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The map label for this gene is typA [H]

Identifier: 226949913

GI number: 226949913

Start: 2868545

End: 2870371

Strand: Reverse

Name: typA [H]

Synonym: CLM_2865

Alternate gene names: 226949913

Gene position: 2870371-2868545 (Counterclockwise)

Preceding gene: 226949914

Following gene: 226949912

Centisome position: 69.08

GC content: 31.8

Gene sequence:

>1827_bases
ATGAGTTTATTTGTTAGAAATGACATTAGAAATGTGGCCATAATTGCTCACGTTGACCACGGTAAGACAACACTTGTAGA
TGCACTTTTAAGACAGAGCCACGTTTTTAGAGACAACGAAAAAGTAGAGGAAAGAGTTATGGACTCTAATGACATAGAAA
AAGAAAGAGGAATAACTATATTATCTAAAAATACTGCGGTAAATTATAATGGTATTAAAATAAATATAGTAGATACTCCA
GGACATGCAGATTTTGGAGGAGAAGTTGAACGTGTACTAAAAATGGTAGATAGCGTTTTATTAGTAGTAGACTCCTATGA
GGGGGCTATGCCGCAAACAAAATTTGTTACTAAAAAGGCATTAGAACTTAATCTTAAGCCAATAGTAGTAATAAATAAAA
TTGATAAACCAGATGGTAGACCAGAAGAAGTATTAGACGAAATATTTGACTTATTTGTAGAACTTGGAGCTAATGATGAT
CAATTAGATTTCCCAGTAATATATTGTTCAGCTAGGGACGGTATAGCTAAAAATGAAATGGAAGACGAATCAGATAATAT
GGAAGCTTTATTTGAAGCTATAATTAAAAATGTTAAGTCACCAGAAGGACATATAGATAAGCCATTGCAAATGCTAGTAA
CTACTATAGATTACAACGAATATGTAGGTAAAATAGGTATTGGTAAAATAGAAAGAGGAAGTATAAAGAAAAACCAACAA
GTGGCTTTAATAAGAAAAGATGGAAAAGTGGAAAATGTAAAAATATCTTCATTATATGTTTATGATGGATTAGCAAGAAT
AGAAACAGAAGAAGCTAAATTAGGGGATATAGTGGCGGTAGCAGGTATACCAGATATTAATATAGGAGAAACTGTAGCAG
ATGTTAATGAACCAGAGGCCCTTCCTTTTGTAGAAATAGATGAACCTACATTAAGTATGAACTTTATGGTTAATGATTCT
CCTTTTGCAGGACAAGATGGTAAGTTTGTCACATCAAGACATTTAAGAGACAGACTTATAAAAGAGTTAGAAACTAATGT
AAGCTTAAGGGTAGAAGATACAGATAGAGCAGAATGTTTCAAAGTAAGTGGAAGAGGAGAACTTCATTTATCTGTATTAA
TAGAAACTATGAGAAGAGAAGGTTACGAATTCCAAGTTTCAAAACCAACAGTTATATTCAAAGAAGAGAATGGTAAAAAA
TTAGAGCCTATTGAAAGATTAACTATAGATGTACCAGAAGAATTTATGGGCGTAGTTATGGAAAAATTAGGACCAAGAAA
AGCTGAGATGGTTAATATGACTTCAGCTATAAATGGTTATACAAGATTAGAATTTAAAGTTCCAGCAAGAGGATTAATAG
GATTTAGAAATGAATTTATGACTGATACTAAGGGTAACGGTATAATGAATCATGTATTAGAAGATTATGAACCATATAAA
GGAGAAATACCTGAAAGATCAAGAGGATCATTAGTAGTATTTGAATCTGGGGAAGCTATAACTTATGGATTATTTAATGC
TCAAGAAAGAGGAATACTATTTTTAGAACCAGGGACTCCAGTATATGCAGGTATGATAGCAGGACAATGTTCTAGAACAG
GGGATATAGATGTTAATGTATGTAAGAAAAAACATTTATCTAATACTAGATCTTCAGGTGCAGATGAAGCTTTAAAGTTA
GTTCCAGTGACAAAAATGTCCCTAGAACAATGTCTTGAATTTGTAGCATCTGATGAATTAGTAGAAGTTACTCCAAAAAA
TATAAGGATGAGAAAGAAAATATTGGATTCAGAATTAAGAAGAAAAGCTACAATAAGAAAAAAATAA

Upstream 100 bases:

>100_bases
CCGGGACTTAGTGCCATTTATTTAATAATCATAGATTAATGGTACTTATCTGTGAGATAAAATATATAAGTTTTTTAATT
TAATAATTGGAGGAAAGAAT

Downstream 100 bases:

>100_bases
ATAGTCATTATAATTCTAAACGAACAACTAGCTTAGAGCTGGTTGTTTGTCTATATTAACCTATGGGTGGTGATTTTATG
AAAAATAAAAACAGGCTAAT

Product: GTP-binding protein TypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSLFVRNDIRNVAIIAHVDHGKTTLVDALLRQSHVFRDNEKVEERVMDSNDIEKERGITILSKNTAVNYNGIKINIVDTP
GHADFGGEVERVLKMVDSVLLVVDSYEGAMPQTKFVTKKALELNLKPIVVINKIDKPDGRPEEVLDEIFDLFVELGANDD
QLDFPVIYCSARDGIAKNEMEDESDNMEALFEAIIKNVKSPEGHIDKPLQMLVTTIDYNEYVGKIGIGKIERGSIKKNQQ
VALIRKDGKVENVKISSLYVYDGLARIETEEAKLGDIVAVAGIPDINIGETVADVNEPEALPFVEIDEPTLSMNFMVNDS
PFAGQDGKFVTSRHLRDRLIKELETNVSLRVEDTDRAECFKVSGRGELHLSVLIETMRREGYEFQVSKPTVIFKEENGKK
LEPIERLTIDVPEEFMGVVMEKLGPRKAEMVNMTSAINGYTRLEFKVPARGLIGFRNEFMTDTKGNGIMNHVLEDYEPYK
GEIPERSRGSLVVFESGEAITYGLFNAQERGILFLEPGTPVYAGMIAGQCSRTGDIDVNVCKKKHLSNTRSSGADEALKL
VPVTKMSLEQCLEFVASDELVEVTPKNIRMRKKILDSELRRKATIRKK

Sequences:

>Translated_608_residues
MSLFVRNDIRNVAIIAHVDHGKTTLVDALLRQSHVFRDNEKVEERVMDSNDIEKERGITILSKNTAVNYNGIKINIVDTP
GHADFGGEVERVLKMVDSVLLVVDSYEGAMPQTKFVTKKALELNLKPIVVINKIDKPDGRPEEVLDEIFDLFVELGANDD
QLDFPVIYCSARDGIAKNEMEDESDNMEALFEAIIKNVKSPEGHIDKPLQMLVTTIDYNEYVGKIGIGKIERGSIKKNQQ
VALIRKDGKVENVKISSLYVYDGLARIETEEAKLGDIVAVAGIPDINIGETVADVNEPEALPFVEIDEPTLSMNFMVNDS
PFAGQDGKFVTSRHLRDRLIKELETNVSLRVEDTDRAECFKVSGRGELHLSVLIETMRREGYEFQVSKPTVIFKEENGKK
LEPIERLTIDVPEEFMGVVMEKLGPRKAEMVNMTSAINGYTRLEFKVPARGLIGFRNEFMTDTKGNGIMNHVLEDYEPYK
GEIPERSRGSLVVFESGEAITYGLFNAQERGILFLEPGTPVYAGMIAGQCSRTGDIDVNVCKKKHLSNTRSSGADEALKL
VPVTKMSLEQCLEFVASDELVEVTPKNIRMRKKILDSELRRKATIRKK
>Mature_607_residues
SLFVRNDIRNVAIIAHVDHGKTTLVDALLRQSHVFRDNEKVEERVMDSNDIEKERGITILSKNTAVNYNGIKINIVDTPG
HADFGGEVERVLKMVDSVLLVVDSYEGAMPQTKFVTKKALELNLKPIVVINKIDKPDGRPEEVLDEIFDLFVELGANDDQ
LDFPVIYCSARDGIAKNEMEDESDNMEALFEAIIKNVKSPEGHIDKPLQMLVTTIDYNEYVGKIGIGKIERGSIKKNQQV
ALIRKDGKVENVKISSLYVYDGLARIETEEAKLGDIVAVAGIPDINIGETVADVNEPEALPFVEIDEPTLSMNFMVNDSP
FAGQDGKFVTSRHLRDRLIKELETNVSLRVEDTDRAECFKVSGRGELHLSVLIETMRREGYEFQVSKPTVIFKEENGKKL
EPIERLTIDVPEEFMGVVMEKLGPRKAEMVNMTSAINGYTRLEFKVPARGLIGFRNEFMTDTKGNGIMNHVLEDYEPYKG
EIPERSRGSLVVFESGEAITYGLFNAQERGILFLEPGTPVYAGMIAGQCSRTGDIDVNVCKKKHLSNTRSSGADEALKLV
PVTKMSLEQCLEFVASDELVEVTPKNIRMRKKILDSELRRKATIRKK

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=494, Percent_Identity=28.7449392712551, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=41.3533834586466, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=36.0544217687075, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI18390331, Length=145, Percent_Identity=37.9310344827586, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI19923640, Length=130, Percent_Identity=39.2307692307692, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI25306287, Length=130, Percent_Identity=39.2307692307692, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI25306283, Length=130, Percent_Identity=39.2307692307692, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=37.8378378378378, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=37.8378378378378, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=37.8378378378378, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=38.9705882352941, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=38.9705882352941, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI34147630, Length=276, Percent_Identity=27.8985507246377, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI53729339, Length=230, Percent_Identity=31.304347826087, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI53729337, Length=230, Percent_Identity=31.304347826087, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI94966752, Length=129, Percent_Identity=31.0077519379845, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI48994988, Length=596, Percent_Identity=56.2080536912752, Blast_Score=684, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=504, Percent_Identity=26.7857142857143, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789738, Length=169, Percent_Identity=34.9112426035503, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=31.7241379310345, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789737, Length=240, Percent_Identity=30, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790412, Length=240, Percent_Identity=30, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789559, Length=173, Percent_Identity=30.635838150289, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=241, Percent_Identity=33.6099585062241, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17556745, Length=142, Percent_Identity=38.7323943661972, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17533571, Length=173, Percent_Identity=36.9942196531792, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17506493, Length=177, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=40.625, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=40.625, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=36.5671641791045, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556456, Length=277, Percent_Identity=27.7978339350181, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71994658, Length=369, Percent_Identity=24.390243902439, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25141371, Length=257, Percent_Identity=29.9610894941634, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=487, Percent_Identity=30.1848049281314, Blast_Score=161, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324707, Length=148, Percent_Identity=39.8648648648649, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=148, Percent_Identity=39.8648648648649, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=152, Percent_Identity=35.5263157894737, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=274, Percent_Identity=28.1021897810219, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322359, Length=149, Percent_Identity=34.8993288590604, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=149, Percent_Identity=34.8993288590604, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324550, Length=189, Percent_Identity=31.7460317460317, Blast_Score=68, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322937, Length=370, Percent_Identity=24.8648648648649, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI78706572, Length=420, Percent_Identity=25.4761904761905, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=35.0993377483444, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=35.0993377483444, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=35.0993377483444, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24582462, Length=146, Percent_Identity=39.041095890411, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574573, Length=198, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363316, Length=324, Percent_Identity=29.320987654321, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17864358, Length=324, Percent_Identity=29.320987654321, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21357743, Length=171, Percent_Identity=35.672514619883, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921738, Length=251, Percent_Identity=30.2788844621514, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221458488, Length=160, Percent_Identity=37.5, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28572034, Length=234, Percent_Identity=30.3418803418803, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 68160; Mature: 68029

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFVRNDIRNVAIIAHVDHGKTTLVDALLRQSHVFRDNEKVEERVMDSNDIEKERGITI
CCEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHCCEEE
LSKNTAVNYNGIKINIVDTPGHADFGGEVERVLKMVDSVLLVVDSYEGAMPQTKFVTKKA
EECCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHH
LELNLKPIVVINKIDKPDGRPEEVLDEIFDLFVELGANDDQLDFPVIYCSARDGIAKNEM
HEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCC
EDESDNMEALFEAIIKNVKSPEGHIDKPLQMLVTTIDYNEYVGKIGIGKIERGSIKKNQQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCE
VALIRKDGKVENVKISSLYVYDGLARIETEEAKLGDIVAVAGIPDINIGETVADVNEPEA
EEEEECCCCEEEEEEEEEEEECCHHHEECCCCCCCCEEEEECCCCCCCCCHHHCCCCCCC
LPFVEIDEPTLSMNFMVNDSPFAGQDGKFVTSRHLRDRLIKELETNVSLRVEDTDRAECF
CCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEE
KVSGRGELHLSVLIETMRREGYEFQVSKPTVIFKEENGKKLEPIERLTIDVPEEFMGVVM
EECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCHHHEEECCCHHHHHHHH
EKLGPRKAEMVNMTSAINGYTRLEFKVPARGLIGFRNEFMTDTKGNGIMNHVLEDYEPYK
HHHCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
GEIPERSRGSLVVFESGEAITYGLFNAQERGILFLEPGTPVYAGMIAGQCSRTGDIDVNV
CCCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEECCCCCEEHHHHHCCCCCCCCCCHHH
CKKKHLSNTRSSGADEALKLVPVTKMSLEQCLEFVASDELVEVTPKNIRMRKKILDSELR
HHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHH
RKATIRKK
HHHCCCCC
>Mature Secondary Structure 
SLFVRNDIRNVAIIAHVDHGKTTLVDALLRQSHVFRDNEKVEERVMDSNDIEKERGITI
CEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHCCEEE
LSKNTAVNYNGIKINIVDTPGHADFGGEVERVLKMVDSVLLVVDSYEGAMPQTKFVTKKA
EECCCEEEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHH
LELNLKPIVVINKIDKPDGRPEEVLDEIFDLFVELGANDDQLDFPVIYCSARDGIAKNEM
HEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCC
EDESDNMEALFEAIIKNVKSPEGHIDKPLQMLVTTIDYNEYVGKIGIGKIERGSIKKNQQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCE
VALIRKDGKVENVKISSLYVYDGLARIETEEAKLGDIVAVAGIPDINIGETVADVNEPEA
EEEEECCCCEEEEEEEEEEEECCHHHEECCCCCCCCEEEEECCCCCCCCCHHHCCCCCCC
LPFVEIDEPTLSMNFMVNDSPFAGQDGKFVTSRHLRDRLIKELETNVSLRVEDTDRAECF
CCEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEE
KVSGRGELHLSVLIETMRREGYEFQVSKPTVIFKEENGKKLEPIERLTIDVPEEFMGVVM
EECCCCCEEHHHHHHHHHHCCCEEEECCCEEEEECCCCCCCCCHHHEEECCCHHHHHHHH
EKLGPRKAEMVNMTSAINGYTRLEFKVPARGLIGFRNEFMTDTKGNGIMNHVLEDYEPYK
HHHCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCC
GEIPERSRGSLVVFESGEAITYGLFNAQERGILFLEPGTPVYAGMIAGQCSRTGDIDVNV
CCCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEECCCCCEEHHHHHCCCCCCCCCCHHH
CKKKHLSNTRSSGADEALKLVPVTKMSLEQCLEFVASDELVEVTPKNIRMRKKILDSELR
HHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHH
RKATIRKK
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]