Click here to switch to the map view.

The map label for this gene is argH [H]

Identifier: 226950081

GI number: 226950081

Start: 3032336

End: 3033658

Strand: Reverse

Name: argH [H]

Synonym: CLM_3034

Alternate gene names: 226950081

Gene position: 3033658-3032336 (Counterclockwise)

Preceding gene: 226950082

Following gene: 226950080

Centisome position: 73.01

GC content: 29.1

Gene sequence:

>1323_bases
ATGAAACTTTGGGGAGGACGTTTTAAGGAAGAAGAAAGCAAACTTATGGAGGACTTTAATAGTTCTCTAAGTTTTGATAA
AAAACTTTATTATGAAGATATAAAAGGAAGCATAGCTCATGTTAAAATGCTTACGAATCAAAATATAATAAAGGAAGAAG
AAAAAGAAAAAATATTGCTTGGGTTAGAGGAAATATTAAAAGAAATAGATGAAGGGATTTTAAAAATAGAGGGAGACTAT
GAGGATATTCATAGCTTTGTGGAAATAAATTTAATAAACAAAATAGGAAATGTGGGAAAAAAGCTTCATACGGGAAGAAG
TAGAAATGACCAAGTAGCCTTAGATATGAAATTATATGCTAAAAAATCCACGGAAGAAGTAATAGAATGCTTAAAGGAAC
TTATGGATTCTTTAATTAAAGTTGGAAATGAAAATAATTATATTATGCCAGGATATACTCATCTTCAAAGAGCTCAAGTG
GTAACTTTTAGGTATCATTTGTTAGCTTATTTTGAAATGTTTAAAAGAGATGAGAAAAGATTAGAAAATGCCTTAGAGAT
TTTAAATGAAAGTCCTTTAGGATCAGGAGCCTTAGCGGGAAGTACTTATAACATAGATAGAGAATATACTGCTAAGTTAT
TGGGTTTTAGAAAACCGGTAGATAATTTTTTAGATGGAGTTAGTGATAGGGATTATATAATAGAACTTATAAGTAAGTTT
TCTATAATAATGATGCATTTAAGTAGATTATCTGAAGAACTTATACTTTGGAGTAGTAGTGAATTTAGGTTTATACAAAT
AGGAGATGCTTATTCCACAGGCAGTAGTATAATGCCTCAAAAGAAAAACCCAGATGGGGCGGAACTTATACGCGGGAAAA
TTGGAAGGGTATATGGGGACTTAATAAGTATATTAACAGTTATGAAATCATTACCATTAGCTTATAATAAAGATATGCAG
GAGGATAAAGAACCTTTCTTTGATGCAAAAGATACTGTAATAAGCTGTTTAAAAGTAATGGAAGGTATAATATCTACTCT
AAAAGTAAATAAAGAAAATTTAATGAAATCTGTGAAGAAAGGATTTTTAAATGCCACAGAAGCAGCAGATTATTTAGTAA
ATAAAGGAATGGCTTTTAGAGATGCACATAAAGTTATAGGTGAAGTTGTAATATACTGTGAGGATAAAAATTCAGCTATA
GAGGATTTATCCTTAGAAGAATTAAAACAATTTTCAGATCTATTTTGTGAGGATATTTATGAATTTATAGATTATAAGAA
TTCTATAAACAAAGGGATAAAAAAAGAAATGGGATACTTTTAA

Upstream 100 bases:

>100_bases
TTACAGTCATAAAGATGCAGAAGGCTTTATAAATTTATTTGGATTACCATCCAAAATAAAAGCGTTAAAAAATTTCTAGA
CTAAATTGGAGGAACATACT

Downstream 100 bases:

>100_bases
GAGGATTATAATTTATAGTCTTTAAAGGTTGAAAACTAAAGCAGAAATACTTTTAGTCAATAGATAGCCATGAAATAAAG
AATACTAATAATATTAGTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIKGSIAHVKMLTNQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDY
EDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQV
VTFRYHLLAYFEMFKRDEKRLENALEILNESPLGSGALAGSTYNIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKIGRVYGDLISILTVMKSLPLAYNKDMQ
EDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEVVIYCEDKNSAI
EDLSLEELKQFSDLFCEDIYEFIDYKNSINKGIKKEMGYF

Sequences:

>Translated_440_residues
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIKGSIAHVKMLTNQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDY
EDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQV
VTFRYHLLAYFEMFKRDEKRLENALEILNESPLGSGALAGSTYNIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKIGRVYGDLISILTVMKSLPLAYNKDMQ
EDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEVVIYCEDKNSAI
EDLSLEELKQFSDLFCEDIYEFIDYKNSINKGIKKEMGYF
>Mature_440_residues
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIKGSIAHVKMLTNQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDY
EDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQV
VTFRYHLLAYFEMFKRDEKRLENALEILNESPLGSGALAGSTYNIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKIGRVYGDLISILTVMKSLPLAYNKDMQ
EDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEVVIYCEDKNSAI
EDLSLEELKQFSDLFCEDIYEFIDYKNSINKGIKKEMGYF

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=431, Percent_Identity=42.4593967517401, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=431, Percent_Identity=42.4593967517401, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=431, Percent_Identity=40.6032482598608, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI68303547, Length=431, Percent_Identity=40.3712296983759, Blast_Score=337, Evalue=1e-92,
Organism=Escherichia coli, GI1790398, Length=437, Percent_Identity=47.3684210526316, Blast_Score=431, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321806, Length=434, Percent_Identity=45.3917050691244, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221473854, Length=431, Percent_Identity=40.6032482598608, Blast_Score=341, Evalue=7e-94,
Organism=Drosophila melanogaster, GI78706858, Length=431, Percent_Identity=40.6032482598608, Blast_Score=341, Evalue=7e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50511; Mature: 50511

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIKGSIAHVKMLTNQNIIKEEEKEKILL
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
GLEEILKEIDEGILKIEGDYEDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYA
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHH
KKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQVVTFRYHLLAYFEMFKRDEKR
CCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENALEILNESPLGSGALAGSTYNIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHH
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKIGRVYGD
HHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LISILTVMKSLPLAYNKDMQEDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKK
HHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GFLNATEAADYLVNKGMAFRDAHKVIGEVVIYCEDKNSAIEDLSLEELKQFSDLFCEDIY
HCCCHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHH
EFIDYKNSINKGIKKEMGYF
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIKGSIAHVKMLTNQNIIKEEEKEKILL
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
GLEEILKEIDEGILKIEGDYEDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYA
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHH
KKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQVVTFRYHLLAYFEMFKRDEKR
CCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENALEILNESPLGSGALAGSTYNIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHH
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKIGRVYGD
HHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LISILTVMKSLPLAYNKDMQEDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKK
HHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GFLNATEAADYLVNKGMAFRDAHKVIGEVVIYCEDKNSAIEDLSLEELKQFSDLFCEDIY
HCCCHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHH
EFIDYKNSINKGIKKEMGYF
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA