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The map label for this gene is etfA [H]

Identifier: 226950625

GI number: 226950625

Start: 3647649

End: 3648656

Strand: Reverse

Name: etfA [H]

Synonym: CLM_3609

Alternate gene names: 226950625

Gene position: 3648656-3647649 (Counterclockwise)

Preceding gene: 226950626

Following gene: 226950624

Centisome position: 87.81

GC content: 29.76

Gene sequence:

>1008_bases
ATGATGAATTTATCAGATTTTAAAGGTGTTTGGATTTTTGCAGAACAGAGAGAAGGTAAGCTTCAAAAAGTAGCTTTAGA
GCTAATAGGTAAAGGTAAAGAGTTATCTAAAAAATTAGGAGTAGAATTAACTGCTGTTTTATTAGGATATAATATTGATG
ATATACCAAGACAATTAATAGAGTATGGTGCAGATAAAGTATTATATGTGAATAATCCATTATTAAAAAATTATACTACA
GATGGATATACAAAAGTTATAAATGATTTAATAGAAGAAAGAAAACCTGAAATATTATTAGTTGGAGCTACTTATATAGG
AAGAGATTTAGCACCTAGAATTTCATCAAGATTAGGTACAGGACTTACAGCAGATTGTACAGGATTAGATATAGATGATG
ATACAAGAAATCTTTTAATGACAAGACCTGCTTTTGGTGGTAATTTAATGGCTACAATAATTTGTGACAGCAATAGACCT
CAAATGTCTACAGTAAGGCCAGGAGTTTTTGAAAAGTTAGAAAAAGATGCTAATAGAGATGGAAGTATTGAAAATATAAA
AGTAAATTTAAAAGAATCAGATATAAAAATAAAAATAAAAGAAATTGTTAAGCTAGCAAAAGAAATAGAAGATATAGGTG
AAGCAAAAATATTAGTTTCAGGTGGAAGAGGACTTGGAAGCCCAGAAGGATTTAAATTATTAAGAGAATTGGCTGATTTA
ATGGGAGGAGCTATATCAGGTTCTCGTGCGGTTGTAGATAGTGGATGGATAGATAAAGCTTATCAGGTTGGACAAACAGG
AAAAACAGTTAGACCTAATTTATATATAGCTTGTGGAATATCAGGAGCTATTCAGCATCTAGCAGGAATGCAAGACAGTG
ACTATATTATAGCTATAAATAAAGATGAATCAGCACCAATAATGCAAGTAGCAGATTTATCTATAGTAGGAGATTACAAA
AAAATATTACCTTCTATGATAGATGAAATAAAAAAGATTAATAATTAG

Upstream 100 bases:

>100_bases
AAAAAGAGAAGGAGTTTTGGTAAATAAGCCTTTTAAAGAAGCGGCACAGTATGCAGCAGAAAAATTAAAAGAAAAACATT
TTATTTAGGTTGGGGGAGAT

Downstream 100 bases:

>100_bases
ATAAAATAGTAATAGTTACTTCAAAATTTGATTATAAAATATATTGTAATCATATAAAAAAAGAATGTGAAATATAAATA
ATATATCACATTCTTTTTTT

Product: electron transfer flavoprotein subunit alpha/FixB family protein

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MMNLSDFKGVWIFAEQREGKLQKVALELIGKGKELSKKLGVELTAVLLGYNIDDIPRQLIEYGADKVLYVNNPLLKNYTT
DGYTKVINDLIEERKPEILLVGATYIGRDLAPRISSRLGTGLTADCTGLDIDDDTRNLLMTRPAFGGNLMATIICDSNRP
QMSTVRPGVFEKLEKDANRDGSIENIKVNLKESDIKIKIKEIVKLAKEIEDIGEAKILVSGGRGLGSPEGFKLLRELADL
MGGAISGSRAVVDSGWIDKAYQVGQTGKTVRPNLYIACGISGAIQHLAGMQDSDYIIAINKDESAPIMQVADLSIVGDYK
KILPSMIDEIKKINN

Sequences:

>Translated_335_residues
MMNLSDFKGVWIFAEQREGKLQKVALELIGKGKELSKKLGVELTAVLLGYNIDDIPRQLIEYGADKVLYVNNPLLKNYTT
DGYTKVINDLIEERKPEILLVGATYIGRDLAPRISSRLGTGLTADCTGLDIDDDTRNLLMTRPAFGGNLMATIICDSNRP
QMSTVRPGVFEKLEKDANRDGSIENIKVNLKESDIKIKIKEIVKLAKEIEDIGEAKILVSGGRGLGSPEGFKLLRELADL
MGGAISGSRAVVDSGWIDKAYQVGQTGKTVRPNLYIACGISGAIQHLAGMQDSDYIIAINKDESAPIMQVADLSIVGDYK
KILPSMIDEIKKINN
>Mature_335_residues
MMNLSDFKGVWIFAEQREGKLQKVALELIGKGKELSKKLGVELTAVLLGYNIDDIPRQLIEYGADKVLYVNNPLLKNYTT
DGYTKVINDLIEERKPEILLVGATYIGRDLAPRISSRLGTGLTADCTGLDIDDDTRNLLMTRPAFGGNLMATIICDSNRP
QMSTVRPGVFEKLEKDANRDGSIENIKVNLKESDIKIKIKEIVKLAKEIEDIGEAKILVSGGRGLGSPEGFKLLRELADL
MGGAISGSRAVVDSGWIDKAYQVGQTGKTVRPNLYIACGISGAIQHLAGMQDSDYIIAINKDESAPIMQVADLSIVGDYK
KILPSMIDEIKKINN

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=334, Percent_Identity=36.2275449101796, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI189181759, Length=273, Percent_Identity=39.5604395604396, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1787990, Length=334, Percent_Identity=29.6407185628743, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786226, Length=334, Percent_Identity=29.3413173652695, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082157, Length=253, Percent_Identity=25.6916996047431, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=331, Percent_Identity=36.2537764350453, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6325261, Length=235, Percent_Identity=35.7446808510638, Blast_Score=151, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17136898, Length=321, Percent_Identity=34.5794392523364, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24652801, Length=321, Percent_Identity=34.5794392523364, Blast_Score=167, Evalue=8e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 36657; Mature: 36657

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNLSDFKGVWIFAEQREGKLQKVALELIGKGKELSKKLGVELTAVLLGYNIDDIPRQLI
CCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHCCEEEEHHHCCCCCHHHHHHH
EYGADKVLYVNNPLLKNYTTDGYTKVINDLIEERKPEILLVGATYIGRDLAPRISSRLGT
HHCCCEEEEECCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHHHHHHCC
GLTADCTGLDIDDDTRNLLMTRPAFGGNLMATIICDSNRPQMSTVRPGVFEKLEKDANRD
CCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCC
GSIENIKVNLKESDIKIKIKEIVKLAKEIEDIGEAKILVSGGRGLGSPEGFKLLRELADL
CCEEEEEEEEECCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHH
MGGAISGSRAVVDSGWIDKAYQVGQTGKTVRPNLYIACGISGAIQHLAGMQDSDYIIAIN
HCCCCCCCCEEEECCCCHHHHHCCCCCCEECCCEEEEECCHHHHHHHHCCCCCCEEEEEC
KDESAPIMQVADLSIVGDYKKILPSMIDEIKKINN
CCCCCCEEEEECHHEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNLSDFKGVWIFAEQREGKLQKVALELIGKGKELSKKLGVELTAVLLGYNIDDIPRQLI
CCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHCCEEEEHHHCCCCCHHHHHHH
EYGADKVLYVNNPLLKNYTTDGYTKVINDLIEERKPEILLVGATYIGRDLAPRISSRLGT
HHCCCEEEEECCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEECHHHCCHHHHHHHHHHCC
GLTADCTGLDIDDDTRNLLMTRPAFGGNLMATIICDSNRPQMSTVRPGVFEKLEKDANRD
CCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCC
GSIENIKVNLKESDIKIKIKEIVKLAKEIEDIGEAKILVSGGRGLGSPEGFKLLRELADL
CCEEEEEEEEECCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHH
MGGAISGSRAVVDSGWIDKAYQVGQTGKTVRPNLYIACGISGAIQHLAGMQDSDYIIAIN
HCCCCCCCCEEEECCCCHHHHHCCCCCCEECCCEEEEECCHHHHHHHHCCCCCCEEEEEC
KDESAPIMQVADLSIVGDYKKILPSMIDEIKKINN
CCCCCCEEEEECHHEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]