| Definition | Clostridium botulinum A2 str. Kyoto chromosome, complete genome. |
|---|---|
| Accession | NC_012563 |
| Length | 4,155,278 |
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The map label for this gene is dxr [H]
Identifier: 226949779
GI number: 226949779
Start: 2734700
End: 2735857
Strand: Reverse
Name: dxr [H]
Synonym: CLM_2719
Alternate gene names: 226949779
Gene position: 2735857-2734700 (Counterclockwise)
Preceding gene: 226949780
Following gene: 226949778
Centisome position: 65.84
GC content: 30.31
Gene sequence:
>1158_bases TTGAAGAACATTACCATATTAGGCGCAACAGGTTCTATTGGAACCCAAACTTTAGATGTAATAAGAAGAGAAAAGGAAGA ATTAAAATTAGTAGCCATATCCGCGAATAAAAGCTATAAAAAAGTTATAGAAATTATAAAGGAATTTAAACCTAAATATG CGGTTTTAATGGAAGAGAATGCTTTTAAAATAGTAGAAGATTTTTGTATAGATAATAAAATAGATACAAAAGTTTTAAAA GGTATGGAAGGAATGATATATATAAGCACCTTAGAGGAGGTAAATACAGTAGTTACCTCTGTGGTAGGAATGATAGGATT AGTTCCAACCATAAAAGCTATAGAAAGTGGAAAAGATATAGCTTTAGCTAACAAAGAAACCTTAGTAGTAGCTGGAGAAC TAGTTATTAGTAAAGCTAAAGAGCATAATGTAAATATATTACCTGTAGATTCAGAACACGGAGCTATTTTTCAATGTTTA AGAGGAAATAAAAAGGAAGAAGTTAAAAATATAATAGTAACAGCTTCAGGAGGACCTTTTAGAGGTAAAAAGAAGGAAGA ACTCATAGATGTAAAGCCAGAGCATGCTCTTAAACATCCTAAATGGAATATGGGAAGAAAAATATCTATAGATTCTGCCA CATTAATGAATAAAGGGTTAGAGGTTATAGAAGCTCACTTTTTATTTGGTGTGGATTATGAAAATATAAAGGTGGTGGTA CATCCACAAAGTATAGTCCATTCTATGGTAGAATATAAAGATGGAAGTGTAATAGCACAAATGGCAACTCCAGATATGAA ATTACCTATACAATATGCTTTGAATTATCCTAATAGGAAAGAAAGTCAAATAGAACCTTTAGATTTTTATAAAATATCTA ATTTAACCTTTGAAAAACCGGATATGGATACATTCTTACCACTAAAGTTGGCTTATGAAGCAGGGAAAAAAGGTGGAGTA ATGCCAGCCATATTAAATGGGGCCAATGAGGTTGCAGTAGATTTATTTTTAAAGGGCAAAATAGAATTTTTACAAATAGG TGACCTATTACAAGAATGTATGAATAAATTTTATAAATCTATGGAAGCTACATTAGAGAATGTAATAAGTGTAGATAAGG AAGTTAGAGAGTATTTAGGTAAAAAATATGATATATAA
Upstream 100 bases:
>100_bases TTTTTTAGGGTTACTTCTAGGACCATTATATATAATAACCCTTAAAGAATTTGTAAAAACTTAAATGAAAGTTAAAAGTT ATTAGAGGAGAGATGACATT
Downstream 100 bases:
>100_bases TAATAAAATTAATTTATAGGCACAATTTTAAGGGAGGTTAGTTAATGTATATAGTAGCGGCTATTTTAGCCTTTGGCATA TTAGTTTTAGTCCATGAATT
Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Products: NA
Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]
Number of amino acids: Translated: 385; Mature: 385
Protein sequence:
>385_residues MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL RGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGV MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI
Sequences:
>Translated_385_residues MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL RGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGV MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI >Mature_385_residues MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEENAFKIVEDFCIDNKIDTKVLK GMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDIALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCL RGNKKEEVKNIIVTASGGPFRGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKPDMDTFLPLKLAYEAGKKGGV MPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKSMEATLENVISVDKEVREYLGKKYDI
Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]
COG id: COG0743
COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DXR family [H]
Homologues:
Organism=Escherichia coli, GI1786369, Length=392, Percent_Identity=43.8775510204082, Blast_Score=337, Evalue=1e-93,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003821 - InterPro: IPR013644 - InterPro: IPR013512 - InterPro: IPR016040 [H]
Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]
EC number: =1.1.1.267 [H]
Molecular weight: Translated: 43039; Mature: 43039
Theoretical pI: Translated: 6.89; Mature: 6.89
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.6 %Met (Translated Protein) 4.4 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEEN CCCEEEEECCCCCCHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC AFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDI HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE ALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPF EEECCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEEEEEECCCCC RGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV CCCCHHHHCCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHEEHHHEECCCCCEEEEE HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKP CCHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEECCCCCCCCCCCCCCEEEECCCEECCC DMDTFLPLKLAYEAGKKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKS CCCCCCHHHHEECCCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH MEATLENVISVDKEVREYLGKKYDI HHHHHHHHHHHHHHHHHHCCCCCCC >Mature Secondary Structure MKNITILGATGSIGTQTLDVIRREKEELKLVAISANKSYKKVIEIIKEFKPKYAVLMEEN CCCEEEEECCCCCCHHHHHHHHHCHHHEEEEEEECCCCHHHHHHHHHHCCCCEEEEEECC AFKIVEDFCIDNKIDTKVLKGMEGMIYISTLEEVNTVVTSVVGMIGLVPTIKAIESGKDI HHHHHHHHHCCCCCHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE ALANKETLVVAGELVISKAKEHNVNILPVDSEHGAIFQCLRGNKKEEVKNIIVTASGGPF EEECCCEEEEEHHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHCEEEEEECCCCC RGKKKEELIDVKPEHALKHPKWNMGRKISIDSATLMNKGLEVIEAHFLFGVDYENIKVVV CCCCHHHHCCCCCHHHHCCCCCCCCCEEECCHHHHHHHCHHHHEEHHHEECCCCCEEEEE HPQSIVHSMVEYKDGSVIAQMATPDMKLPIQYALNYPNRKESQIEPLDFYKISNLTFEKP CCHHHHHHHHHCCCCCEEEEECCCCCCCCHHEEECCCCCCCCCCCCCCEEEECCCEECCC DMDTFLPLKLAYEAGKKGGVMPAILNGANEVAVDLFLKGKIEFLQIGDLLQECMNKFYKS CCCCCCHHHHEECCCCCCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHH MEATLENVISVDKEVREYLGKKYDI HHHHHHHHHHHHHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA