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The map label for this gene is coaBC [H]

Identifier: 226949865

GI number: 226949865

Start: 2823514

End: 2824701

Strand: Reverse

Name: coaBC [H]

Synonym: CLM_2812

Alternate gene names: 226949865

Gene position: 2824701-2823514 (Counterclockwise)

Preceding gene: 226949866

Following gene: 226949864

Centisome position: 67.98

GC content: 30.05

Gene sequence:

>1188_bases
ATGAATAAAAAATGTGTAGTATTAGGTGTAACAGGAGGAATAGCTAGCTATAAAGCTCTAGATATAGTGAGCAAACTAAA
AAAGCTTAATTATGATGTAAATGTAATAATGACAAAGTCTGCACTACAGTTTATACATCCACTACCTTTTCAAAGTTTAA
GTGGTAATATGGTTTCAAAGGATATGTTTGAAGAACCAAAAGCCTTTGAAATACAACATATATCCTTAGCTAGAAAGGCA
GATATGATATTGGTAGCTCCTGCTACAGCTAATATTATTGGAAAAGTAGCTAATGGTATAGCTGATGATATGTTATCTAC
TACTATAATGGCAGCTACTTGTCCTGTAGTATTTGTACCAGCTATGAATACAAACATGTATAAAAATCCTATAGTAAAAA
ATAATATAGAAAAACTAAAAGGCTTTGGTTATGAATTTATTAACCCTATATCTGGAAGACTAGCCTGTGGAGATGTAGGG
GAAGGTAAAATGGCTGATACTGAAGACATAGTAGAAATAGCAGATAGTATGCTTTATCCTATAAAAGACTTAATAGGGAA
AAATATACTAGTTACTGCAGGGCCTACCCTAGCACCTATAGATCCAGTAAGATACATAACAAATAAATCTTCTGGAAAAA
TGGGATATTCTATAGCAAAGGAAGCTAGAGATAGAGGTGCAAAGGTTACATTAGTATCTGGCCCTACAAACTTAAAAACA
CCTTTAGGGTTGGATATAATAAAAGTTAATACAAATGAAGAGATGCTTAAAGCTGTTAAAGATAATTTTGAAAGGCAGCA
TATAGTTATAAAATCTGCAGCTGTGGCAGATTACAAACCTAAAGAATATAAAGAGCATAAAATAAAAAAAACCGGTGATG
ATTTCAATTTAGAGCTAATAAAAGATAAAGATATTTTAAAAGAATTAGGACTAATAAAAAAGAATCAAATATTGGTAGGC
TTTGCAGCAGAAAGTAAAGATCTTTTAGATAATGCTAAATCTAAATTAGAGAAAAAAAACTTAGATTTTATAGTAGCAAA
TAATATCCTGTCAAAGGAAACAGGATTTGCATCAGAGGATAATTTGGTTACAATAATATCTAAAGATGGATGTATTAAAA
ATTTAGAAAAGATGTCTAAAAGAGAAGTGGCTAAAGAGATATTTGATACTATATTAAATAAAAAATAA

Upstream 100 bases:

>100_bases
CTTGTAGATATAGATTCAACTAAACCTGTTACAGTAGCAATAAATGAAATACATGAAGGAAAAATAACCTATAAAACAGT
TAAAGAAGGAATAAAATAAA

Downstream 100 bases:

>100_bases
TATGAAAATAAAAGAGAGGCAATAACCTTATAAGTTAAGCCTCTTTTATTTAGCGGATAAACAGGTGCCTAGGCAATAAT
ATAGAGTTTTAGCCCTATGT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSKDMFEEPKAFEIQHISLARKA
DMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVPAMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVG
EGKMADTEDIVEIADSMLYPIKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDDFNLELIKDKDILKELGLIKKNQILVG
FAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASEDNLVTIISKDGCIKNLEKMSKREVAKEIFDTILNKK

Sequences:

>Translated_395_residues
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSKDMFEEPKAFEIQHISLARKA
DMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVPAMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVG
EGKMADTEDIVEIADSMLYPIKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDDFNLELIKDKDILKELGLIKKNQILVG
FAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASEDNLVTIISKDGCIKNLEKMSKREVAKEIFDTILNKK
>Mature_395_residues
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSKDMFEEPKAFEIQHISLARKA
DMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVPAMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVG
EGKMADTEDIVEIADSMLYPIKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDDFNLELIKDKDILKELGLIKKNQILVG
FAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASEDNLVTIISKDGCIKNLEKMSKREVAKEIFDTILNKK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=180, Percent_Identity=38.3333333333333, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI87082301, Length=371, Percent_Identity=42.8571428571429, Blast_Score=290, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17560194, Length=186, Percent_Identity=34.4086021505376, Blast_Score=98, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322762, Length=199, Percent_Identity=31.6582914572864, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=32.8042328042328, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43412; Mature: 43412

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSK
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCH
DMFEEPKAFEIQHISLARKADMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVP
HHHCCCCCEEEEEHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVGEGKMADTEDIVEIADSMLYP
CCCCCCCCCCCHHCCHHHHHCCCHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
IKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
HHHHHCCCEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDDFNLELI
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECHHCCCCCHHHHHHHHHCCCCCCEEEEE
KDKDILKELGLIKKNQILVGFAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASED
CCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCC
NLVTIISKDGCIKNLEKMSKREVAKEIFDTILNKK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKKCVVLGVTGGIASYKALDIVSKLKKLNYDVNVIMTKSALQFIHPLPFQSLSGNMVSK
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCCCCCCCCCCCH
DMFEEPKAFEIQHISLARKADMILVAPATANIIGKVANGIADDMLSTTIMAATCPVVFVP
HHHCCCCCEEEEEHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
AMNTNMYKNPIVKNNIEKLKGFGYEFINPISGRLACGDVGEGKMADTEDIVEIADSMLYP
CCCCCCCCCCCHHCCHHHHHCCCHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHH
IKDLIGKNILVTAGPTLAPIDPVRYITNKSSGKMGYSIAKEARDRGAKVTLVSGPTNLKT
HHHHHCCCEEEECCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCCCC
PLGLDIIKVNTNEEMLKAVKDNFERQHIVIKSAAVADYKPKEYKEHKIKKTGDDFNLELI
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEECHHCCCCCHHHHHHHHHCCCCCCEEEEE
KDKDILKELGLIKKNQILVGFAAESKDLLDNAKSKLEKKNLDFIVANNILSKETGFASED
CCHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCHHHCCCCCCCCC
NLVTIISKDGCIKNLEKMSKREVAKEIFDTILNKK
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]