent_Identity=38.3783783783784, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=38.0952380952381, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=38.7434554973822, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI281363737, Length=385, Percent_Identity=37.4025974025974, Blast_Score=250, Evalue=9e-67,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=29.3650793650794, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24652780, Length=352, Percent_Identity=22.4431818181818, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41527; Mature: 41527

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYG
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHC
GAGTDYLSYVIAVEELAKECATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCCCCC
GAFGLTEPNAGTDASAQQSIAVLEGDHYILNGSKIFITNGGAADTFVIFAMTDRSKGVKG
CCCCCCCCCCCCCCCHHCCEEEEECCEEEEECCEEEEECCCCCCEEEEEEEECCCCCCHH
ISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKENLLGKEGKGFGIAMKTLD
HHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCEEEEEECC
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEEEEEHHHHHHHH
KSAWKKSAGKNYTVDAAEAKLYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITE
HHHHHHCCCCCEEEEHHHHHHHHHHEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIANNLLH
HHCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEFGLSQEQKLVKQMLMEFVENEVEPIAADIDKTERYPIETVEKMAKYGIMGMPFPKEYG
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHC
GAGTDYLSYVIAVEELAKECATTSVILSAHTSLCCAPIFEFGTEEQKKKYLPDLLSGKKI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCCCCC
GAFGLTEPNAGTDASAQQSIAVLEGDHYILNGSKIFITNGGAADTFVIFAMTDRSKGVKG
CCCCCCCCCCCCCCCHHCCEEEEECCEEEEECCEEEEECCCCCCEEEEEEEECCCCCCHH
ISAFILEKGMPGFSIGKTEDKMGIRASSTTELIFEDVKVPKENLLGKEGKGFGIAMKTLD
HHHHHHHCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCEEEEEECC
GGRIGIAAQALGIAEGALDHAIAYMKERKQFGKNLTKFQGLQWYIADMKVRVDAAKYLVY
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEEEEEEEEHHHHHHHH
KSAWKKSAGKNYTVDAAEAKLYAAETAMYVTNKSLQVLGGYGYTKDYPLERMLRDARITE
HHHHHHCCCCCEEEEHHHHHHHHHHEEEEEECCCEEEEECCCCCCCCCHHHHHHHHHHHH
IYEGTSEVQKMVIANNLLH
HHCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]