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The map label for this gene is ymxG [H]

Identifier: 226949764

GI number: 226949764

Start: 2715612

End: 2716913

Strand: Reverse

Name: ymxG [H]

Synonym: CLM_2704

Alternate gene names: 226949764

Gene position: 2716913-2715612 (Counterclockwise)

Preceding gene: 226949765

Following gene: 226949763

Centisome position: 65.38

GC content: 26.5

Gene sequence:

>1302_bases
GTGTATAATTTATTTACATTAGATAATGGACTAAGAGTGGTTCTAGAGAATATAGATTATGTGAAATCTGTAAGTGTAGG
ACTTTGGATAGAAAATGGTTCAAGAAATGAGAATTTAAAAAATAATGGTATTTCTCATTTTATAGAGCATATGATGTTTA
AAGGCACAGAAAATAGAAGTGCACTACAAATAGCAGAATGTATAGAAGATGTAGGTGGACAAATAAATGCATTTACAGGT
AAAGAAGCCACTTGTTATTATATAAAAATACTAAATTCTCATATAGAATTAGCTTTAGAAGTTTTATCTGATATGTTATT
TAATAGTAAATTTAAAGAAGAGGACATAGAAAAAGAAAAGGGAGTAATAATTGAAGAAATAAGTATGACTGAAGATTCTC
CGGAGGATGTACTATCAGATTTACATTGCAAGGCTATATGGGGAGATGATTCTATTTCCTACCCTATTTTAGGAACAGTA
GAAACTGTAAAATCCTTTAAAAGAAAAGATATAGTAGATTACATAAATAAATATTATATTCCAGAAAATTCTGTTATATC
TATATGTGGTAATTTTGATATAAATGAATTAGAAAAATTAATAAATAAATATTTTGGTAATTGGAATAGCGGTGAAAATA
AAAACATAACTGTCTATTCCAAACCTAAAATAGAAAATAACCACTTATTTAAAAATAAAAATATAGAACAACTTCATATA
AGTTTAGGTTTTGAGGGATTAGAATTAGGGAATGATGATGCGTATCCTCTTATATTACTTAGTAATGTGTTGGGTGGAGG
AGCTTCATCTATACTATTTCAAAAGATAAGAGAAGAAAAAGGATTATGCTATAGTATATATTCTTATATGTCTTCCTTTA
ATAAAACAGGTGCGGTAAGCATTTATACAGGCTTAAATCCAGCCTATACAGAAGACACTATAACCTTAATAAAAAAGGTA
GTAAATGATTTTTCAAAGGAAGGTATAAATAAAGAAAAATTAATAAAATCAAAAGAACAATTAAAGGGAAGTTATATATT
AGGCTTAGAAAGCACTAGTACTAGAATGTTTAATAATGGCAAGTCTGTGCTATTTCTAAATAGAATAAATGATCCAGAAA
TAATAATGAAAAAAATAGATAAAATAACTGAAGATAAATTACAGGAAATAATGGATAAAACCTTTGGGGCTGGAATAAAA
AATTCAGCCTTTGTAGGAGAAAAATTAAATTTAGAGAATGTAAAAAATATTCTAGATAGAAACCAAAGAGCTTTCAAAGA
AACTAAATCAAAATTAATATAA

Upstream 100 bases:

>100_bases
ACAGAGTGCTGATTTGCTGATAATCGCTTTCATAGAGTGACATGGGAGTATTAGTAATGGTAACAATCGCAGAAATACGG
GGTTTAGGAGGAATTAATTA

Downstream 100 bases:

>100_bases
TATATTTTGTAATAAGCTCTCACTATTTTTCATAATATTGAATATGAATATTATGAGAAGTAATGGGAGGATTATTATGG
AAGAAAATATAAAACGCTAT

Product: peptidase, M16 family

Products: NA

Alternate protein names: ORFP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MYNLFTLDNGLRVVLENIDYVKSVSVGLWIENGSRNENLKNNGISHFIEHMMFKGTENRSALQIAECIEDVGGQINAFTG
KEATCYYIKILNSHIELALEVLSDMLFNSKFKEEDIEKEKGVIIEEISMTEDSPEDVLSDLHCKAIWGDDSISYPILGTV
ETVKSFKRKDIVDYINKYYIPENSVISICGNFDINELEKLINKYFGNWNSGENKNITVYSKPKIENNHLFKNKNIEQLHI
SLGFEGLELGNDDAYPLILLSNVLGGGASSILFQKIREEKGLCYSIYSYMSSFNKTGAVSIYTGLNPAYTEDTITLIKKV
VNDFSKEGINKEKLIKSKEQLKGSYILGLESTSTRMFNNGKSVLFLNRINDPEIIMKKIDKITEDKLQEIMDKTFGAGIK
NSAFVGEKLNLENVKNILDRNQRAFKETKSKLI

Sequences:

>Translated_433_residues
MYNLFTLDNGLRVVLENIDYVKSVSVGLWIENGSRNENLKNNGISHFIEHMMFKGTENRSALQIAECIEDVGGQINAFTG
KEATCYYIKILNSHIELALEVLSDMLFNSKFKEEDIEKEKGVIIEEISMTEDSPEDVLSDLHCKAIWGDDSISYPILGTV
ETVKSFKRKDIVDYINKYYIPENSVISICGNFDINELEKLINKYFGNWNSGENKNITVYSKPKIENNHLFKNKNIEQLHI
SLGFEGLELGNDDAYPLILLSNVLGGGASSILFQKIREEKGLCYSIYSYMSSFNKTGAVSIYTGLNPAYTEDTITLIKKV
VNDFSKEGINKEKLIKSKEQLKGSYILGLESTSTRMFNNGKSVLFLNRINDPEIIMKKIDKITEDKLQEIMDKTFGAGIK
NSAFVGEKLNLENVKNILDRNQRAFKETKSKLI
>Mature_433_residues
MYNLFTLDNGLRVVLENIDYVKSVSVGLWIENGSRNENLKNNGISHFIEHMMFKGTENRSALQIAECIEDVGGQINAFTG
KEATCYYIKILNSHIELALEVLSDMLFNSKFKEEDIEKEKGVIIEEISMTEDSPEDVLSDLHCKAIWGDDSISYPILGTV
ETVKSFKRKDIVDYINKYYIPENSVISICGNFDINELEKLINKYFGNWNSGENKNITVYSKPKIENNHLFKNKNIEQLHI
SLGFEGLELGNDDAYPLILLSNVLGGGASSILFQKIREEKGLCYSIYSYMSSFNKTGAVSIYTGLNPAYTEDTITLIKKV
VNDFSKEGINKEKLIKSKEQLKGSYILGLESTSTRMFNNGKSVLFLNRINDPEIIMKKIDKITEDKLQEIMDKTFGAGIK
NSAFVGEKLNLENVKNILDRNQRAFKETKSKLI

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=423, Percent_Identity=30.2600472813239, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI46593007, Length=399, Percent_Identity=26.5664160401003, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI24308013, Length=462, Percent_Identity=22.9437229437229, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI50592988, Length=410, Percent_Identity=19.7560975609756, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI155969707, Length=248, Percent_Identity=24.1935483870968, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787770, Length=244, Percent_Identity=25, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI2367164, Length=225, Percent_Identity=26.2222222222222, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=417, Percent_Identity=28.0575539568345, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17553678, Length=414, Percent_Identity=24.6376811594203, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17510601, Length=428, Percent_Identity=20.5607476635514, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323192, Length=438, Percent_Identity=28.5388127853881, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321813, Length=445, Percent_Identity=25.6179775280899, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319426, Length=273, Percent_Identity=24.1758241758242, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357875, Length=424, Percent_Identity=28.7735849056604, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646943, Length=424, Percent_Identity=28.7735849056604, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19921772, Length=446, Percent_Identity=23.542600896861, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24641429, Length=205, Percent_Identity=25.3658536585366, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49093; Mature: 49093

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNLFTLDNGLRVVLENIDYVKSVSVGLWIENGSRNENLKNNGISHFIEHMMFKGTENRS
CCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCH
ALQIAECIEDVGGQINAFTGKEATCYYIKILNSHIELALEVLSDMLFNSKFKEEDIEKEK
HHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GVIIEEISMTEDSPEDVLSDLHCKAIWGDDSISYPILGTVETVKSFKRKDIVDYINKYYI
CEEEEEECCCCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PENSVISICGNFDINELEKLINKYFGNWNSGENKNITVYSKPKIENNHLFKNKNIEQLHI
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEECCCCCEEEEE
SLGFEGLELGNDDAYPLILLSNVLGGGASSILFQKIREEKGLCYSIYSYMSSFNKTGAVS
EECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEE
IYTGLNPAYTEDTITLIKKVVNDFSKEGINKEKLIKSKEQLKGSYILGLESTSTRMFNNG
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHCCCC
KSVLFLNRINDPEIIMKKIDKITEDKLQEIMDKTFGAGIKNSAFVGEKLNLENVKNILDR
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
NQRAFKETKSKLI
HHHHHHHHHHCCC
>Mature Secondary Structure
MYNLFTLDNGLRVVLENIDYVKSVSVGLWIENGSRNENLKNNGISHFIEHMMFKGTENRS
CCEEEEECCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCH
ALQIAECIEDVGGQINAFTGKEATCYYIKILNSHIELALEVLSDMLFNSKFKEEDIEKEK
HHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHC
GVIIEEISMTEDSPEDVLSDLHCKAIWGDDSISYPILGTVETVKSFKRKDIVDYINKYYI
CEEEEEECCCCCCHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
PENSVISICGNFDINELEKLINKYFGNWNSGENKNITVYSKPKIENNHLFKNKNIEQLHI
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCEECCCCCEEEEE
SLGFEGLELGNDDAYPLILLSNVLGGGASSILFQKIREEKGLCYSIYSYMSSFNKTGAVS
EECCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEE
IYTGLNPAYTEDTITLIKKVVNDFSKEGINKEKLIKSKEQLKGSYILGLESTSTRMFNNG
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCHHHCCCC
KSVLFLNRINDPEIIMKKIDKITEDKLQEIMDKTFGAGIKNSAFVGEKLNLENVKNILDR
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
NQRAFKETKSKLI
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 8098035 [H]